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Silico Insights Attracts Industry and Academic Luminaries to Scientific Board.


Business/Technology Editors and Health/Medical Writers

WOBURN, Mass.--(BW HealthWire)--Nov. 28, 2001

David Schoenfeld of Harvard Medical School Harvard Medical School (HMS) is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts. , Cathy Wu of Georgetown University Georgetown University, in the Georgetown section of Washington, D.C.; Jesuit; coeducational; founded 1789 by John Carroll, chartered 1815, inc. 1844. Its law and medical schools are noteworthy, and its archives are especially rich in letters and manuscripts by and  and Sudhir Saharabudhe of Myriad Genetics Myriad Genetics is a leading biopharmaceutical company focused on understanding the relationship between genes, proteins and human diseases in order to develop the next generation of therapeutic and molecular diagnostic products. , Inc. to provide

scientific and strategic counsel

Silico Insights, Inc., a provider of innovative bioinformatics solutions announced today the appointment of three new highly accomplished professionals to its Scientific Board. Silico Insights will draw on the wealth of scientific knowledge and business experience of its board of scientific members, boosting the company's aggressive growth plans to enable pharmaceutical companies to accelerate drug discovery through the integrated analysis of genomic, proteomic and clinical information.

"Being able to tap into the tremendous pool of expertise presented by Dr. David Schoenfeld, Dr. Cathy Wu and Dr. Sudhir Sahasrabudhe is invaluable to the growth of Silico Insights," said Dr. Nandan Padukone, President and co-founder of Silico Insights. "At this critical juncture, where we are poised to make significant strides, the cumulative vision of our Scientific Board will be a tremendous asset in boosting our success, and I welcome them aboard."

Dr. Sudhir Sahasrabudhe serves as Executive Vice President of Research of Myriad Genetics, Inc. where he oversees all research and product development programs. Prior to Myriad, Dr. Sahasrabudhe was a Senior Director of Biotechnology at Aventis Pharmaceuticals, where he was responsible for all biotechnology activities within the US. He represented Aventis on the board of the SNP SNP Scottish National Party

Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily
 Consortium founded with the aim of discovering Single Nucleotide Polymorphisms throughout the human genome The human genome is the genome of Homo sapiens, which is composed of 24 distinct pairs of chromosomes (22 autosomal + X + Y) with a total of approximately 3 billion DNA base pairs containing an estimated 20,000–25,000 genes. . Dr. Sahasrabudhe also oversaw the Cambridge Genomics Center for Aventis, as well as programs in transgenics trans·gen·ics  
n. (used with a sing. or pl. verb)
The study of or methodology used to create transgenic animals or plants.
, gene expression and disease genomics. In his seven years with Hoechst AG, Dr. Sahasrabudhe held several important positions, including Head of the CNS See Continuous net settlement.

CNS

See continuous net settlement (CNS).
 Molecular Biology molecular biology, scientific study of the molecular basis of life processes, including cellular respiration, excretion, and reproduction. The term molecular biology was coined in 1938 by Warren Weaver, then director of the natural sciences program at the Rockefeller  department.

"One of the biggest challenges drug development companies face is being able to sift through highly disparate data as part of efficiently identifying and developing a drug," said Dr. Sudhir Sahasrabudhe. "Without the right technologies, drug development companies will struggle to leverage all the genome-based information to develop effective drug targets. Silico Insights has demonstrated that they can add significant value to this complex process and I'm excited to be part of this promising venture and the highly driven team of professionals."

Cathy Wu serves as Professor of Biochemistry and Molecular Biology at Georgetown University Medical Center Georgetown University Medical Center (GUMC) is the medical campus at Georgetown University. It is co-located with Georgetown University Hospital on the University's main campus in Washington, DC.  as well as Vice President of National Biomedical Research Foundation (NBRF NBRF National Biomedical Research Foundation ). Dr. Wu has led the development of the Protein Information Resource (PIR "Parent in room." See digispeak. ) database - the world's largest publicly available protein sequence database. She has conducted bioinformatics research since 1990 and developed several systems including the patented MOTIFIND neural network, GeneFIND protein family identification system, and ProClass/iProClass protein family databases. Dr. Wu is the author of patents, book chapters and over 50 publications on bioinformatics and molecular biology. Her proven expertise and leadership in building and utilizing repositories of disparate proteomic information in scientific research will help guide the future development of Silico Insights' platform.

Dr. David Schoenfeld is a Professor in the Department of Medicine at Harvard Medical School and in the Department of Biostatistics at Harvard School of Public Health The Harvard School of Public Health is (colloquially, HSPH) is one of the professional graduate schools of Harvard University. Located in Longwood Area of the Boston, Massachusetts neighborhood of Mission Hill, next to Harvard Medical School and Cambridge, Massachusetts, . He has developed novel statistical and graphical techniques for clinical applications. He directs the Clinical Coordinating Center for the ARDS Ards

District (pop., 2001: 73,244), Northern Ireland. Formerly part of County Down, Ards was established as a district in 1973. Much of its land is devoted to crops and pasture. Newtownards, settled c. 1608 by Scots, is its administrative seat and manufacturing centre.
 Clinical Network, a national group conducting clinical trials for Adult Respiratory Distress Syndrome Adult Respiratory Distress Syndrome Definition

Adult respiratory distress syndrome (ARDS), also called acute respiratory distress syndrome, is a type of lung (pulmonary) failure that may result from any disease that causes large amounts of fluid to
. He also collaborates with diverse groups at Massachusetts General Hospital Massachusetts General Hospital Health care The major teaching hospital for Harvard Medical School, widely regarded as one of the best health care centers in the world , including the Clinical Research Center, the Endocrine division, the Transplant Program, and the Coordinating Center for the Cancer Genetics Network. Dr. Schoenfeld is also a founder and Scientific Director of Boston Biostatistics, Inc., a leading CRO in Massachusetts. He has wide interests in extending statistical and data mining techniques into pharmacogenomics, molecular toxicity and post-approval monitoring.

Previous appointments to the Scientific Board include:
- Leslie Benet, Ph.D., Chairman, Department of Biopharmaceutical Sciences,
UCSF. Dr. Benet is a world-renowned clinical pharmacologist with wide research
interests and more than 400 publications in the areas of pharmacokinetics,
biopharmaceutics, and pharmacodynamics. His work addresses unique problems in
immunosuppression, anti-cancer, anti-AIDS and anti-parasitic drugs, as well as
women's health.

- Mario Schkolnick, Ph.D., CEO, MS3 and former Director of Engineering, Silicon
Graphics, Inc. (SGI) is well known for his contributions in the areas of Data
Mining, Data Base Design and Optimization.

- Foster Provost, Ph.D., Stern School of Business, NYU is an internationally
recognized expert on data mining, knowledge systems, and machine learning.


About Silico Insights

Silico Insights, Inc., based in Woburn, MA, is a provider of innovative web-enabled informatics solutions that enable drug companies to build disease pathways and drug targets based on integrated analysis of genomic, proteomic and clinical information. The company's bioinformatics platform consists of powerful algorithms for integration of disparate data and analysis and visualization of complex correlations in scientific data. This proprietary informatics platform has been applied successfully to both drug discovery and clinical data. The platform elucidates gene function, protein interactions and pathways in disease responses. Silico Insights has established a steady clientele within pharmaceutical and biotechnology companies to build information efficiencies leading to accelerated drug development and market approval.

For more information visit the web site at www.silicoinsights.com or send an e-mail to info@silicoinsights.com.
COPYRIGHT 2001 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2001, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Nov 28, 2001
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