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Sepracor awarded patent for R-ondasentron, its eleventh U.S. patent for an improved form of an FDA-approved drug; Patent reinforces Sepracor's proprietary position in pharmaceutical marketplace.

MARLBOROUGH, Mass.--(BUSINESS WIRE)--Dec. 14, 1995--Sepracor Inc., (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: SEPR SEPR Senior Enlisted Performance Report ), today announced that it has been granted its eleventh U.S. patent for an Improved Chemical Entity (ICE ), an improved form of an FDA-approved drug. The patent, No. 5,470,868, covers the use of R-ondansetron as an antiemetic.

Marketed by Glaxo Wellcome as Zofran, racemic racemic /ra·ce·mic/ (ra-se´mik) optically inactive, being composed of equal amounts of dextrorotatory and levorotatory isomers.

adj. Abbr.
 ondansetron is a leading antiemetic used to treat nausea and vomiting Nausea and Vomiting Definition

Nausea is the sensation of being about to vomit. Vomiting, or emesis, is the expelling of undigested food through the mouth.
 associated with chemotherapy treatments and surgery. Sepracor estimates that emesis emesis /em·e·sis/ (em´e-sis) vomiting.

n. pl. em·e·ses
The act or process of vomiting.

The medical term for vomiting.
 occurs in 70 percent of the 3.6 million chemotherapy episodes and 30 percent of the 23 million surgical procedures performed in the U.S. each year. The sales of Zofran in 1994 were approximately $600 million.

Despite its effectiveness for emesis, racemic ondansetron has shown a meaningful incidence of adverse side effects such as tachycardia, angina and electrocardiographic electrocardiographic

emanating from or pertaining to electrocardiography.

electrocardiographic monitoring
maintenance of a more or less continuous surveillance of a patient's cardiac status by means of electrocardiography.
 alterations, including second-degree heart block which is most prevalent in nonchemotherapy uses. Sepracor believes that the single isomer isomer (ī`səmər), in chemistry, one of two or more compounds having the same molecular formula but different structures (arrangements of atoms in the molecule). Isomerism is the occurrence of such compounds.  of ondansetron provides an opportunity for development of a safer, more effective antiemetic.

"This patent reinforces our proprietary position in the pharmaceutical marketplace and furthers our strategy to develop safer, purer and more effective versions of already popular and proven therapeutics," said Timothy J. Barberich, Sepracor's President and Chief Executive Officer. "R-ondansetron shows the potential to become an effective antiemetic with a significantly improved cardiovascular side-effect profile over racemic ondansetron."

Sepracor's preclinical trials have indicated that R-ondansetron has superior antiemetic activity compared with the racemic product, while S-ondansetron causes cardiovascular side effects.

Sepracor develops Improved Chemical Entities (ICE) that are enhanced forms of existing, widely sold pharmaceuticals. ICEs can be developed at significantly less cost, time and risk than New Chemical Entities (NCEs), thus providing a pipeline of new product opportunities with significant market potential. -0-

Zofran is a registered trademark of Glaxo Wellcome plc.

CONTACT: David P. Southwell

Chief Financial Officer

Sepracor Inc.


Jean M. Devine

Director, Investor Relations

Sepracor Inc.

(508) 481-6700
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Publication:Business Wire
Date:Dec 14, 1995
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