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Scientists Who Made Significant Contribution to Discovery of Lantheus Medical Imaging's Cardiolite[R] Honored with Prestigious Nuclear Medicine Award at SNM Annual Meeting.



Lantheus Congratulates Award Recipients For Their Ongoing Commitment to Advancing Field of Nuclear Medicine

N. BILLERICA, Mass. -- Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic imaging, congratulates the team of scientists whose research served as the primary foundation for the development of the company's leading imaging agent, Cardiolite([R]) (Kit for the Preparation of Technetium technetium (tĕknē`shēəm) [Gr. technetos=artificial], artificially produced radioactive chemical element; symbol Tc; at. no. 43; mass no. of most stable isotope 98; m.p. 2,200°C;; b.p. 4,877°C;; sp. gr. 11.  Tc99m Sestamibi for Injection), for receiving the SNM's Georg Charles de Hevesy Nuclear Medicine Pioneer Award. Drs. Michael Abrams, Alan Davison and Alun Jones were presented this prestigious honor for their outstanding contribution to the field of nuclear medicine, specifically their discovery and development of isonitriles, a group of chemical compounds which, when used with the radioisotope radioisotope: see radioactive isotope.
Radioisotope (biology)

A radioactive isotope used in studying living systems, such as in the investigation of metabolic processes.
 technetium-99m, had groundbreaking applications for the field of molecular and nuclear imaging. Dr. Robert Atcher, president of SNM SNM Society of Nuclear Medicine
SNM Show No Mercy (gaming clan)
SNM Special Nuclear Material
SNM Somali National Movement
SNM San Marcos (Guatemala, territorial division)
SNM Service Member
, today presented this award to this group of researchers at the SNM's 56th Annual Meeting, the world's largest society for molecular imaging and nuclear medicine professionals, in Toronto.

"We applaud the team of Abrams, Davison and Jones for their long-standing commitment to the study and advancement of nuclear medicine and their pioneering research that led to the discovery of Cardiolite([R]), which remains at the heart of nuclear imaging after nearly 20 years," said Don Kiepert, president and chief executive officer of Lantheus Medical Imaging, Inc. "Cardiolite([R]) continues to play an integral role in the diagnosis and management of coronary artery disease coronary artery disease, condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue. , and we are proud that this premier group of scientists received such an esteemed award in recognition of their significant research discovery. We believe that Cardiolite([R]) delivers uncompromising quality for clinicians and patients, and thus remains at the forefront of cardiac imaging today."

In the 1980s, the team of Drs. Abrams, Davidson and Jones played a central role in discovering, developing and broadly patenting the chemistry and radiochemistry radiochemistry, chemistry of radioactive substances (see radioactivity). Radioactive isotopes are very useful as tracers to study the mechanisms of complex organic reactions, since even minute amounts of these isotopes are easily detected by means of a Geiger counter  of isonitriles, a group of chemical compounds, that can link with technetium-99m (Tc-99m), which today is the most widely utilized radioisotope in the world for molecular and nuclear diagnostic imaging tests. This important research created the foundation for the discovery of Cardiolite([R]), which was developed by a separate team of chemists from DuPont Radiopharmaceuticals (the predecessor of Lantheus Medical Imaging, Inc.) working in N. Billerica, MA who synthesized novel isonitriles (mibi and sestamibi) and who developed process chemistry for Cardiolite([R]).

Today, Michael J. Abrams, Ph.D. is an Adjunct Professor at the University of British Columbia Locations
Vancouver
The Vancouver campus is located at Point Grey, a twenty-minute drive from downtown Vancouver. It is near several beaches and has views of the North Shore mountains. The 7.
. Alan Davison, Ph.D., is a Professor of Chemistry at the Massachusetts Institute of Technology Massachusetts Institute of Technology, at Cambridge; coeducational; chartered 1861, opened 1865 in Boston, moved 1916. It has long been recognized as an outstanding technological institute and its Sloan School of Management has notable programs in business, . Alun Jones, Ph.D., is Director of the Joint Program in Nuclear Medicine Radiopharmacy and Professor of Radiology at Harvard Medical School Harvard Medical School (HMS) is one of the graduate schools of Harvard University. It is a prestigious American medical school located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts. . He is also Director of the Radiopharmaceutical radiopharmaceutical /ra·dio·phar·ma·ceu·ti·cal/ (-fahr?mah-soo´ti-k'l) a radioactive pharmaceutical, nuclide, or other chemical used for diagnostic or therapeutic purposes.  Chemistry and Radiopharmacy Section of the Laboratory for Experimental Nuclear Medicine.

