Selection of hypertrophic cardiomyopathy patients for myectomy or alcohol septal ablation/Hipertrofik kardiyomiyopatide miyektomi veya alkol septal ablasyonu icin hasta secimi.
This brief review summarizes how patients are selected for myectomy or alcohol septal ablation Alcohol septal ablation is a percutaneous, minimally-invasive treatment performed by an interventional cardiologist to relieve symptoms and improve functional status in severely symptomatic patients with hypertrophic cardiomyopathy (HCM) who meet strict clinical, anatomic and physiologic and reviews results for both procedures. The most recent literature is reviewed for both septal myectomy and alcohol ablation. The mechanisms for obstruction and mitral regurgitation mitral regurgitation
n. Abbr. MR
See mitral insufficiency.
mitral regurgitation Chronic mitral valve regurgitation, mitral insufficiency Cardiology Backflow of blood from the left ventricle to the left as well as the indications for both procedures are reviewed. Septal myectomy gives a more consistent relief of the gradient with very low morbidity and mortality Morbidity and Mortality can refer to:
Of or relating to a septum or septa. ablation. There maybe an increased risk for ventricular arrhythmia ventricular arrhythmia An abnormal, usually rapid, heart rhythm that arises in a ventricle; VAs are often life threatening and 2º to myocardial infarction Examples V tach, V fib post ablation. Septal myectomy is the gold standard for the invasive treatment of hypertrophic cardiomyopathy Hypertrophic Cardiomyopathy Definition
Cardiomyopathy is an ongoing disease process that damages the muscle wall of the lower chambers of the heart. . Septal ablation should be considered for the elderly or patients with co-morbid conditions that would make surgery at increased risk. (Anadolu Kardiyol Derg 2006; 6 Suppl 2: 27-30)
Key words: Hypertrophic cardiomyopathy, myectomy, alcohol septal ablation
Bu derleme hipertrofik kardiyomiyopatide hastalarin miyektomi ya da alkol septal ablasyonu icin nasil secildigini ve her iki islemin sonuclari ni ozetlemektedir. Septal miyektomi ve alkol ablasyonu ile ilgili en son literatur gozden gecirilmistir. Obstruksiyon ve mitral mitral /mi·tral/ (mi´tril) shaped like a miter; pertaining to the mitral valve.
1. Relating to a mitral valve.
2. Shaped like a bishop's miter. yetmezligine yol acan mekanizmalar ve her iki islem icin endikasyonlar ele alinmistir. Septal miyektomi cok dusuk morbidite ve mortalite ile gradiyentte daha belirgin azalma saglar. Alkol septal ablasyonunda gorulen mortalite cerrahiden daha yuksektir. Ek olarak, septal ablasyonu uygulanan hastalarda kalici pil icin gereksinim daha fazladir. Ablasyon sonrasi ventrikuler aritmi riski de artabilir. Sonuc olarak, septal miyektomi hipertrofik kardiyomiyopatinin invazif tedavisi icin altin standarttir. Septal ablasyonu cerrahi acidan yuksek riskli olan yasli ya da ek baska hastaliklari olan hastalarda dusunulmelidir. (Anadolu Kardiyol Derg 2006; 6 Ozel Sayi 2: 27-30)
Anahtar kelimeler: Hipertrofik kardiyomiyopati, miyektomi, alkol septal ablasyonu
Hypertrophic Cardiomyopathy is a disease of the heart muscle first recognized by Dr. Donald Teare (1) and Lord Russell Brock (2) in 1957. In some, but not all patients, it is genetically based. It occurs in 1 in 500 people (3). It can occur in young children as well as elderly people. Patients maybe asymptomatic or have severe symptoms of left ventricular (LV) outflow tract outflow tract
the vascular structures associated with movement of blood from the ventricles. See also ventricular outflow obstruction. obstruction which includes shortness of breath Shortness of Breath Definition
Shortness of breath, or dyspnea, is a feeling of difficult or labored breathing that is out of proportion to the patient's level of physical activity. , chest pain dizziness or syncope syncope
Effect of temporary impairment of blood circulation to a part of the body. It is often used as a synonym for fainting, which is loss of consciousness due to inadequate blood flow to the brain. . The first symptom can be sudden death (4). The manifestations of the disease can be worse in the young than the elderly (5). Approximately 70% of patients suffer from left ventricular outflow tract A ventricular outflow tract is a portion of either the left or right ventricle of the human heart through which blood passes in order to enter the great arteries.
