Shin Nippon Biomedical Laboratories, Takeda Pharmaceutical Successfully Complete Joint Research on Cynomolgus Monkey.Tokyo, Japan, June 26, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - Shin Nippon Biomedical bi·o·med·i·cal adj. 1. Of or relating to biomedicine. 2. Of, relating to, or involving biological, medical, and physical sciences. Laboratories (SNBL SNBL Sioux City and New Orleans Barge Line SNBL Snow Blower Unit (on mine trains) ) announced on June 26 that it has completed a joint research project with Takeda Pharmaceutical. Since 2002, the two companies have collaborated in the search and analysis of organ-specific virulence-associated genes of cynomolgus ("crab-eating") monkeys. The aim of this collaboration is to develop an effective tool for analyzing and estimating the toxicity of drug candidates. Through the four-year collaboration, the partners have analyzed genes expressed in the six main organs of cynomolgus monkeys and established a database that covers the entire genome sequences of cynomolgus monkey. Further, they have created a customized DNA microarray DNA microarray A small solid support, usually a membrane or glass slide, on which sequences of DNA are fixed in an orderly arrangement. DNA microarrays are used for rapid surveys of the expression of many genes simultaneously, as the sequences contained on a that mounts representative sequences from 15,000 genes. Subsequently, they have confirmed that the customized DNA microarray can be used to evaluate toxicity in primates. Further, they have developed a gene expression database for 27 organs used in toxicity analysis. Details of the joint research were presented at the 46th Annual Meeting of the Society of Toxicology toxicology, study of poisons, or toxins, from the standpoint of detection, isolation, identification, and determination of their effects on the human body. Toxicology may be considered the branch of pharmacology devoted to the study of the poisonous effects of drugs. and will be presented at the 33rd Annual Meeting of the Japanese Society of Toxicology, to be held in Nagoya in July. Going forward, SNBL plans to proceed with research and aims to develop an innovative tool for toxicity analysis of drug candidates. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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