Sea bacteria may be new anticancer resource. (Chemistry).
Many drugs, including the antibiotic streptomycin streptomycin (strĕp'tōmī`sĭn), antibiotic produced by soil bacteria of the genus Streptomyces and active against both gram-positive and gram-negative bacteria (see Gram's stain), including species resistant to other , are derived from soil microbes called actinomycetes Actinomycetes
A heterogeneous collection of bacteria that form branching filaments. The actinomycetes encompass two different groups of filamentous bacteria: the actinomycetes per se and the nocardia/streptomycete complex. . Lately, however, scientists have been wondering whether they have wrung wrung
Past tense and past participle of wring.
the past of wring
wrung wring out all of the drugs possible from these bacteria.
Now, William Fenical and his colleagues at the Scripps Institution of Oceanography Scripps Institution of Oceanography: see California, Univ. of. in La Jolla La Jolla (lə hoi`yə), on the Pacific Ocean, S Calif., an uninc. district within the confines of San Diego; founded 1869. The beautiful ocean beaches, in particular La Jolla shores and Black's Beach, and sea-washed caves attract visitors and , Calif., have found a large source of previously unknown strains of actinomycetes that may make chemicals with antibiotic or cancer-fighting properties.
Fenical discovered the new bacteria, which he dubs Salinospora, in deep ocean sediments collected from all over the globe. In preliminary benchtop tests, many of the 2,500 Salinospora strains identified by Fenical produced potentially therapeutic chemicals.
In additional studies, Fenical and his coworkers determined the chemical structure of one such molecule--salinosporamide A. In test tubes, the molecule strongly inhibited the growth of some cancer cells from human colon, lung, and breast tissues. The researchers describe their results in the Jan. 20 Angewandte Chemie International Edition.
"This is the tip of an iceberg," says Fenical. Salinosporamide A and molecules from other strains of Salinospora might serve as new tools for studying cancer or even as therapeutic drugs themselves one day, he says.--J.G.