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SciClone Sponsors ZADAXIN Symposium at International Conference for the Study of the Liver; Panel of Experts Discuss ZADAXIN as a Treatment for Hepatitis C and B.


Business Editors/Health/Medical Writers

BIOWIRE2K

SAN MATEO, Calif.--(BUSINESS WIRE)--July 3, 2003

SciClone Pharmaceuticals, Inc. (Nasdaq:SCLN) announced that it is sponsoring a satellite symposium today at the European Association for the Study of the Liver (EASL) in Geneva Geneva, canton and city, Switzerland
Geneva (jənē`və), Fr. Genève, canton (1990 pop. 373,019), 109 sq mi (282 sq km), SW Switzerland, surrounding the southwest tip of the Lake of Geneva.
, Switzerland. At the symposium, internationally renowned experts in immunology and liver disease plan to discuss ZADAXIN (thymalfasin) as a treatment for hepatitis C and hepatitis B. The symposium will include the following speakers and topics:

Adrian Di Bisceglie, M.D. (Moderator)

Chief of Hepatology

Saint Louis University Saint Louis University, mainly at St. Louis, Mo.; Jesuit; coeducational; opened 1818 as an academy, became a college 1820, chartered as a university 1832. Parks College (est. 1927 as Parks College of Aeronautical Technology) in Cahokia, Ill. , St. Louis, Missouri

Medical Director, American Liver Foundation The American Liver Foundation (ALF) is a non-profit organization that promotes liver health and disease prevention. ALF provides research, education and advocacy for those affected by hepatitis and other liver diseases. The ALF has 26 chapters across the U.S. , New York

HCV HCV
abbr.
hepatitis C virus


HCV 1 Hepatitis C virus, see there 2. Human coronavirus. See Coronavirus.
 RNA RNA: see nucleic acid.
RNA
 in full ribonucleic acid

One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic
 and Immunological Responses to Thymalfasin in Combination with Pegylated Interferon Alfa-2A in HCV Non-Responders: A 12-Week Kinetic Study

Dr. Di Bisceglie will discuss the results of a previously reported study which demonstrated that ZADAXIN in combination with pegylated interferon alpha Pegylated interferon alpha can refer to:
  • Pegylated interferon-alpha-2a
  • Pegylated interferon-alpha-2b
 produced 12-week early virologic response (EVR) rates of up to 36% in hepatitis C patients who had failed prior therapy. Recent clinical studies have shown that EVR is an early indicator of sustained response rates. Non-responders seldom have a sustained response to re-treatment with currently approved therapies.

Robert Gish, M.D.

Medical Director

Liver Transplant Program

California Pacific Medical Center California Pacific Medical Center (CPMC) is one of the largest private, not-for-profit, academic medical centers in Northern California. The Medical Center is a combination of three of San Francisco's oldest medical institutions: Pacific Presbyterian Hospital, Children's Hospital , San Francisco, California “San Francisco” redirects here. For other uses, see San Francisco (disambiguation).

The City and County of San Francisco (EN IPA: [sænfrənˈsɪskoʊ] 
 

Case Studies in Hepatitis C Non-Responders

Dr. Gish will discuss case studies of hepatitis C patients who had failed prior therapy and responded to re-treatment with combination therapy that included ZADAXIN.

Hakan Yuceyar, M.D.

Professor of Gastroenterology

Celal Bayar University Medical School

Department of Gastroenterology, Manisa, Turkey

Long-Term Efficacy of Thymosin Thymosin

A polypeptide hormone synthesized and secreted by the endodermally derived reticular cells of the thymus gland. Thymosin exerts its actions in several loci: (1) in the thymus gland, either on precursor stem cells derived from fetal liver or from bone
 Combination Therapy in Precore Mutant Patients

Dr. Yuceyar will discuss results of a previously reported study showing a 71% long-term sustained response rate with combination therapy that included ZADAXIN for difficult to treat hepatitis B patients infected with the precore mutant hepatitis B virus. This sustained response rate compared favorably to 20% of patients using interferon alpha in combination with lamivudine and 10% of patients using interferon alpha alone.

Guido Rasi, M.D.

Head Lab. Cellular Immunology, and Immunotherapy

Institute of Neurobiology Neurobiology

Study of the development and function of the nervous system, with emphasis on how nerve cells generate and control behavior. The major goal of neurobiology is to explain at the molecular level how nerve cells differentiate and develop their
 and Molecular Medicine

National Council for Research, Rome, Italy

Introduction to Thymalfasin, Immunomodulatory Therapy for Liver Disease

Dr. Rasi will discuss ZADAXIN's dual mechanism of action, which provides both immune system enhancing and direct antiviral effects in fighting diseases such as hepatitis C, hepatitis B, and certain cancers.

About SciClone

SciClone Pharmaceuticals is a biopharmaceutical company engaged in the development of therapeutics to treat life-threatening diseases. Its lead product ZADAXIN is in several late-stage clinical trials, including two phase 3 hepatitis C clinical trials in the U.S., a recently completed phase 3 hepatitis B clinical trial in Japan, a phase 2 malignant melanoma clinical trial in Europe, and two phase 2 liver cancer trials in the U.S. In addition to ZADAXIN, SciClone's drug development opportunities include SCV-07, a potentially orally available therapy to treat viral and infectious diseases, and products to address the protein-based disorder that causes cystic fibrosis. Additional information is available at www.sciclone.com.

This press release contains forward-looking statements including statements regarding the potential of ZADAXIN. Clinical and experimental data is not necessarily predictive of the efficacy and safety of ZADAXIN.
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Publication:Business Wire
Geographic Code:1USA
Date:Jul 3, 2003
Words:524
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