Selected Ongoing Clinical Trials [*].HYPERTENSION * TREATMENT OF HYPERTENSION WITH TWO EXERCISE INTENSITIES. This study will determine whether exercise training can significantly replace medication as a treatment for mild essential hypertension. Both men and women aged 18 to 75 years are eligible. Contact: Lisa A. Landsberg, MCP (1) See Microsoft certification. (2) (MultiChip Package) A chip package that contains two or more chips. It is essentially a multichip module (MCM) that uses a laminated, printed-circuit-board-like substrate (MCM-L) rather than ceramic (MCM-C). Hahnemann University, Philadelphia, PA 19102. (215) 871-4303. E-mail: lisa.landsberg@drexel.edu * PREMIER: LIFESTYLE INTERVENTIONS FOR BLOOD PRESSURE CONTROL. This Phase III, multicenter study will compare the effectiveness of advice versus two multicomponent lifestyle interventions to control blood pressure in participants with Stage 1 hypertension or higher than optimal blood pressure. Both men and women aged 25 years and older who are generally healthy except for higher than optimal or mildly elevated blood pressure are eligible. Contact: Jeanne Charleston, Johns Hopkins University Johns Hopkins University, mainly at Baltimore, Md. Johns Hopkins in 1867 had a group of his associates incorporated as the trustees of a university and a hospital, endowing each with $3.5 million. Daniel C. , Baltimore, MD 21218. (410) 281-1600. BREAST CANCER * COMBINATION CHEMOTHERAPY IN TREATING WOMEN WITH BREAST CANCER THAT IS METASTATIC Metastatic The term used to describe a secondary cancer, or one that has spread from one area of the body to another. Mentioned in: Coagulation Disorders metastatic pertaining to or of the nature of a metastasis. OR CANNOT BE TREATED WITH SURGERY. This Phase II, multicenter study will examine the effectiveness of combination chemotherapy in treating women who have breast cancer that is metastatic or cannot be treated with surgery. Women aged 18 years and older who have histologically confirmed breast cancer, metastatic or unresectable local disease, are eligible. Contact: Robert W Tucker, Comprehensive Cancer Center of Wake Forest University Baptist Medical Center This article or section needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article. , Winston-Salem, NC 27157-1082. (910) 716-0286. COLORECTAL CANCER * COMPARISON OF BARIUM ENEMA, COMPUTED TOMOGRAPHIC COLONOGRAPHY, AND COLONOSCOPY IN DETECTING COLON CANCER. This diagnostic and screening, multicenter trial will compare the effectiveness of barium enema, computed tomographic colonography, and colonoscopy in detecting colon cancer. Both men and women aged 18 years and older who have had at least one positive fecal occult blood test Fecal Occult Blood Test Definition The fecal occult blood test (FOBT) is performed as part of the routine physical examination during the examination of the rectum. within the past 6 months and no active gastrointestinal hemorrhage are eligible. Contact: Don Rockey, Duke Comprehensive Cancer Center, Durham, NC 27710. (919) 668-0731. * HIGH-DOSE FOLIC ACID IN PREVENTING COLORECTAL CANCER IN PATIENTS WHO HAVE HAD POLYPS Polyps A tumor with a small flap that attaches itself to the wall of various vascular organs such as the nose, uterus and rectum. Polyps bleed easily, and if they are suspected to be cancerous they should be surgically removed. SURGICALLY REMOVED. This Phase II, randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. trial will study the effectiveness of high-dose folic acid in preventing colorectal cancer in patients who have had polyps surgically removed within 18 months of the trial. Both men and women aged 21 years and older with colonic adenoma adenoma: see neoplasm. (s) of at least 10 mm completely resected within 18 months prior to randomization randomization (ranˈ·d  ·m or suspected adenomatous polyp(s) are eligible.
