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TPG Biotech to Fund Development of JCR Pharmaceuticals Drug Candidates.

TOKYO -- TPG TPG Texas Pacific Group
TPG Tapping
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TPG Test Pattern Generator
TPG TNT Post Group
TPG Trésorier Payeur Général
 Biotech and JCR JCR Journal Citation Reports
JCR Java Content Repository (IBM)
JCR Junior Common Room (British university term)
JCR Journal of Clinical Rheumatology
JCR Journal of Circadian Rhythms
 Pharmaceuticals Co., Ltd. of Ashiya, Japan jointly announced that they have entered into an Investment Agreement to fund the late-stage clinical development of two promising drug candidates for JCR, JR-013 and Growject[R]. Terms of the agreement were not disclosed.

JR-013 is a recombinant human erythropoietin for the treatment of renal anemia in dialysis patients. The drug was originated by JCR and is currently undergoing Phase II/III clinical studies in Japan. JR-013 is manufactured using JCR's proprietary technology which is highly efficient and is safe from animal-source pathogens such as BSE See Bombay Stock Exchange.


See Boston Stock Exchange (BSE).
 (Bovine Spongiform Encephalopathy bovine spongiform encephalopathy: see prion. , or "mad cow disease mad cow disease: see prion.
mad cow disease
 or bovine spongiform encephalopathy (BSE)

Fatal neurodegenerative disease of cattle. Symptoms include behavioral changes (e.g.

Growject[R] is currently approved and marketed in Japan to treat short stature in children with growth hormone deficiency growth hormone deficiency Hypopituitarism Endocrinology A condition which affects 1:4000 children; ♂:♀, 3-4:1 Etiology 70% of GHD is idiopathic and attributed to a prenatal insult, possibly due to hypothalamic dysfunction, given that GHD children  and Turner's Syndrome. JCR is extending Growject[R] use to treat Adult Growth Hormone Deficiency (AGHD AGHD Adult Growth Hormone Deficiency ). Clinical studies for AGHD have been completed and application for an approval of such extended use has been filed with the Japanese Ministry of Health, Labor and Welfare.

Under the terms of the Investment Agreement, TPG Biotech will fund the development of the drugs, and in return will receive milestone payments, royalties and warrants to purchase JCR's common stock.

"We are pleased that the consummation of this Agreement shows how highly TPG Biotech values JCR's pharmaceutical products under development and manufacturing technology. We welcome the investment by TPG Biotech. Their support will allow us to produce these needed drugs quickly and efficiently and bring them to market," said Mr. Shin Ashida, Chairman and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of JCR.

Geoffrey Duyk, MD, PhD, a partner at TPG Biotech, said, "We are intrigued by JCR's proprietary manufacturing technology that allows efficient production of therapeutic proteins while avoiding any risk of BSE. We anticipate that these products will become successful in Japan and then prove viable in additional markets worldwide."

"We are impressed with JCR's manufacturing quality as well as the strength and depth of its management team," added Eran Nadav, PhD, a member of the TPG Biotech team.

About JCR Pharmaceuticals

JCR Pharmaceuticals Co., Ltd. is a fully integrated company engaged in the research, development, manufacture and sale of pharmaceutical products. Under JCR's corporate philosophy of "contributing to people's healthcare through pharmaceutical products," the company has developed recombinant proteins and cell culturing technologies. The company is headquartered in Ashiya, Japan, and has 214 employees.

About TPG Biotechnology

TPG Biotech is part of the venture capital investment platform of TPG, the global private investment firm. With more than $500 million under management, TPG Biotech targets investments in life science, biotechnology, renewables and medical technology companies. The firm is backed by the resources of TPG, with more than $35 billion of assets under management Assets Under Management (AUM) is a term used by financial services companies in the mutual fund and money management or investment management business to gauge how much money they are managing. .

About TPG

TPG is one of the world's leading private investment firms with a history of investments in the healthcare field (Axcan Pharma, Biomet, Fenwal, Iasis, Parkway, Quintiles Quintiles Transnational Corp. is a contract research organization which serves the pharmaceutical, biotechnology and healthcare industries. History
Quintiles was founded in 1982 by Dennis Gillings and as of 2007 it has 18,000 employees.
 Transnational) and in global companies across a range of industries (Bally, Burger King, Ducati Motorcycles, Lenovo, Metro Goldwyn Mayer (MGM) and Neiman Marcus). In Japan, TPG is expanding its footprint after purchasing stakes in toy maker TOMY in March 2007 and the financial firm NIS Group in February 2008. Please visit
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Publication:Business Wire
Article Type:Clinical report
Date:Mar 12, 2008
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