Scientists use immune system to reduce prostate cancer risk.
Washington, Sept 24 (ANI): Researchers from the University of Michigan (body, education) University of Michigan - A large cosmopolitan university in the Midwest USA. Over 50000 students are enrolled at the University of Michigan's three campuses. The students come from 50 states and over 100 foreign countries. Comprehensive Cancer Centre have found a novel way to reduce the genetic risk of prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men. .
Typically, vaccines are based on specific antigens and trigger immunity for a specific pathogen.
It is challenging for cancer as the best lymphocytes that generate immunity to cancer are eliminated during development.
The researchers have revealed that rescuing these critical immune system immune system
Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders. cells can help reduce genetic risk of prostate cancer.
They sought to rescue key lymphocytes - called high affinity cancer-reactive T cells - during their development.
During the study, researchers showed that T cells involved in prostate cancer are deleted because of a gene called lymphotoxin lymphotoxin /lym·pho·tox·in/ (lim´fo-tok?sin) tumor necrosis factor ; a lymphokine produced by activated T lymphocytes that it inhibits growth of tumors and blocks transformation of cells. alpha.
When the mice lacked lymphotoxin, these T cells came back. These mice become more resistant to prostate cancer. This result suggests that lymphotoxin can be a good target for immune prevention.
The researchers injected a protein targeting lymphotoxin into cancer-susceptible mice.
Without treatment, all of these mice will develop prostate cancer, and typically by age 6 months half of them will have metastatic cancer that has spread to distant organs. Although the treated mice still developed tumours, none developed metastases Metastasis (plural, metastases)
A tumor growth or deposit that has spread via lymph or blood to an area of the body remote from the primary tumor.
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"It appears that the rescued T cells delay tumour formation. It may not be that this approach can prevent cancer altogether, but it can delay the process and slow the aggressive growth and spread of cancer," said study author Dr Pan Zheng, associate professor of surgery and pathology at the U-M U-M University of Michigan (also seen as UM) Medical School.
"There is a certain population with a high likelihood of getting cancer, and we need better strategies to minimize their risk.
This approach may be translated into clinical care for those patients," Zheng added. (ANI)
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