Printer Friendly

Success on the vaccine front.

Vaccination with either of two specific proteins isolated from Borrelia burgdorferi, the bacterium that causes Lyme disease, can protect mice from the infection, researchers from Yale University have found. The vaccines can also prevent ticks from spreading the disease, they report.

The investigators, led by Erol Fikrig, injected mice with either OspA or OspB, two proteins from the outer wall of B. burgdorferi. When they allowed young deer ticks infected with the bacteria to feed on the mice, they discovered that the mice remained uninfected. Moreover, studies revealed that ingested blood from the mice killed all of the B. burgdorferi in the guts of the ticks, halting the dissemination of the disease.

Fikrig and his colleagues conclude that either protein might constitute an effective vaccine against Lyme disease. "They're both effective in our initial experiments," he says. But he cautions that the proteins vary among different strains of B. burgdorferi, so the best vaccine might consist of a combination of various OspA or OspB proteins.

Fikrig says his group hopes to begin clinical trials of a Lyme vaccine within the next three years. They also plan to test whether baits soaked with an oral form of the vaccine might reduce the number of infected mice in the wild.
COPYRIGHT 1992 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 1992, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:protein vaccine for prevention of Lyme disease
Author:Ezzell, Carol
Publication:Science News
Article Type:Brief Article
Date:Jun 13, 1992
Words:208
Previous Article:Same disease, different transmission.
Next Article:Clue to cigarettes' role in emphysema.
Topics:


Related Articles
Will there be an AIDS vaccine? Research is speeding ahead, but there are many scientific roadblocks in the way of developing a safe and effective...
Bio-tick-nology yields Lyme disease vaccine.
Clinical trials begin for Lyme disease vaccine.
Therapeutic vaccine fights herpes.
Nose-drop vaccine provides protection.
Lyme vaccine proves highly effective.
The cost-effectiveness of vaccinating against Lyme disease.
The Cost Effectiveness of Vaccinating against Lyme Disease.
Biomedicine: Lyme vaccine works in a curious way.
Running into Lyme disease.

Terms of use | Copyright © 2016 Farlex, Inc. | Feedback | For webmasters