COOK[R] has developed Surgisis[TM] soft-tissue graft for implantation, to reinforce soft tissue where weakness exists. This product is made from small intestinal submucosa Small intestinal submucosa (SIS) is a common, non-immunogenic material used in several clinical applications. Some uses under investigation include a scaffold for intervertebral disc regeneration. (SIS), a naturally occurring extracellular matrix extracellular matrix (eksˈ·tr·selˑ·y . After being surgically implanted, Surgisis is designed to support damaged tissue while its fibrous fibrous /fi·brous/ (fi´brus) composed of or containing fibers.
Composed of or characterized by fibroblasts, fibrils, or connective tissue fibers. , three-dimensional matrix is gradually replaced by the body's own tissue.
Surgisis sheets are available in several strengths to meet surgical requirements and can be cut, rolled, or folded. Although thin, pliable, and easy to handle, Surgisis is strong enough to hold sutures or staples. It comes in sterile, peel-open packages, has an extended shelf life, and requires no refrigeration refrigeration, process for drawing heat from substances to lower their temperature, often for purposes of preservation. Refrigeration in its modern, portable form also depends on insulating materials that are thin yet effective. .