About The Georg Charles de Hevesy Nuclear Medicine Pioneer Award

Each year, SNM presents the Georg Charles de Hevesy Nuclear Medicine Pioneer Award to an individual (or individuals) for outstanding contributions to the field of nuclear medicine. The Award is named after Dr. de Hevesy, known as the father of nuclear medicine, and the author of several important books and papers on radiochemistry. Dr. de Hevesy was awarded numerous prizes and medals during his career, including the 1943 Nobel Prize in chemistry The Nobel Prize in Chemistry (Swedish: Nobelpriset i kemi) is awarded once a year by the Royal Swedish Academy of Sciences. It is one of the six Nobel Prizes. The first prize was awarded in 1901. .

About Cardiolite([R])

Cardiolite([R]) (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection) is one of the world's most widely-used cardiac imaging agents and the only technetium labeled myocardial myocardial /myo·car·di·al/ (-kahr´de-al) pertaining to the muscular tissue of the heart.

myocardial

pertaining to the muscular tissue of the heart (the myocardium).
 perfusion agent that has been used to image more than 40 million patients. For almost two decades, Cardiolite([R]) has played a vital role in the diagnosis and management of patients with known or suspected coronary artery disease.

Cardiolite([R]) is the first technetium labeled myocardial perfusion tracer to provide physicians with prognostic information that can be helpful in making patient management decisions. Cardiolite([R]) is the subject of more than 10,000 publications and the imaging agent of choice within several post marketing cardiology clinical trials -DIAD, COURAGE, ERASE, INSPIRE and CHRISTMAS - which have resulted in changes in patient care.

Indication and Important Safety Information Regarding Cardiolite([R])

Cardiolite([R])(Kit for the Preparation of Technetium Tc99m Sestamibi for Injection) is a myocardial perfusion agent that is indicated for detecting coronary artery disease by localizing myocardial ischemia myocardial ischemia,
n a loss of oxygen to the heart muscle caused by blockage of the coronary arteries or their branches.

myocardial ischemia 
 (reversible defects) and infarction (non-reversible defects), in evaluating myocardial function and developing information for use in patient management decisions. Cardiolite([R]) evaluation of myocardial ischemia can be accomplished with rest and cardiovascular stress techniques (e.g., exercise or pharmacologic stress in accordance with the pharmacologic stress agent's labeling).

It is usually not possible to determine the age of a myocardial infarction myocardial infarction: see under infarction.  or to differentiate a recent myocardial infarction from ischemia.

Exercise and pharmacologic stress testing should be performed only under the supervision of a qualified physician. Cardiolite([R]) has been rarely associated with acute severe allergic events of angioedema and urticaria urticaria /ur·ti·ca·ria/ (ur?ti-kar´e-ah) hives; a vascular reaction of the upper dermis marked by transient appearance of slightly elevated patches (wheals) which are redder or paler than the surrounding skin and often attended by . The most frequently reported adverse events include headache, chest pain/angina, ST segment changes on ECG ECG electrocardiogram.

ECG
abbr.
1. electrocardiogram

2. electrocardiograph


ECG
Also called an electrocardiogram, it records the electrical activity of the heart.
, nausea, and abnormal taste and smell.

For full prescribing information, please visit www.cardiolite.com. Cardiolite([R])is a registered trademark of Lantheus Medical Imaging, Inc.

About Lantheus Medical Imaging, Inc.

Lantheus Medical Imaging, Inc., a worldwide leader in diagnostic medicine for the past 50 years, is committed to advancing and investing in the field of diagnostic imaging. The company's proven success in discovering, developing and marketing innovative medical imaging agents provides a solid platform from which to bring forward breakthrough new tools for the diagnosis and management of disease. The company is home to leading cardiac imaging brands, including Cardiolite([R]) (Kit for the Preparation of Technetium Tc99m Sestamibi for Injection), DEFINITY([R])Vial For (Perflutren Lipid Microsphere Not to be confused with Glass microphere.
This article largely refers to micropheres or protein protocells as small spherical units postulated by some scientists as a key stage in the origin of life.
) Injectable Suspension, and TechneLite([R])(Technetium Tc99m Generator) and has more than 600 employees worldwide with headquarters in North Billerica, Massachusetts North Billerica is a village (or section) of the Town of Billerica, Massachusetts, one of nine villages (sections) that make up the Town of Billerica. It is the home to Faulkner and Talbot mills and the North Billerica Train Depot. , and offices in Puerto Rico, Canada, and Australia. For more information, visit www.lantheus.com.
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Date:Jun 14, 2009
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