The right outflow tract is an infundibular extension of the ventricular cavity, which connects to the pulmonary obstruction at rest or with provocation (6). Obstruction is the result of a complex interaction between the septum septum /sep·tum/ (sep´tum) pl. sep´ta [L.] a dividing wall or partition.
alveolar septum interalveolar s. and the mitral valve leaflets Mitral valve leaflets
The mitral valve is made up of two valve leaflets (the anteromedial leaflet and the posterolateral leaflet) and a ring around the valve, known as the mitral valve annulus. and its supporting structures, the chordae tendineae and the papillary muscles (7-9). In addition, many obstructed patients have significant mitral regurgitation due to systolic Systolic
The phase of blood circulation in which the heart's pumping chambers (ventricles) are actively pumping blood. The ventricles are squeezing (contracting) forcefully, and the pressure against the walls of the arteries is at its highest. anterior motion of the mitral valve (10-12).
The first line of treatment for the obstructive form of the disease is medical treatment with either beta blocker (13-17), calcium channel blockers Calcium Channel Blockers Definition
Calcium channel blockers are medicines that slow the movement of calcium into the cells of the heart and blood vessels. (verapamil verapamil /ve·rap·a·mil/ (ve-rap´ah-mil) a calcium channel blocker that dilates coronary arteries and decreases myocardial oxygen demand, used as the hydrochloride salt in the treatment of angina pectoris and of hypertension and the or diltiazem) (18, 19) or disopyramide (20-23). When patients become refractory to medical treatment, invasive therapy is necessary. The two forms of invasive therapy are septal myectomy and alcohol septal ablation. The latter has also been called PTMSA (Percutaneous Transluminal transluminal /trans·lu·mi·nal/ (trans-loo´mi-n'l) through or across a lumen, particularly of a blood vessel.
Passing or occurring across a lumen. Septal Myocardial myocardial /myo·car·di·al/ (-kahr´de-al) pertaining to the muscular tissue of the heart.
pertaining to the muscular tissue of the heart (the myocardium). Ablation) (24), TASH (Transcoronary Ablation of Septal Hypertrophy hypertrophy (hīpûr`trəfē), enlargement of a tissue or organ of the body resulting from an increase in the size of its cells. Such growth accompanies an increase in the functioning of the tissue. ) (25), and NSRT NSRT Nothing Significant to Report
NSRT North Shore Round Table
NSRT Nebraska Society of Radiologic Technolgists
NSRT Naval Ship Repair Team (Nonsurgical Septal Reduction Therapy) (26).
Before considering, which invasive form of treatment should be used a thorough understanding of the mechanisms for outflow tract obstruction and mitral regurgitation is required.
Mechanisms of Obstruction
Early in the history of the disease, it was proposed that left ventricular outflow tract obstruction was the result of Venturi venturi
a tube with a decrease in the inside diameter that is used to increase the flow velocity of the fluid and thereby cause a pressure drop; used to measure the flow velocity (a venturimeter) or to draw another fluid into the stream. forces being exerted on the leaflets by the rapid flow of blood through the narrow left ventricular outflow tract. This may be the case when the outflow tract is quite narrow as in older patients. These patients frequently also have calcification calcification /cal·ci·fi·ca·tion/ (kal?si-fi-ka´shun) the deposit of calcium salts in a tissue.
dystrophic calcification of the mitral annulus annulus /an·nu·lus/ (an´u-lus) pl. an´nuli [L.] anulus.
an·nu·lus or an·u·lus
n. pl. an·nu·lus·es or an·nu·li
A circular or ring-shaped structure. that may displace the mitral valve anteriorly towards the septum, resulting in marked narrowing of the outflow tract. In many patients, however, either because of large billowing bil·low
1. A large wave or swell of water.
2. A great swell, surge, or undulating mass, as of smoke or sound.
v. bil·lowed, bil·low·ing, bil·lows
1. mitral leaflets and/or anteriorly displaced papillary muscles, there are drag forces that result in anterior motion of the mitral valve (9, 27, 28). In addition, there are patients who have anomalous direct attachment of a papillary muscle to the anterior leaflet (29).
Mechanisms of Mitral Regurgitation
Mitral regurgitation may be the result of the systolic anterior motion (SAM) of the mitral valve leaflets or there may be intrinsic mitral valve disease. If the mitral regurgitation is related to SAM the mitral regurgitant regurgitant /re·gur·gi·tant/ (re-ger´ji-tint) flowing backward.
flowing back. jet is directed posterior and laterally (11). If the regurgitation regurgitation /re·gur·gi·ta·tion/ (re-ger?ji-ta´shun)
1. flow in the opposite direction from normal.
