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Statins could help prevent prostate cancer, other related diseases.

Byline: ANI

Washington, Apr 27 (ANI): Statins Statins
A class of drugs commonly used to lower LDL cholesterol levels.

Mentioned in: C-Reactive Protein
, drugs widely prescribed to lower cholesterol, could protect against prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men.  and other related diseases, according to according to
1. As stated or indicated by; on the authority of: according to historians.

2. In keeping with: according to instructions.

 a new study.

In the large Mayo Clinic Mayo Clinic: see Mayo, Charles Horace.

Mayo Clinic

voluntary association of more than 500 physicians in Rochester, Minnesota. [Am. Hist.: EB, 11: 723]

See : Medicine
 cohort study, researchers looked at three different aspects of urological health-prostate cancer, erectile dysfunction Erectile Dysfunction Definition

Erectile dysfunction (ED), formerly known as impotence, is the inability to achieve or maintain an erection long enough to engage in sexual intercourse.
 and prostate enlargement.

The findings of the study came from data in the Olmsted County Study of Urinary Health Status among Men, a large cohort study of men living in Olmsted County, Minn, which followed 2,447 men ages 40 to 79 from 1990 to the present to assess various urologic outcomes among aging men.

"One of the major advantages of this large cohort study is that the men have participated in this study for over 15 years. Because of this, we have the ability to look at associations between statin stat·in
Any of a class of drugs that inhibit a key enzyme involved in the synthesis of cholesterol and promote receptor binding of LDL cholesterol, resulting in decreased levels of serum cholesterol.
 use, how long statins were used and multiple aspects of urologic function," said Jennifer St. Sauver, Ph.D., Mayo Clinic epidemiologist and study author.

In the first study, researchers followed the 2,447 men for over 15 years and discovered that men taking statins were less likely to develop prostate cancer, as compared to men who did not take statins.

Out of all the statin users, 38 (6 percent) were diagnosed with prostate cancer, while, non-statin users were three times more likely to develop prostate cancer, suggesting statin use may prevent development of prostate cancer.

Currently, statin medications are used to lower cholesterol or to help prevent heart attack and stroke in high-risk patients.

In the laboratory setting, researchers have observed that statin medications prevent cancer cells from dividing and, may even cause some cancer cells to die.

Although the results are preliminary, researchers claimed that randomized controlled trials are necessary to determine if statins are protective for prostate cancer.

It is known that hyperlipidemia hyperlipidemia /hy·per·lip·id·emia/ (-lip?i-de´me-ah) elevated concentrations of any or all of the lipids in the plasma, including hypertriglyceridemia, hypercholesterolemia, etc. , high cholesterol Cholesterol, High Definition

Cholesterol is a fatty substance found in animal tissue and is an important component to the human body. It is manufactured in the liver and carried throughout the body in the bloodstream.
 and other risk factors for heart disease, could put men at risk for erectile dysfunction (ED).

Thus, in the second study the researchers examined 1,480 men from the Olmsted County cohort to determine if men who used statins were less likely to develop erectile dysfunction, compared to men who did not use statins.

It was found that overall, statin use was not significantly associated with a decreased risk of developing ED.

However, statins were associated with a decreased risk of ED among older men (>60 years).

Men in this age group who used statins were less likely to develop ED, compared to older men who did not use statins.

Additionally, men who took statins for a longer time were more protected against developing ED.

Usually, benign prostatic enlargement is diagnosed when men visit their physicians due to urinary problems prompted by prostate enlargement.

Researchers have now found that taking statins may prevent or delay benign prostatic enlargement.

Of the 2,447 men studied, 729 (30 percent) were statin users-researchers found that statin users were 63 percent less likely to develop lower urinary tract problems and 57 percent less likely to develop an enlarged prostate Enlarged Prostate Definition

A non-cancerous condition that affects many men past 50 years of age, enlarged prostate makes urinating more difficult by narrowing the urethra, a tube running from the bladder through the prostate gland.

"Statins have been shown to have anti-inflammatory effects, and previous research suggests inflammation may be associated with benign prostate disease. This study suggests that men's urinary health could be improved by taking statin medications," said St. Sauver. "."

According to the researchers, further studies, particularly clinical trials, are necessary to determine whether taking statins might prevent development of this common condition.

"If you are taking a statin for a heart condition or to lower cholesterol, these studies suggest that statins could have other benefits. However, it's very clear we need more information before men are advised to start taking statins for their urological health," said St. Sauver.

The study results were presented at the American Urological Association (AUA AUA American Urological Association, see there ) meeting in Chicago. (ANI)

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Publication:Asian News International
Date:Apr 27, 2009
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