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Symptom combination points to endometriosis: pelvic pain and dysmenorrhea 'are actually more specific than previously acknowledged.'.



WASHINGTON -- The constellation of symptoms characterizing endometriosis may be more specific than currently thought, Karen D. Ballard, Ph.D., said at the annual meeting of the AAGL.

There is often a long delay in the diagnosis of endometriosis, in large part because the symptoms--primarily pelvic pain and dysmenorrhea--are nonspecific and can overlap with other conditions. But now, a case-control study from a primary care database in the United Kingdom suggests that women with a combination of gynecologic gynecologic /gy·ne·co·log·ic/ (gi?ne-) (jin?e-kah-loj´ik) pertaining to the female reproductive tract or to gynecology. , urologic, and bowel symptoms are likely to have the condition.

"Specific, unremitting symptoms should raise a high suspicion of endometriosis," said Dr. Ballard of the University of Surrey The University of Surrey is a public university in Guildford, England. It received its charter on 9 September 1966, and was situated near Battersea Park in south-west London. The institution was known as Battersea College of Technology before gaining university status. , Guildford, England.

Data were collected from the General Practice Research Database, the largest computerized database in the world containing longitudinal medical records from primary care. The database currently comprises more than 3 million active patients from about 450 primary care practices, the setting in which all nonemergency patients in the United Kingdom are first seen.

During 1992-2002, 5,540 cases of endometriosis were identified from a total of 1,276,100 women aged 15-55 years. The average age at diagnosis was 35 years. The incidence of diagnosed endometriosis was 0.97 per 1,000 woman-years, and the prevalence--calculated from the incidence rate and the average disease duration--was 1.5%.

This proportion is lower than what has been reported in the literature, probably because it comes from general medical practice rather than a gynecology-based setting, Dr. Ballard noted.

There were 21,239 matched controls. The women with endometriosis were significantly thinner, with 49.3% having a body mass index less than 25 kg/[m.sup.2], compared with 42.1% of the controls. They were also 20% less likely than were the controls to have had a previous pregnancy.

As expected, the women with endometriosis had high rates of pelvic pain (15.6%) and dysmenorrhea (24.6%). But somewhat surprising was how low those rates were in the controls--1.5% and 3.4%, respectively--suggesting that "these symptoms are actually more specific than previously acknowledged," Dr. Ballard said.

Other menstrual/pain symptoms reported significantly more often by the endometriosis patients than the controls were dyspareunia dyspareunia /dys·pa·reu·nia/ (-pah-roo´ne-ah) difficult or painful sexual intercourse.

dys·pa·reu·ni·a
n.
Difficult or painful sexual intercourse.
 (9% vs. 1%, respectively), abdominal pain (45% vs. 13%), menorrhagia menorrhagia /men·or·rha·gia/ (men?ah-ra´jah) hypermenorrhea.

men·or·rha·gia
n.
See hypermenorrhea.
 (23% vs. 6%), and menstrual problems (27% vs. 13%).

Gastrointestinal symptoms were also more common in the endometriosis group than in the control group, including constipation (9.2% vs. 4.4%) and rectal bleeding (2.0% vs. 1.1%), as were the urologic symptoms cystitis (8.8% vs. 5.3%) and dysuria dysuria /dys·uria/ (dis-u´re-ah) painful or difficult urination.dysu´ric

dys·u·ri·a
n.
Difficult or painful urination.
 (6.1% vs. 2.7%).

Postcoital bleeding was reported by 2.9% vs. 0.7% and backache by 16.4% vs. 11.0%. All of these differences were statistically significant.

Women with endometriosis were also significantly more likely than were controls to have been diagnosed with sub-fertility (9.6% vs. 1.8%). But less expected was an association with the diagnosis of irritable bowel syndrome irritable bowel syndrome (IBS), condition characterized by frequently alternating constipation and diarrhea in the absence of any disease process. It is usually accompanied by abdominal pain, especially in the lower left quadrant, bloating, and flatulence. : 10.6% vs. 3.3%.

Other diagnoses reported significantly more often among the women with endometriosis were urinary tract infection urinary tract infection (UTI),
n infection in one or more of the structures that make up the urinary system. Occurs more often in women and is most commonly caused by bacteria.
 (18.5% vs. 9.8%), pelvic inflammatory disease pelvic inflammatory disease (PID), infection of the female reproductive organs, usually resulting from infection with the bacteria that cause chlamydia or gonorrhea.  (10.3% vs. 1.8%), and ovarian cysts (6.8% vs. 0.6%).

Stepwise regression analysis showed that the five "key symptoms" most strongly associated with endometriosis were infertility or subfertility (adjusted odds ratio 8.2), dysmenorrhea (8.1), symptoms associated with sexual intercourse (6.8), abdominopelvic pain (5.2), and menorrhagia (4.0).

In all, 84% of those with endometriosis had at least one of those symptoms, compared with 23% of those without, Dr. Ballard said.

The data also suggest there is opportunity for intervention: Nearly all (98%) of the women who were ultimately diagnosed with endometriosis had made at least one visit to a physician in the year before the diagnosis, compared with 81% of the controls.

In fact, 62% had visited the physician at least six times in that year, compared with 27% of those not diagnosed with endometriosis, she reported.

BY MIRIAM E. TUCKER

Senior Writer
Adjusted Odds Ratios for Five 'Key Symptoms' of Endometriosis

Infertility or subfertility                  8.2
Dysmenorrhea                                 8.1
Symptoms associated with sexual intercourse  6.8
Abdominopelvic pain                          5.2
Menorrhagia                                  4.0

Note: Based on a study of 5,540 women with endometriosis, compared with
21,239 controls.
Source: Dr. Ballard
ELSEVIER GLOBAL MEDICAL NEWS

Note: Table made from bar graph.
COPYRIGHT 2008 International Medical News Group
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Title Annotation:Women's Health
Author:Tucker, Miriam E.
Publication:Internal Medicine News
Article Type:Clinical report
Geographic Code:1USA
Date:Jan 15, 2008
Words:723
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