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Spontaneous coronary artery dissection: a long-term follow-up / Spontan koroner arter disseksiyonu: uzun donem takibi.



Introduction

Spontaneous coronary artery dissection (SCAD scad

transitory lameness in sheep, reputed to follow frosty conditions and to be a dermatitis caused by cold injury.
) is a rare cause of acute coronary syndrome acute coronary syndrome
n.
A sudden, severe coronary event that mimics a heart attack, such as unstable angina.


acute coronary syndrome 
 with a high risk of mortality (1). Clinical presentation may vary from mild symptoms to sudden cardiac death Sudden Cardiac Death Definition

Sudden cardiac death (SCD) is an unexpected death due to heart problems, which occurs within one hour from the start of any cardiac-related symptoms. SCD is sometimes called cardiac arrest.
. It is more common in women and involves coronary arteries that differ based on gender (2). Although many factors are thought to be known, its etiology is still unclear. In this case report, a patient with SCAD who remained stable during a 34-month follow-up without any intervention is presented.

Case report

A 50-year-old man was presented to emergency department with a feeling of a retrosternal pressure at rest. Pain was recurrent without radiation to the neck and arms. There was no triggered physical or emotional stress. Electrocardiography electrocardiography (ĭlĕk'trōkärdēŏg`rəfē), science of recording and interpreting the electrical activity that precedes and is a measure of the action of heart muscles.  (ECG) showed negative T waves in leads V5-V6, DII-DIII-aVF (Fig. 1).

Patient's past medical history showed that there was no previous coronary artery disease coronary artery disease, condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue. . Assessment of coronary heart disease coronary heart disease: see coronary artery disease.
coronary heart disease
 or ischemic heart disease

Progressive reduction of blood supply to the heart muscle due to narrowing or blocking of a coronary artery (see atherosclerosis).
 risk factors revealed that the patient had no hypertension, diabetes, family history of premature coronary artery disease (CAD) and smoking. Lipid profile was normal except a low level of high-density lipoprotein-cholesterol (HDL-C HDL-C high-density-lipoprotein cholesterol. ). Non-traditional risk factors such as homocysteine, lipoprotein (a), high sensitive-C reactive protein (hs-CRP), were also within normal limits. There were no symptoms or signs suggesting any inflammatory or infectious diseases.

At presentation his blood pressure was 100/65 mmHg, pulse was 78 beats/minute and he was in a sinus rhythm. The clinical examination was unremarkable. During the follow-up creatine kinase-MB increased to 62 U/L and cardiac troponin I increased to 0.97 ng/ml (upper normal limit 20 U/L; 0.04 ng/ml respectively). The patient was given metoprolol metoprolol /met·o·pro·lol/ (met?ah-pro´lol) a cardioselective ß used in the form of the succinate and tartrate salts in the treatment of hypertension, chronic angina pectoris, and myocardial infarction.  100 mg once a day, enoxaparine 80 mg twice a day subcutaneously, nitroglycerine IV infusion once in every 18 hours, acetyl salicylic acid 300 mg once in a day and finally clopidogrel 75 mg once in day. Three hours after the initiation of the therapy, the patient was free of chest pain.

Coronary angiography on the 4th day of hospital stay revealed that a type D spontaneous dissection (Video 1. See corresponding video/movie images at www.anakarder.com) (3) extending from the mid portion to distal of the left circumflex circumflex /cir·cum·flex/ (serk´um-fleks) curved like a bow.

cir·cum·flex
adj.
1. Curving or bending around.

