Structural Bioinformatics Inc. Initiates Drug Discovery Partnership With Japanese Firm.SAN DIEGO--(BW HealthWire)--Oct. 15, 1997--Privately held Structural Bioinformatics Structural bioinformatics refers to the branch of bioinformatics which is related to the analysis and prediction of the three-dimensional structure of biological macromolecules such as proteins. Inc. (SBI SBI Special Background Investigation SBI Subsidiary Body for Implementation SBI State Bank of India SBI Secure Border Initiative SBI Small Business Institute SBI Stockholm Brain Institute SBI Serious Bacterial Infection SBI Society of Breast Imaging ) of San Diego San Diego (săn dēā`gō), city (1990 pop. 1,110,549), seat of San Diego co., S Calif., on San Diego Bay; inc. 1850. San Diego includes the unincorporated communities of La Jolla and Spring Valley. Coronado is across the bay. , Wednesday announced an agreement with a major Japanese pharmaceutical company to design novel compounds based on SBI's proprietary Dynapharm technology. "SBI has extended its reach into Asia Pacific with this collaboration," said Edward T. Maggio, president and chief executive officer of SBI. "The strategic fit with our new partner is particularly good, and the project is an important application of our ability to do virtual chemical screening with SBI's dynamically modeled templates of protein active sites." In this collaboration, SBI will computationally screen and identify low molecular weight compounds that interact with a certain target receptor protein receptor protein n. An intracellular protein or protein fraction having a high specific affinity for binding agents known to stimulate cellular activity, such as a steroid hormone or cyclic AMP. , and the Japanese company will test the activities of the identified compounds. Based on the data obtained, the two companies will further screen and/or synthesize compounds with higher activities, and hope to find an attractive drug lead in a relatively short timeframe. This is SBI's second corporate alliance. In addition to this Japanese company, which has requested that its name not be disclosed at this time, SBI also recently announced a lead-finding deal with BioChem Pharma Ltd. (Canada), and pursues in-house lead discovery and development in the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. . Structural Bioinformatics has developed a supercomputational operating system operating system (OS) Software that controls the operation of a computer, directs the input and output of data, keeps track of files, and controls the processing of computer programs. making possible the immediate and practical use of genomic (gene sequence) data in a broad range of structure-based drug discovery and design processes leading to the rapid design and identification of small molecule lead compounds. SBI is building corporate partnerships with pharmaceutical companies, gene discovery companies, and combinatorial chemistry Combinatorial chemistry involves the rapid synthesis or the computer simulation of a large number of different but structurally related molecules. Introduction Synthesis of molecules in a combinatorial fashion can quickly lead to large numbers of molecules. companies ranging from broad technology collaborations to assistance with specific drug targets or target groups. CONTACT: Structural Bioinformatics Inc. Susan Burgess, 619/675-2400 http://www.strubix.com |
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