Schaeffer's S&P 500 Index Hot Stocks Features Millipore, Serologicals, E. W. Scripps, Yum! Brands, and Coach.

CINCINNATI -- Among the stocks featured in the April 25 edition of Schaeffer's S&P 500 Index Hot Stocks are Millipore (NYSE:MIL), Serologicals (NASDAQ:SERO), E. W. Scripps (NYSE:SSP), Yum! Brands (NYSE:YUM), and Coach (NYSE:COH). Schaeffer's S&P 500 Index Hot Stocks is just one of the many free market commentaries written everyday at www.SchaeffersResearch.com - the home of Bernie Schaeffer and Schaeffer's Investment Research. For additional information about this report or to have it delivered to you free via email every day click on the following link. http://www.schaeffersresearch.com/redirect.aspx?CODE=PRSHS12M&PAGE=1 .

Schaeffer's S&P 500 Index Hot Stocks for Tuesday, April 25, 2006:

A daily feature available on SchaeffersResearch.com is the "SPX Hot Stocks" column. Each afternoon, we will provide a list of the day's top-20 performing stocks in the S&P 500 Index (SPX - 1,301.60) as well as the bottom-20 names. Featured along with this table will be news that is moving some of the securities.

NOTE: Stocks trading under $5 per share have been eliminated from this listing of the top-20 and bottom-20 performing stocks.

The SPX has dipped to the triple support of the 1,300 level, its 10-day moving average and its 20-day moving average, suggesting that a breach of 1,300 this week might open the door for the bears. Currently, 31 percent of the SPX members are in positive territory.

The hottest stock on the SPX is Millipore (NYSE:MIL), which revealed today that it plans to buy Serologicals (NASDAQ:SERO) in a deal worth $1.4 billion. MIL also reported first-quarter earnings of $34.5 million, or 64 cents per share. According to a press release, MIL is a leading bioprocess and bioscience products and services company. Meanwhile, SERO is a global leader in developing and commercializing consumable biological products, enabling technologies and services in support of biological research, drug discovery and bioprocessing. In addition, SERO is the world's leading provider of monoclonal antibodies for the blood typing industry.

Yesterday, I reported that newspaper publisher and broadcaster E. W. Scripps (NYSE:SSP) was near the top of the winner's list on the SPX after Goldman Sachs suggested four near-term catalysts for success: "strong first-quarter earnings tomorrow, improving cable network momentum, the elimination of Shop-at-home losses, and Street recognition of the lowered valuation premium." Today the stock made it to our hotlist again after the company reported first-quarter results. SSP reported that income from continuing operations was $81.5 million, or 49 cents per share, compared with $72.9 million, or 44 cents per share, a year ago. Stock option expense reduced income for the period by three cents per share. Sales for the quarter rose by 22 percent to $590 million. Analysts, on average, expected the company to post a profit of 40 cents per share on revenue of $686.2 million, according to Thomson First Call. Second-quarter earnings from continuing operations are expected to be 58 cents to 62 cents per share, including dilution from the acquisitions of Shopzilla and uSwitch.

Yum! Brands (NYSE:YUM) saw some brokerage action today. CIBC Worlds Markets moved the stock to "outperformer" from "sector performer" and shifted its 12-month price target to $55 from $50. Meanwhile, Piper Jaffray moved it to "outperform" from "peer perform." Prudential took a different view, reiterating YUM at "neutral." When we grabbed our figures, the stock was up more than 3.8 percent.

Turning to the stocks that have fallen on the day, Coach (NYSE:COH) dropped this morning after posting a 35-percent increase in the third-quarter, which, alas, fell short of analysts' expectations. Net earnings were $108.8 million, or 28 cents per share, up from $80.9 million, or 21 cents, a year ago. Quarterly sales came in at $497.9 million, up from the prior year's $415.9 million. COH also increased its full-year forecast and now sees earnings of $1.25 per share.

Click the following link to see a Chart of the SPX 500 Index's Top-20 Percentage Gainers: http://www.schaeffersresearch.com/wire?ID=15868 .

Click the following link to see a Chart of the SPX 500 Index's Top-20 Percentage Losers: http://www.schaeffersresearch.com/wire?ID=15868 .

Take advantage of the timely Schaeffer commentaries by signing up for their free e-newsletters -- Opening View, Market Recap and Monday Morning Outlook. Click here to have the Schaeffer's commentaries delivered to you free via email every day. http://www.schaeffersresearch.com/redirect.aspx?CODE=PRSHS12M&PAGE=1 .

About Schaeffer's Investment Research (www.SchaeffersResearch.com)

Schaeffer's Investment Research, founded by Bernie Schaeffer in 1981, is a financial information and trading resources company. It publishes Bernie Schaeffer's Option Advisor, the nation's leading options subscription newsletter. The firm's contrarian approach focuses on stocks with technical and fundamental trends that run counter to investor expectations. The firm's website, http://www.SchaeffersResearch.com , is recognized as one of the leading information sources for stock and options traders and was cited as the top options website by both Forbes and Barron's. Click here for more details about Schaeffer's trading methodology: http://www.SchaeffersResearch.com/method .