SRI International to Conduct Preclinical Studies of Cancer Drug for Taiwan Liposome Company.MENLO PARK Menlo Park. 1 Residential city (1990 pop. 28,040), San Mateo co., W Calif.; inc. 1874. Electronic equipment and aerospace products are manufactured in the city. Menlo College and a Stanford Univ. research institute are there. 2 Uninc. , Calif. -- SRI International (company) SRI International - One of the world's largest contract research firms. Founded in 1946 in conjuction with Stanford University as the Stanford Research Institute, they later became fully independent and were incorporated as a non-profit organisation under U.S. , an independent nonprofit research and development organization, today announced it has signed an agreement with Taiwan Liposome liposome (lī`pəsōm', lĭp`ə–), microscopic, fluid-filled pouch whose walls are made of layers of phospholipids identical to the phospholipids that make up cell membranes. Company (TLC TLC total lung capacity; thin-layer chromatography. TLC abbr. 1. thin-layer chromatography 2. ), a biopharmaceutical company, to begin preclinical safety and toxicology studies of a new cancer drug developed by TLC. The studies will be conducted in support of an Investigational New Drug (IND) application to the U.S. Food and Drug Administration (FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. ). TLC specializes in the treatment of cancer, ophthalmic conditions and infectious diseases infectious diseases: see communicable diseases. . The agreement with SRI involves the preclinical testing of TLC-1988, a proprietary cancer drug being developed for both chemotherapy and radiotherapy. TLC-1988 is a second-generation camptothecin analog with an efficacy and safety profile that is better than previous drugs in this class. Camptothecin is a quinoline-based alkaloid found in the bark of Chinese camptotheca trees. Preclinical safety studies are necessary to generate sufficient data for IND submission leading to future clinical trials. Under the terms of the agreement, SRI will design and conduct safety and toxicology studies to help determine an appropriate treatment regimen (dose, route and frequency of drug administration) for clinical trials. Following these studies, an interdisciplinary SRI team will manage the filing of the IND. About TLC Founded in 1997 in Taipei, Taiwan, TLC (www.tlcbio.com) is a biopharmaceutical company engaging in research, development and commercialization of proprietary drug delivery system for improving the treatment of cancer, ophthalmic conditions, and infectious diseases. TLC has a team of researchers, management, production experts, and advisors who are building TLC into an organization recognized for its excellence in targeted delivery and rapid advancement of products through the drug development process in Taipei and South San Francisco, California South San Francisco is a city in San Mateo County, California, United States, located on the San Francisco Peninsula in the San Francisco Bay Area. The population was 60,552 at the 2000 census. . TLC was recently chosen among the top 100 hottest startup companies in Asia by Red Herring Red Herring A preliminary registration statement that must be filed with the SEC describing a new issue of stock (IPO) and the prospects of the issuing company. Notes: . About SRI's Biosciences Division The SRI Biosciences Division is a unique organization of approximately 200 people, with all of the resources necessary to take chemical and biological research programs from "idea to IND"[TM] - from initial discoveries to investigational new drug applications to start human clinical trials. The Biosciences Division performs basic research on disease mechanisms like an academic institution; drug discovery and the development of biologics like a biotechnology or pharmaceutical company; and full-service preclinical contract research and development like a CRO (contract research organization). To date, SRI has developed nine drugs internally that have entered clinical trials, with several more currently undergoing preclinical evaluation. Marketed examples of these drugs include bexarotene and halofantrine. Additionally, working with government and industry partners, SRI has helped advance more than 100 drugs into clinical trials, and more than 30 drugs onto the market. Through collaborations with other divisions at SRI, Biosciences is also working at the interfaces of science to create technical platforms for the next generation of drug discovery and development in areas such as drug delivery, diagnostics, medical devices, and systems biology Systems biology, a field of study in the biosciences, focuses on the systematic study of complex interactions in biological systems. Particularly from 2000 onwards, the term is used widely in the biosciences, and in a variety of contexts. . About SRI International Silicon Valley-based SRI International (www.sri.com) is one of the world's leading independent research and technology development organizations. Founded as Stanford Research Institute Stanford Research Institute - Former name of SRI International. in 1946, SRI has been meeting the strategic needs of clients for 60 years. The nonprofit research institute performs client-sponsored research and development for government agencies, commercial businesses, and private foundations. In addition to conducting contract R&D, SRI licenses its technologies, forms strategic partnerships, and creates spin-off companies. |
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