Scientists develop polymer that delivers genetic medicine, allows tracking.Byline: ANI Washington, October 7 (ANI): Scientists have developed a novel molecule that can travel into cells, deliver genetic cargo, and pack a beacon so that scientists can follow its movements in living systems. This advancement is a result of the efforts of Theresa M. Reineke, associate professor of chemistry in the College of Science, and her colleagues in her lab at Virginia Tech and at the University of Cincinnati The University of Cincinnati is a coeducational public research university in Cincinnati, Ohio. Ranked as one of America’s top 25 public research universities and in the top 50 of all American research universities,[2] . "My lab has been trying to find a way to deliver genetic-based drugs into cells," said Reineke. While studies being conducted across the world are using information from the human genome project as an approach to treat disease, Reineke's focus is cancer and cardiovascular disease Cardiovascular disease Disease that affects the heart and blood vessels. Mentioned in: Lipoproteins Test cardiovascular disease . "Traditional drugs are aimed at treating disease at the protein level. Genetic drugs - such as those that can alter or control gene expression - aim to treat disease at the genetic level and have the added benefit of being more specific for their medicinal target," she said. The scientists created novel polycations, a polymer chain with positive charges, which is not too unusual. DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. itself is a polyanion, a polymer with negative charges. However, the Reineke Group's supramolecule contains chemistry (oligoethyleneamines) that binds and compacts nucleic acids Nucleic acids The cellular molecules DNA and RNA that act as coded instructions for the production of proteins and are copied for transmission of inherited traits. - pieces of the DNA - into nanoparticles. It also incorporates a group of rare-earth elements known as lanthanides. The repackaged DNA is protected from damage as it travels into the cells and the lanthanides allow visualization of the delivery into cells. "In our experiments, these delivery beacons provide the ability to track DNA delivery into living cells. They provide the potential for tracking genetic therapies within the living body," said Reineke. At the cellular scale, the researchers are able to track the polymers using sensitive microscopes, which capture the nanoparticle luminescence luminescence, general term applied to all forms of cool light, i.e., light emitted by sources other than a hot, incandescent body, such as a black body radiator. . At the tissue scale, magnetic resonance imaging magnetic resonance imaging (MRI), noninvasive diagnostic technique that uses nuclear magnetic resonance to produce cross-sectional images of organs and other internal body structures. (MRI 1. (application) MRI - Magnetic Resonance Imaging. 2. MRI - Measurement Requirements and Interface. ) is used to see where the nanoparticles are going. "This ability to track the movement and delivery of a gene-based drug provides an opportunity to understand the mechanism of delivery and monitor efficacy in real time, so that we can develop better materials for delivering genetic therapeutics and ultimately better treatments," Reineke said. (ANI) Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved. Provided by Syndigate.info an Albawaba.com company |
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