TRADE NEWS: Agilent Technologies Introduces HD-CGH Custom Microarrays for Pinpointing Cancer-Related Genetic Abnormalities.PALO ALTO Palo Alto, city, California Palo Alto (păl`ō ăl`tō), city (1990 pop. 55,900), Santa Clara co., W Calif.; inc. 1894. Although primarily residential, Palo Alto has aerospace, electronics, and advanced research industries. , Calif. -- Access to 4 Million Validated CGH CGH Comparative Genomic Hybridization CGH Changi General Hospital (Singapore) CGH Computer-Generated Hologram CGH Community General Hospital (Syracuse, NY) Probes Enables Customers to "Zoom In" on Chromosomal Changes With Unprecedented Precision, Resolution, Flexibility Agilent Technologies This article needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article. Inc. (NYSE NYSE See: New York Stock Exchange :A) today introduced an updated microarray-based Comparative Genomic Hybridization hybridization /hy·brid·iza·tion/ (hi?brid-i-za´shun) 1. crossbreeding; the act or process of producing hybrids. 2. molecular hybridization 3. (aCGH) platform featuring High-Definition CGH (HD-CGH) microarrays. Now researchers can easily design their own CGH microarrays to target specific "hot spots hot spots acute moist dermatitis. " in the genome. Platform enhancements also include reagents and analytics software updates. aCGH is one of the most promising methods for identifying and characterizing DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. copy number changes associated with cancer and genetic disorders. Agilent originally launched its breakthrough oligonucleotide (oligo) aCGH platform in January 2005, with a microarray for genome-wide scanning of chromosomal gains and losses on a single chip. The new, customizable HD-CGH microarrays now pinpoint these genomic aberrations. "As growing numbers of researchers recognize the power of array-based CGH analysis, Agilent is helping them leverage our expertise in probe design and selection," said Mike Booth, general manager of Agilent's Genomics Business. "Now researchers have the freedom and flexibility to design virtually any experiment using genome-wide or HD-CGH microarrays." Agilent's new HD-CGH custom microarrays and related probe design services allow researchers to draw upon Agilent's database of approximately 4 million pre-designed and computationally validated CGH probes and do high-resolution tiling of regions of interest at 10-100 times higher resolution. This enables customers to detect chromosomal changes that were difficult or impossible to detect using other platforms. In a related development, Agilent has also updated its Human Genome CGH Microarray with the addition of new probe set based on the latest genome build (NCBI NCBI National Center for Biotechnology Information (NIH) NCBI National Coalition Building Institute NCBI National Council for the Blind of Ireland (Dublin, Ireland) Build 35) to further expand the coverage. This microarray contains approximately 43,000 60-mer oligonucleotide probes, empirically validated in multiple model systems that span coding and non-coding sequences with an average spatial resolution (Data West Research Agency definition: see GIS glossary.) A measure of the accuracy or detail of a graphic display, expressed as dots per inch, pixels per line, lines per millimeter, etc. It is a measure of how fine an image is, usually expressed in dots per inch (dpi). of 35kb. Additional Platform Updates: Reagents and Software Agilent HD-CGH custom microarrays and off-the-shelf Human Genome CGH Microarray 44B are part of the enhanced oligo aCGH platform that also includes new reagents and updated CGH Analytics software. Agilent has optimized assay conditions to enable the use of full-complexity samples for reliable detection of DNA copy number changes. CGH Analytics software is the only commercial informatics system to visually explore and analyze aCGH data from single or multiple microarray experiments. The new version (v3.1) now offers improved aberration detection algorithms, analyzes data from replicate or dye-swap experiments, filters out unreliable or irrelevant data, compares results from multiple CGH array designs, and enables side by side visualization of Agilent gene expression and CGH data. More information about Agilent's oligo aCGH platform is available at www.agilent.com/chem/goCGH. About Agilent Technologies Agilent Technologies Inc. (NYSE:A) is the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The company's 28,000 employees serve customers in more than 110 countries. Agilent had net revenue of $7.2 billion in fiscal year 2004. Information about Agilent is available on the Web at www.agilent.com. NOTE TO EDITORS: Press releases, photography and other information can be accessed on the Agilent Life Sciences and Chemical Analysis newsroom at www.agilent.com/about/newsroom/lsca. Further technology, corporate citizenship Corporate Citizenship The extent to which businesses are socially responsible in meeting legal, ethical and economic responsibilities placed on them by shareholders. The aim it to create higher standards of living and quality of life in the community in which it operates, while and executive news is available on the Agilent news site at www.agilent.com/go/news. |
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