Sustiva: revised drug-interaction information.On January 31 the FDA announced that the Sustiva (efavirenz) package insert had been changed "to include drug-drug interaction information regarding coadministration of efavirenz with rifampin, diltiazem, itraconazole itraconazole /it·ra·co·na·zole/ (it?rah-kon´ah-zol) a triazoleantifungal used in a variety of infections. it·ra·con·a·zole n. , voriconazole, atorvastatin atorvastatin /ator·va·stat·in/ (ah-tor?vah-stat´in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the calcium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia. , pravastatin pravastatin /prav·a·stat·in/ (prav´ah-stat?in) an antihyperlipidemic agent that acts by inhibiting cholesterol synthesis, used as the sodium salt in the treatment of hypercholesterolemia and other forms of dyslipidemia and to lower the , simvastatin, pimozide pimozide /pi·mo·zide/ an antipsychotic and antidyskinetic agent used in the treatment of Gilles de la Tourette's syndrome. pim·o·zide n. and bepridil." The complete list of changes is at http://www.fda.gov/oashi/aids/listserve/listserve2007.html#13107 And the complete, revised prescribing information for physicians (and other information for patients) is at http://www.sustiva.com. (Click "Full U.S. Prescribing Information" to download a PDF file--and change the ending of the file name from .pl to .pdf is necessary.) |
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