2. Bowed.



circumflex

curved like a bow.
 artery's (Cx) first obtuse margin branch with TIMI-III flow beyond the dissection (Fig. 2A). A mild vasospasm vasospasm /vaso·spasm/ (va´zo-) (vas´o-spazm) angiospasm; spasm of blood vessels, causing vasoconstriction.vasospas´tic

va·so·spasm
n.
 was observed proximal to the obtuse marginal artery but there was no atherosclerotic plaque in the entire coronary bed. Percutaneous coronary intervention Percutaneous coronary intervention (PCI), commonly known as coronary angioplasty or simply angioplasty, is a therapeutic procedure to treat the stenotic (narrowed) coronary arteries of the heart found in coronary heart disease.  (PCI) was not planned due to long segment dissection and absence of recurrent chest pain. Patient was discharged on the 6th day with the same doses of metoprolol, acetyl salicylic acid, and clopidogrel. Additionally 60 mg isosorbid-5-mononitrate was started. Patient was asked to be controlled with coronary angiography three months after the hospital discharge.

One month after the discharge, myocardial myocardial /myo·car·di·al/ (-kahr´de-al) pertaining to the muscular tissue of the heart.

myocardial

pertaining to the muscular tissue of the heart (the myocardium).
 perfusion scintigraphy scintigraphy /scin·tig·ra·phy/ (sin-tig´rah-fe) the production of two-dimensional images of the distribution of radioactivity in tissues after the internal administration of a radiopharmaceutical imaging agent, the images being obtained  yielded that inferolateral ischemia without any fixed perfusion defect was present. Moreover, control coronary angiography (Video 2. See corresponding video/movie images at www.anakarder.com) showed that neither spontaneous recovery nor progression of the dissection existed (Fig. 2B). By contrast, proximal segment of the obtuse marginal artery was in normal size compared to that of the first angiography. As a result, according to absence of angina and extension of ischemic Ischemic
An inadequate supply of blood to a part of the body, caused by partial or total blockage of an artery.

Mentioned in: Antiangiogenic Therapy, Subarachnoid Hemorrhage, Ventricular Fibrillation


ischemic
 area beyond circumflex territory, PCI was not planned due to long segment dissection of a small size side branch.

He is still on follow-up for 34 months. Despite the persistent myocardial ischemia in inferolateral region, he has not experienced any major cardiac event or angina both at exercise and at rest.

[FIGURE 1 OMITTED]

Discussion

Spontaneous coronary artery dissection was first described by Pretty in 1931 in an autopsy study of a 42-year old woman with sudden cardiac death (4). It is a very rare cause of acute coronary syndromes. Its presentation spectrum could vary from mild exercise angina to serious myocardial infarction, cardiogenic shock or even sudden cardiac death. Nearly 70% of the SCAD cases are diagnosed in post-mortem studies caused by sudden cardiac death (2).

Spontaneous coronary artery dissection is more common in women than in men (3:1). Approximately 25% of the cases seen were middle-aged women during pregnancy or in the puerperium puerperium /pu·er·pe·ri·um/ (pu?er-per´e-um) the period or state of confinement after childbirth.

pu·er·pe·ri·um
n. pl. pu·er·pe·ri·a
1.
 period. In addition, oral contraceptive use, i.e., progesterone in particular, is thought to have a role in the etiology (1, 2).

Involved coronary arteries differ according to the gender. While left anterior descending (LAD) artery and Cx artery are more commonly involved (87%) in women; right coronary artery (RCA) is the most commonly involved (67%) in men (2). However, independent from the gender, overall LAD is affected in 75% of cases and RCA is affected only in 20% of cases. Also, left Cx is affected in about 4% of cases and the rate for LMCA involvement is less than 1% of cases (5).

Although, SCAD is more commonly occurred during pregnancy, various other factors are also found to play a role in its etiology. There is a special class of SCAD, which develops on a preexisting pre·ex·ist or pre-ex·ist  
v. pre·ex·ist·ed, pre·ex·ist·ing, pre·ex·ists

v.tr.
To exist before (something); precede: Dinosaurs preexisted humans.

v.intr.
 atheromatous ath·er·o·ma  
n. pl. ath·er·o·mas or ath·er·o·ma·ta
A deposit or degenerative accumulation of lipid-containing plaques on the innermost layer of the wall of an artery.
 plaque (6). Studies with intracoronary ultrasound (IVUS IVUS Intravascular ultrasound, see there ) have shown that the rupture of the plaque starts bleeding between media and intima intima /in·ti·ma/ (in´ti-mah)
1. innermost.

