TRANSLATIONAL GENOMICS SPEEDS CANCER RESEARCH USING ALTIX 4700.Discovering the differences and changes within the genome that trigger disease is a priority for The Translational Genomics Research Institute
The Translational Genomics Research Institute (TGen (TGen). To aid the non-profit research institute in their quest, TGen deployed technology from SGI (NASDAQ NASDAQ
in full National Association of Securities Dealers Automated Quotations
U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on :SGIC SGIC State Government Insurance Commission ) to more quickly analyze molecular profile data sets in their search for cancer cures. Purchased in April through a National Institute of Health (NIH "Not invented here." See digispeak.
NIH - The United States National Institutes of Health. ) grant, the SGI(R) Altix(R) 4700 will assist TGen researchers in understanding the genomic variation -- a process which requires comparison searches of enormous data sets -- that can be rapidly used for diagnosis and treatment of disease in a manner tailored to individual patients.
TGen selected the SGI Altix 4700 system with over half a terabyte of shared memory so researchers in the Phoenix, Ariz., institute can search across multiple chromosomes, all in memory, without having to break the problems into smaller pieces, enabling researchers to look at the whole instead of the sum of the parts.
While custom in-house code will be written for these large data searches, TGen reports that benchmarks were run on the National Center for Biotechnology Information The National Center for Biotechnology Information (NCBI) is part of the United States National Library of Medicine (NLM), a branch of the National Institutes of Health. The NCBI is located in Bethesda, Maryland and was founded in 1988. (NCBI NCBI National Center for Biotechnology Information (NIH)
NCBI National Coalition Building Institute
NCBI National Council for the Blind of Ireland (Dublin, Ireland) ) BLAST (Basic Local Alignment Search Tool), an algorithm for comparing primary biological sequence information, ClustalW, a general purpose multiple sequence alignment A multiple sequence alignment (MSA) is a sequence alignment of three or more biological sequences, generally protein, DNA, or RNA. In general, the input set of query sequences are assumed to have an evolutionary relationship by which they share a lineage and are descended from a program for DNA DNA: see nucleic acid.
or deoxyribonucleic acid
One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. or proteins, and NAMD NAMD National Association of Membership Development
NAMD National Association of Marble Dealers , a parallel molecular dynamics code for large biomolecular systems. Testing resulted in performance improvements of up to 50 percent on the 64-bit SGI Altix system as compared to their existing 32-bit system architecture.
"Technology, and microarrays specifically, have allowed the size of bioinformatics data sets to become so large that it became vital to acquire a large memory, 64-bit computational infrastructure to be able to manipulate and analyze those files at the level our researchers required," said James Lowey, Director of High Performance Bio-Computing, The Translational Genomics Research Institute. "Conventional 32-bit computer architectures cannot address memory above 4GB. This limitation poses sub-optimal analytical approaches due to the prohibitively protracted pro·tract
tr.v. pro·tract·ed, pro·tract·ing, pro·tracts
1. To draw out or lengthen in time; prolong: disputants who needlessly protracted the negotiations.
2. computer analysis time needed for optimal mathematical models and computational algorithms."
The molecular profile datasets being analyzed at TGen cover malignant myeloma, melanoma, Alzheimer's, autism and pancreatic, prostate, colon, and breast cancers. With microarrays, each individual file can be up to 150MB. To search and compare genetic patterns, researchers take hundreds and hundreds of copies of that individual file. TGen's code will harness the compute power of the SGI Altix system's global shared memory to run microarrays, searching for variations as minute as a change on one protein, trying to determine what effect that has across the entire spectrum of what is being observed.
"The success of TGen scientists to date has come at the sacrifice of time," said Dr. Edward Suh, CIO CIO: see American Federation of Labor and Congress of Industrial Organizations.
(Chief Information Officer) The executive officer in charge of information processing in an organization. of TGen. "However, individuals affected with the disease do not have the luxury of time. The 64-bit SGI computing system will optimize TGen researchers' ability to meet their data analysis needs efficiently, hopefully leading to timely and effective discovery for improved human health."
The system will be housed at Arizona State University Arizona State University, at Tempe; coeducational; opened 1886 as a normal school, became 1925 Tempe State Teachers College, renamed 1945 Arizona State College at Tempe. Its present name was adopted in 1958. (ASU) in Tempe, AZ, with operational support provided by ASU's Fulton High Performance Computing Initiative (HPCI HPCI High Pressure Coolant Injection (nuclear power)
HPCI Home Price Comparison Index
HPCI High Performance Computing Initiative
HPCI Harmonized Programmable Communications Interface ). "The shared memory capabilities of the new SGI system provide a welcome addition to the HPC portfolio in Arizona, and will enable researchers at TGen and their collaborators at ASU to address problems we've been unable to tackle in the past," said Dan Stanzione, the Director of the Fulton HPCI.
Purchased through James River Technical, Inc., SGI's designated partner for higher education and research, and installed in late May 2007, the SGI Altix 4700 system at TGen is equipped with 576GB memory and 48 Intel(R) Itanium(R) 2 cores.
"We are very excited about the award of the NIH grant to TGen, and the subsequent installation of the SGI Altix system", said Tom Mountcastle, president of James River Technical. "Genomics is a strategic focus for JRT and SGI and the management and processing of large data sets and workflow are ideal fits for the Altix 4700. We are pleased that the system has met the expectations of TGen and we are proud to be a part of the support infrastructure to facilitate this very important research that affects all of our lives."
"TGen's use of SGI technology is another example of SGI's ability to deliver solutions for demanding compute and data-intensive bioscience workflows," said Deepak Thakkar, biosciences segment manager for SGI. "The Altix system's scalability, flexibility and reliability, coupled with its interoperability, provide the best combination of compute, memory and I/O elements, matching the diverse needs of the TGen lab environment."
For more information, visit http://www.sgi.com or call 256/773-2371.