Shire Pharmaceuticals Selects Allscripts For Strategic eMarketing Solution.

CHICAGO -- Allscripts (Nasdaq:MDRX), the leading provider of clinical software, connectivity and information solutions that physicians use to improve healthcare, today announced that its Physicians Interactive(TM) Group has been selected by Shire Pharmaceuticals, a leading global specialty pharmaceutical company, to design, deploy and support a strategic eMarketing solution for Shire's US business.

The Agreement calls for Physicians Interactive to deliver its turn-key Enterprise eMarketing Solution to be leveraged for Shire's online marketing programs to US physicians. The Enterprise eMarketing Solution can support a full suite of online management tools, including product updates, physician communication and education, sample and rep requests, as well as eDetailing(TM) opportunities. All of these eMarketing services are driven through a sophisticated "physician-centric" relational database.

The Enterprise eMarketing Solution increases Shire's value to physicians by providing convenient access to strategic product education and resources online. This solution is driven by physician preferences and dynamically deploys the right information and education at the right time. Services are available to physicians 24 hours a day, seven days a week, and providing Shire real-time reporting to continually learn the needs of the physicians they serve on a day-to-day basis.

"At Shire, our mission is to be the best at meeting the needs of specialty physicians," stated Bob Harrell, Director of eMarketing for Shire. "The Enterprise e-Marketing Solution from Allscripts allows us to provide clinical information and education to our specialty audiences online, complementing our direct field force and other non-personal promotion efforts. The rich functionality of this platform gives us a powerful means to deploy programs for physicians across various Shire products."

Allscripts can deploy the Enterprise e-Marketing platform through a hosted ASP-model or through a software license. A team of system developers, database experts, and implementation personnel provides a turn-key set of services to bring the platform live in as little as 90 days.

"We are very pleased to be partnering with Shire, a market leader in specialty pharmaceuticals," stated Mark Thierer, President of Allscripts Physicians Interactive Group. "With the deployment of Allscripts' Enterprise e-Marketing Solution, Shire is extending its leadership position by acquiring a platform that allows them to build an "Electronic Dialogue" with physicians."

About Shire

Shire's strategic goal is to become the leading specialty pharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on central nervous system (CNS), gastrointestinal (GI), general products (GP) and human genetic therapies (HGT) - all being areas in which Shire has a commercial presence. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire believes that a carefully selected portfolio of products with a strategically aligned and relatively small-scale sales force will deliver strong results. Shire's focused strategy is to develop and market products for specialty physicians. This approach aims to deliver increased returns and lower risks. Shire's in-licensing and merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. For further information on Shire, please visit the Company's website: www.shire.com.

About Allscripts

Allscripts is the leading provider of clinical software, connectivity and information solutions that physicians use to improve healthcare. The Company's business groups provide unique solutions that inform, connect and transform healthcare. The Clinical Solutions Group's award-winning clinical software applications include Electronic Health Record, e-prescribing and document imaging solutions. Additionally, Allscripts provides clinical product education and connectivity solutions for physicians and patients through its Physicians Interactive(TM) Group and medical fulfillment services through its Medication Services Group. To learn more, visit Allscripts on the Web at www.allscripts.com.

This announcement may contain forward-looking statements about Allscripts that involve risks and uncertainties. These statements are developed by combining currently available information with Allscripts beliefs and assumptions. Forward-looking statements do not guarantee future performance. Because Allscripts cannot predict all of the risks and uncertainties that may affect it, or control the ones it does predict, Allscripts' actual results may be materially different from the results expressed in its forward-looking statements. For a more complete discussion of the risks, uncertainties and assumptions that may affect Allscripts, see the Company's 2004 Annual Report on Form 10-K, available through the Web site maintained by the Securities and Exchange Commission at www.sec.gov.