2. tunica intima vasorum.in´timal


in·ti·ma
n. pl.
 leading to the separation of these layers and eventually causing the dissection (7). However, it has been postulated that atheromatous origin of the SCAD has a better prognosis than other origins of SCAD due to well developed collaterals in these patients (6-7).

In this case, plain coronary angiography did not reveal any atherosclerotic plaque in the entire coronary artery; however, confirmation with IVUS was necessary to rule out atherosclerotic etiology (7). In order to conclude that there was no atherosclerotic plaque in certainty, IVUS should have been used. Unfortunately, at the time when the angiography was performed, IVUS was not available. Therefore, it was not used. On the other hand, despite the unavailability of IVUS, lacking of either traditional or non-traditional risk factors for atherosclerotic disease supports that it could have non-atherosclerotic origin. Again, it is important to note that lacking of traditional or non-traditional factors does not necessarily rule out or exclude other possible sources.

[FIGURE 2 OMITTED]

Treatment options for SCAD vary from medical treatment to different coronary revascularization methods. Due to its rare occurrence, there are no studies comparing the effectiveness of the different treatment approaches.

In some cases who presented with ST segment elevation acute myocardial infarction acute myocardial infarction (·kyōōtˑ mī·ō·karˑ·dē· , thrombolytic treatment was used. It is believed that the fibrinolysis fibrinolysis /fi·bri·nol·y·sis/ (fi?brin-ol´i-sis) dissolution of fibrin by enzymatic action.fibrinolyt´ic

fi·bri·nol·y·sis
n. pl.
 of the blood clot formed in the false lumen is beneficial (8). However, due to the potential risk of worsening of the dissection by increasing the hemorrhage, fibrinolysis is usually not recommended if dissection was diagnosed visually. Vasodilating drugs including nitrates, calcium channel blockers Calcium Channel Blockers Definition

Calcium channel blockers are medicines that slow the movement of calcium into the cells of the heart and blood vessels.
 are suggested to be used to decrease the vasospasm and prevent the further extension of the dissection (2).

Percutaneous transcatheter stent implantation is preferred in patients with a single vessel disease single vessel disease Univessel disease Cardiology  Coronary atherosclerosis that is very advanced in one artery , which is not involving the LMCA, especially in localized and not extended dissections (9). Usually multiple overlapping stents are required to cover the dissected area.

Even though coronary bypass surgery Coronary bypass surgery
A surgical procedure which places a shunt to allow blood to travel from the aorta to a branch of the coronary artery at a point past an obstruction.

Mentioned in: Cardiac Catheterization, Thallium Heart Scan
 is the therapeutic intervention of choice in dissections, its use is limited because usually the dissection extends further than that is shown on the angiogram an·gi·o·gram
n.
An angiographic x-ray of blood vessels used in diagnosing pathological conditions of the cardiovascular system.//An x-ray of one or more blood vessels produced by angiography and used in diagnosing pathology in the cardiovascular
, making it difficult to place the graft in the dissected area. Therefore, DeMaio et al (10) suggested using coronary bypass operation only in cases with left main involvement, three-vessel dissections or presence of recurrent ischemia.

In this case, thrombolytic therapy was not considered due to absence of acute ST- segment-elevation myocardial infarction at the time of admission. Coronary bypass operation was also not considered due to absence of left main coronary artery or multiple vessel dissections. As being the most beneficial therapeutic option, especially in one-vessel dissections, percutaneous coronary stent implantation was not considered for this case despite presence of ischemia limited to dissection area in myocardial perfusion scintigraphy. Stent implantation was not thought to be appropriate because of long segment dissection of a small size (<2mm) side branch coronary artery dissection, which would require multiple overlapping stent implantations. In addition, absence of angina and lacking of ischemic area extension encouraged to do continuing follow-ups under medical therapy.