Contact: Al Bowen Benson III, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL 60611. (312) 695-6180. * CELECOXIB TO PREVENT COLORECTAL CANCER IN PATIENTS WHO HAVE UNDERGONE SURGERY TO REMOVE POLYPS. This randomized, double-blind, placebo-controlled, clinical trial will determine the effectiveness of celecoxib in preventing the development of adenomatous polyps in patients who have had at least one polyp polyp, in medicine, a benign tumor occurring in areas lined with mucous membrane such as the nose, gastrointestinal tract (especially the colon), and the uterus. Some polyps are pedunculated tumors, i.e. removed. Both men and women aged 30 years and older with at least one prior colorectal adenomatous polyp removed by polypectomy within the past 5 months are eligible. Contact: Elliot Kopp, C.A.R.E. Center, Raleigh, NC 27609. (919) 954-1404. * EFLORNITHINE PLUS SULINDAC IN PREVENTING A RECURRENCE OF COLORECTAL CANCER IN PATIENTS WHO HAVE HAD SURGERY TO REMOVE BENIGN COLORECTAL POLYPS. This Phase II, randomized, double-blind trial will determine the efficacy of eflornithine plus sulindac compared to a placebo in preventing colorectal cancer in patients who have had surgery to remove benign col orectal polyps. Both men and women aged 40 to 80 years with at least one prior resected colorectal adenoma within the past 5 years are eligible. Contact: David Samuel Alberts, Arizona Cancer Center, Tucson, AZ 85724. (520) 626-7685. PROSTATE CANCER * DIET AND PSA (Professional Services Automation) An information system designed to organize, track and manage all opportunities, work, resources, costs, revenues and invoices to improve the productivity and efficiency of the workforce. LEVELS IN PATIENTS WITH PROSTATE CANCER. This is a two-year, Phase III, randomized trial that will compare how two diets differing in fat, fiber, soy, fruit, vegetable, vitamin E, and green tea content affect prostate-specific antigen (PSA) levels in patients with prostate cancer. Men aged 18 years and older with histologically confirmed adenocarcinoma of the prostate are eligible. Contact: Howard I. Scher, Memorial Sloan-Kettering Cancer Center The Memorial Sloan-Kettering Cancer Center (MSKCC) in New York City is a cancer treatment and research institution founded in 1884 as the New York Cancer Hospital. The main campus is located at 1275 York Avenue, between 67th and 68th Streets, with other locations in New , New York, NY 10021. (212) 639-7585. * EFLORNITHINE IN TREATING MEN AT HIGH RISK OF DEVELOPING PROSTATE CANCER. This is a Phase II, randomized, double-blind, placebo-controlled study that will determine the effectiveness of eflornithine in preventing prostate cancer in men who are at high risk of developing the disease. Men aged 45 to 70 years with an unaffected brother or first degree cousin of a young prostate cancer proband proband /pro·band/ (pro´band) an affected person ascertained independently of relatives in a genetic study. pro·band n. (under age 70) with a family history (one or more first-degree relatives) of prostate cancer are eligible. Contact: Thomas Edward Ahlering, Chao Family Comprehensive Cancer Center, Orange, CA 92868. (714) 456-6068. LUNG CANCER * CHEMOTHERAPY PLUS RADIATION THERAPY IN TREATING PATIENTS WITH NON-SMALL-CELL LUNG CANCER. This Phase I trial will study the effectiveness of combination chemotherapy plus radiation therapy in treating patients who have stage IIIA IIIA Internet Information Infrastructure Architecture IIIA Integrated Intelligence Information Application IIIA International Imaging Industry Association or stage IIIB non-small-cell lung cancer. Both men and women with histologically confirmed loco-regionally advanced, non-small-cell lung cancer are eligible for the 32-month study. Contact: Marcel E. Conrad, University of South Alabama The University of South Alabama is a public, doctoral-level university in Mobile, Alabama, USA. It was created by the Alabama Legislature in 1963, and replaced existing extension programs operated in Mobile by the University of Alabama. , Mobile, AL 36688. (334) 460-7194. * COMPUTED TOMOGRAPHY FOR EARLY DETECTION OF CANCER IN WOMEN WHO ARE AT RISK FOR LUNG CANCER. This screening and diagnostic study will determine the ability of computed tomography to detect early lung parenchymal pa·ren·chy·ma n. 1. Anatomy The tissue characteristic of an organ, as distinguished from associated connective or supporting tissues. 2. abnormalities in women at high risk for lung cancer. Women aged 18 years and older who currently smoke and have no history of prior lung cancer are eligible. Contact: Abraham Chachoua, NYU NYU New York University NYU New York Undercover (TV show) School of Medicine's Kaplan Comprehensive Cancer Center, New York, NY 10016. (212) 263-6485. * OLTIPRAZ IN THE PREVENTION OF LUNG CANCER IN PEOPLE WHO SMOKE. This randomized, Phase I trial will study the effectiveness of oltipraz in preventing lung cancer in people who smoke. Both men and women aged 18 years and older who currently smoke at least 20 cigarettes a day and have done so for at least 10 years are eligible. Contact: Michael J. Kelley, Duke Comprehensive Cancer Center, Durham, NC 27710. (919) 286-0411, ext. 7331. CANCER * PHYSICIAN-INITIATED STOP-SMOKING PROGRAM FOR EARLY-STAGE CANCER PATIENTS. This randomized study will compare the effectiveness of a physician-initiated stop-smoking program with the usual care for early-stage cancer patients. Both men and women aged 19 years and older who are being seen by a physician for cancer in any of the following groups are eligible: Stage I/II bladder, colorectal, head and neck, or lung cancer; Stage I/II/III testicular cancer; Stage I/II/III/IV breast or prostate cancer; or lymphoma. Participants must have smoked one or more cigarettes within the past month. Contact: Louis M. Weiner, Fox Chase Cancer Center The Fox Chase Cancer Center is a medical research facility and hospital located in the northeast section of Philadelphia, Pennsylvania, United States. The Center is an independent, non-profit institution which specializes in the treatment and prevention of cancer. Philadelphia, PA 19111. (215) 728-2480. * SCREENING FOR CANCER OF THE PROSTATE, LUNG, COLON, RECTUM, OR OVARIES Ovaries The female sex organs that make eggs and female hormones. Mentioned in: Choriocarcinoma ovaries (ō´v IN OLDER PATIENTS. This 16-year randomized trial will determine if screening methods used to diagnose cancer of the prostate, lung, colon, rectum, or ovaries can reduce deaths from] these cancers. Both men and women aged 55 to 74 years with no known prior cancer of the colon, rectum, lung, prostate, or ovaries are eligible. Contact: Edward P Gelmann, Lombardi Cancer Center, Georgetown University, Washington, DC 20007. (202) 687-7664. (*.) Prepared by Elaine McClellan-Holm. |
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