Spire Named in Top 100 Nanotechnology Public Companies; Spire Derives Revenue from Products and Services Based upon Nanotechnology.

BEDFORD, Mass. -- Spire Corporation (Nasdaq: SPIR), today announced that it has been named one of the 100 leading nanotechnology public companies by The International Association of Nanotechnology.

The selection is based on five criteria: (1) current involvement in R&D, manufacturing, and marketing of nanotechnology products and services; (2) intellectual property position in nanotechnology; (3) advanced engineering processes in nanotechnology and nanoscale manufacturing and production; (4) impact in the marketplace; (5) sales and revenue derived from nanotechnology products or services.

Spire delivers nanotechnology-based products and services to customers in medicine, telecommunication, and alternative energy. Spire's nano-structured coatings and nano-engineered surface treatments improve the performance of thousands of medical implants annually, including orthopedic prosthetics, medical catheters, and cardiovascular grafts. Spire has developed a number of nano-biomaterials for bone and tissue engineering and for drug delivery. The Company is a pioneer in the growth and processing of nano-scaled semiconductor-based materials, such as quantum cascade epitaxial structures, which enable the fabrication of many advanced optoelectronic devices including terahertz lasers and detectors. Spire also produces nanostructured materials that have applications in the fabrication of solar cells with greater efficiency than conventional devices while providing color options for improved aesthetics when integrated into building designs.

Roger G. Little, Chairman and CEO of Spire Corporation, said, "Spire is pleased to be recognized as a leader in the fast growing nanotechnology field, sharing the Top 100 list with other industry leaders including 3M, BASF, Dupont, Motorola, and many others. Spire has a rich heritage of applying science and research to develop innovative products that have put us in the forefront in a number of fields, including solar energy, biomedical devices and services, and optoelectronics."

ABOUT SPIRE CORPORATION

Spire Corporation is a diversified technology company providing innovative solar energy manufacturing equipment, biomedical devices and optoelectronic components, all based upon a common technology platform. For more information visit www.spirecorp.com.

Certain matters described in this news release may be forward-looking statements subject to risks and uncertainties that could cause actual results to differ materially from those indicated in the forward-looking statements. Such risks and uncertainties include, but are not limited to, the risk of dependence on market growth, competition and dependence on government agencies and other third parties for funding contract research and services, as well as other factors described in the Company's Form 10-KSB filed with the Securities and Exchange Commission.