2. vomiting. is related to intrinsic mitral valve disease, the jet will be central or anteromedially directed. It is particularly important to know the mechanism of the regurgitation. When the regurgitation is related to the SAM then it will be improved or eliminated when the septum is surgically thinned. However, when there is co-existent mitral valve disease it will not be improved with septal reduction therapy alone. In addition to jet direction, the mitral valve anatomy must be completely visualized. This may require a transesophageal echocardiography if the transthoracic transthoracic /trans·tho·rac·ic/ (-thah-ras´ik) through the thoracic cavity or across the chest wall.
Across or through the thoracic cavity or chest wall. study is not ideal.
Surgery for Hypertrophic Cardiomyopathy
The gold standard for medically refractory disease is a septal myectomy. It has been done for more than forty years. Early results of surgery had operative mortality in the range of 8% (30). Subsequent surgical series have had a mortality of <2% (31,32). Smedira and colleagues, in 324 patients, had no hospital deaths (33). The results of surgery are clearly improved from earlier times because of better anesthesia, myocardial protection during cardiopulmonary bypass and intra-operative transesophageal echocardiography (34) The anesthesia and myocardial protection reduce the risk of ischemia during surgery. The intra-operative transesophageal echocardiography allows for the surgeon and the cardiologist to be sure that the septal myectomy and mitral valve surgery, if required, are adequate before the patient leaves the operating room. The latter has significantly reduced the need for re-operation. The series by Ommen and colleagues (31) showed that patients with successful myectomy live as long as the age-adjusted general population.
Alcohol Septal Ablation for Hypertrophic Cardiomyopathy
We feel that elderly patients, or those with severe co-morbid conditions who would be at increased surgical risk, should be considered for alcohol ablation. They should be NYHA NYHA New York Heart Association function class III or IV with a gradient of 50 mm Hg at rest or with provocation. These would be patients, however, who have no co-existent valvular heart disease Valvular Heart Disease Definition
Valvular heart disease refers to several disorders and diseases of the heart valves, which are the tissue flaps that regulate the flow of blood through the chambers of the heart. or coronary artery disease coronary artery disease, condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue. . We have considered patients for ablation because of morbid obesity, diabetes, chronic obstructive pulmonary disease chronic obstructive pulmonary disease
n. Abbr. COPD
A chronic lung disease, such as asthma or emphysema, in which breathing becomes slowed or forced. or renal failure (35). In order for the ablation to be successful there must be a septal perforator per·fo·rate
v. per·fo·rat·ed, per·fo·rat·ing, per·fo·rates
1. To pierce, punch, or bore a hole or holes in; penetrate.
2. of sufficient size and location to cause an infarction of the septum in the area of SAM--septal contact in order to reduce the left ventricular outflow tract obstruction. When the septum is less than 18 mm, intrinsic mitral valve disease should be strongly suspected. Usually this means the leaflets are elongated e·lon·gate
tr. & intr.v. e·lon·gat·ed, e·lon·gat·ing, e·lon·gates
To make or grow longer.
adj. or elongated
1. Made longer; extended.
2. Having more length than width; slender. or anteriorly displaced. If the septum is greater than 25 mm the chance for successful, meaningful, septal reduction by alcohol will be reduced.
The first three cases of septal ablation were first described by Sigwart (36) after first recognizing that spontaneous myocardial infarction could reduce the left ventricular outflow tract obstruction. Over the past 11 years, greater than 3500 patients have undergone the procedure.
First, a coronary angiogram an·gi·o·gram
An angiographic x-ray of blood vessels used in diagnosing pathological conditions of the cardiovascular system.//An x-ray of one or more blood vessels produced by angiography and used in diagnosing pathology in the cardiovascular is done to insure there is no significant intrinsic coronary artery disease. A temporary pacemaker is placed in the right ventricle should the patient develop complete heart block. A transthoracic echocardiography is performed in the catheterization catheterization
Threading of a flexible tube (catheter) through a channel in the body to inject drugs or a contrast medium, measure and record flow and pressures, inspect structures, take samples, diagnose disorders, or clear blockages. laboratory to define the location of SAM septal contact. Then a small catheter is placed in the left anterior descending coronary artery Left anterior descending coronary artery (LAD)
One of the heart's coronary artery branches from the left main coronary artery which supplies blood to the left ventricle.