Conclusion

Spontaneous coronary dissection should be kept in mind as one of the possible causes of acute coronary syndromes even though it rarely exists. Although there is no definitive guideline for optimal treatment of SCAD, from the experiences of reported series in the literature, it is suggested that medical treatment with close follow-ups for stable patients with a preserved good left ventricular function could be beneficial.

References

(1.) Basso C, Morgagni GL, Thiene G. Spontaneous coronary artery dissection: a neglected cause of acute myocardial ischaemia and sudden death. Heart 1996; 75: 451-4.

(2.) Hamilos MI, Kochiadakis GE, Skalidis EI, Igoumenidis NE, Chrysostomakis SI, Vardakis KE, et al. Acute myocardial infarction in a patient with spontaneous coronary artery dissection. Hellenic J Cardiol 2003; 44: 348-51.

(3.) Dorros G, Cowley MJ, Simpson J, Bentivoglio LG, Block PC, Bourassa M, et al. Percutaneous transluminal coronary angioplasty percutaneous transluminal coronary angioplasty
n. Abbr. PTCA
A procedure for enlarging a narrowed arterial lumen by peripheral introduction of a balloon-tip catheter followed by dilation of the lumen as the inflated catheter tip is
: report of complications from the National Heart, Lung, Blood Institute PTCA PTCA
abbr.
percutaneous transluminal coronary angioplasty


PTCA Percutaneous transluminal coronary angioplasty, see there
 registry. Circulation 1983; 67: 723-30.

(4.) Pretty HC. Dissecting aneurysm of coronary artery in a woman aged 42. Br Med J 1931; 1: 667.

(5.) Lakshmi V, Umesan CV, Radhakrishnan N, Dhas L, Ajit SM, Cherian KM. spontaneous coronary artery dissection: An institutional review. Indian Heart J 2001; 53: 567.

(6.) Celic SK, Sagcan A, Altintig A, Yuksel M, Akin M, Kultursay H. Primary spontaneous coronary artery dissections in atherosclerotic patients. Report of nine cases with review of the literature. Eur J Cardiothoracic S 2001; 20: 573-6.

(7.) Maehara A, Mintz GS, Castagna MT. Intravascular ultrasound assessment of spontaneous coronary artery dissection. Am J Cardiol 2002; 89: 466-8.

(8.) Zampieri P, Aggio S, Roncon L, Rinuncini M, Canova C, Zanazzi G, et al. Follow up after spontaneous coronary artery dissection: a report of five cases. Heart 1996; 75: 451-4.

(9.) Vale PR, Baron DW. Coronary artery stenting for spontaneous coronary artery dissection: case report and review of the literature. Cathet Cardiovasc Diagn 1998; 45: 280-6.

(10.) DeMaio SJ, Kinsella SH, Silverman ME. Clinical course and long-term prognosis of spontaneous coronary artery dissection. Am J Cardiol 1989; 64: 471-4.

Zeynep Tartan, Hulya Kasikcioglu, Fikri Yapici *, Nese Cam

From Departments of Cardiology and * Cardiovascular Surgery, Siyami Ersek Cardiovascular and Thoracic Surgery Center, Istanbul, Turkey

Address for Correspondence/Yazisma Adresi: Zeynep Tartan, MD, Acibadem Cad. Gunal sokak Billur Sitesi B Blok No:4 Acibadem, Istanbul, Turkey Phone: +90 505 477 90 96 Fax: +90 216 330 74 73 E-mail: drztartan@yahoo.com
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Title Annotation:Case Reports / Olgu Sunumlari
Author:Tartan, Zeynep; Kasikcioglu, Hulya; Yapici, Fikri; Cam, Nese
Publication:The Anatolian Journal of Cardiology (Anadolu Kardiyoloji Dergisi)
Article Type:Clinical report
Geographic Code:7TURK
Date:Dec 1, 2007
Words:1752
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