Mentioned in: Cardiac Catheterization with the help of a guiding catheter. It is then usually advanced into the first septal perforator. The balloon is inflated. An echocardiography Echocardiography Definition
Echocardiography is a diagnostic test that uses ultrasound waves to create an image of the heart muscle. Ultrasound waves that rebound or echo off the heart can show the size, shape, and movement of the heart's valves and contrast agent is then injected to determine where the myocardial infarction will occur. It must be determined that the contrast only goes to the septum near the point of mitral-septal contact and not elsewhere; for example, not to the right ventricle, LV papillary muscles or in the LV free wall. Once it is determined that the catheter is in proper position, 1-3 cc of absolute ethyl alcohol is slowly injected down the catheter. As the alcohol is injected echocardiography is repeated and a very bright area is seen where the infarction will occur. The balloon is inflated for 10 minutes, then carefully removed. Usually, with initial balloon inflation the gradient drops significantly. It has been observed that at about five days the gradient goes back up and then slowly falls over the next few weeks to months. The initial drop is thought to be the result of initial stunning. The redevelopment of the gradient may be the result of edema edema (ĭdē`mə), abnormal accumulation of fluid in the body tissues or in the body cavities causing swelling or distention of the affected parts. in the infarcted area; then, the subsequent drop in the gradient may be the result of formation of scar and retraction of the infarcted area.
There has been early enthusiasm for septal ablation. It is clearly less invasive than surgery and many patients recover quickly. A number of studies have shown positive results in terms of symptom reduction. However, on closer scrutiny there are problems to be considered. The reported mortality with the procedure is higher than with a septal myectomy. There is less complete relief of the gradient and the need for permanent pacemaker is higher (25, 26, 37-39). In our experience the technique is successful 80% of the time (35).
In addition to these early studies there have been single center non-randomized studies comparing alcohol ablation to septal myectomy. All have shown better relief of gradient, lower incidence of heart block and lesser mortality in the surgical group (35, 40). One study showed better exercise tolerance post myectomy (41). There also remains the worry of sudden death after ablation. The incidence is not clear, but there are individual case reports of sudden deaths after ablation. In many of the series at least one sudden death has occurred and sometimes more (42, 43, 44) There are also series of patients who were considered at high risk for sudden death who had an automated implantable cardioverter-defibrillator (AICD AICD activation-induced cell death; automatic implantable cardioverter-defibrillator. ) implanted: the firing rate in the first year post ablation was high--8% (45).
Advantages of a Septal Myectomy
The relief of the gradient is immediate and usually permanent. Need for a permanent pacemaker is less than 3% if there are no preexisting pre·ex·ist or pre-ex·ist
v. pre·ex·ist·ed, pre·ex·ist·ing, pre·ex·ists
To exist before (something); precede: Dinosaurs preexisted humans.
v.intr. conduction abnormalities. Co-existing coronary artery disease and mitral valve disease can be dealt with. There is no scar that remains and the patient is thus at less risk for ventricular arrhythmia.
Disadvantages of a Septal Myectomy
Surgery requires an experienced surgeon, who may not be locally available. The risk is higher in the elderly patients. The incidence of post-operative atrial fibrillation is 22-30%. Mild aortic insufficiency has been reported after surgery. The recovery is longer with surgery than with alcohol ablation.
Advantages of Septal Ablation
The benefits of the ablation are that a major surgical procedure can be avoided. There is no post-operative pain and very little risk of infection or need for blood transfusion. The hospital stay tends to be shorter and therefore there is possibly less expense. There is a quicker return to daily activities. There is a very low incidence of post ablation atrial fibrillation.
Disadvantages of Septal Ablation
Variability in the location and size of the septal perforators is significant. This will, therefore, limit the number of potential candidates for the procedure. In one series of Seggeweiss 3% of the patients could not have ablation because of problems with perforator anatomy (38). Provocable obstruction may remain. The incidence of permanent pacemaker insertion is 10-23%. There remains the concern about the development of ventricular arrhythmia, and there have been reports of sudden death and AICD shocks, days to weeks after ablation.
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emanating from or pertaining to electrocardiography.
maintenance of a more or less continuous surveillance of a patient's cardiac status by means of electrocardiography. and hemodynamic he·mo·dy·nam·ics
n. (used with a sing. verb)
The study of the forces involved in the circulation of blood.
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hypertrophic pulmonary osteoarthropathy
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Harry M. Lever
Cleveland Clinic, Cleveland, Ohio, USA
Address for Correspondence: Harry M Lever, MD, Cleveland Clinic, 9500 Euclid Avenue, Desk F-15 Cleveland, OH, 44195, USA E-mail: firstname.lastname@example.org
Presented in part at "Hypertrophic Cardiomyopathy Treatment: Medical, Surgical, Sudden Death Prevention and New Modalities" sponsored by St. Luke's--Roosevelt Hospital Center, Columbia University, College of Physicians and Surgeons College of Physicians and Surgeons: see Columbia Univ. , New York City New York City: see New York, city.
New York City
City (pop., 2000: 8,008,278), southeastern New York, at the mouth of the Hudson River. The largest city in the U.S. .