SRI International's Pathway Logic Tools Model Cellular Networks for Breast Cancer Research.MENLO PARK Menlo Park. 1 Residential city (1990 pop. 28,040), San Mateo co., W Calif.; inc. 1874. Electronic equipment and aerospace products are manufactured in the city. Menlo College and a Stanford Univ. research institute are there. 2 Uninc. , Calif. -- SRI's Systems-Based Pathway Logic Software Helps Predict Response to Cancer Therapies SRI International (company) SRI International - One of the world's largest contract research firms. Founded in 1946 in conjuction with Stanford University as the Stanford Research Institute, they later became fully independent and were incorporated as a non-profit organisation under U.S. , an independent nonprofit research and development organization, today announced a grant from the National Cancer Institute (a unit of the National Institutes of Health) and the Lawrence Berkeley National Laboratory Lawrence Berkeley National Laboratory and Lawrence Livermore National Laboratory, scientific research centers run by the Univ. of California, located in Berkeley, Calif., and Livermore, Calif., respectively. (LBNL LBNL Lawrence Berkeley National Laboratory (Berkeley, CA) LBNL Last But Not Least ) for the study of signaling systems in biological networks associated with cancer cell lines. SRI will be a subcontractor to LBNL and will develop a model of cellular signaling networks related to human breast cancer. For this project, SRI will apply Pathway Logic(TM) software, SRI's approach to modeling biological entities and processes based on the Maude computer language (http://maude.csl.sri.com). Pathway Logic(TM) software, founded on the computational science | Computational science (or scientific computing) is the field of study concerned with constructing mathematical models and numerical solution techniques and using computers to analyze and solve scientific, social scientific and engineering problems. of formal methods, allows a rich set of logical operators to define relationships among the components of complex biological systems. A system modeled by Pathway Logic(TM) software offers compelling advantages for understanding biological processes such as signal transduction Signal transduction The transmission of molecular signals from a cell's exterior to its interior. Molecular signals are transmitted between cells by the secretion of hormones and other chemical factors, which are then picked up by different cells. and metabolism at a global level. Such model structures provide a way to organize diverse information concerning biological and biochemical states and processes, creating models that show how the systems evolve from a starting state. The structure of a model can be altered on demand according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. user-specified conditions, and is easily modified to accommodate new information and respond to queries. Potential biological mechanisms, such as susceptibility or resistance to therapeutic intervention, can be experimentally tested using hypotheses created by a model or by querying the model itself. "Pathway Logic software, the core of the 'system' that will be used for this important project, is a computational approach designed to automatically generate and display complex networks of components such as biological molecules and their interactions," said Keith Laderoute, Ph.D., director of SRI's Cancer Biology Program. "Pathway Logic software permits researchers to pose logical questions about large biological networks -- which are actually formal models derived entirely from experimental findings. The broad expertise of SRI's interdisciplinary research team -- coupled with SRI's powerful Pathway Logic tools for studying biological and biochemical change -- can greatly aid in understanding human disease processes such as cancer development." SRI's Biosciences Division and Computer Science Laboratory will co-develop the Pathway Logic model of cellular networks. About SRI International's Biosciences Division SRI's Biosciences Division (http://www.sri.com/biosciences/indexN.html) works with government agencies and commercial pharmaceutical/biotech companies to provide a broad range of preclinical drug discovery and development services, including medicinal chemistry, custom synthesis, regulatory support, efficacy and safety evaluations, pharmacokinetics and metabolism studies, analytical chemistry and formulation design in production in GLP See gateway location protocol. and cGMP environments. The division specializes in cancer, infectious disease Infectious disease A pathological condition spread among biological species. Infectious diseases, although varied in their effects, are always associated with viruses, bacteria, fungi, protozoa, multicellular parasites and aberrant proteins known as prions. and neurobiological neu·ro·bi·ol·o·gy n. The biological study of the nervous system or any part of it. neu  ro·bi research. About SRI International Computer Science Laboratory The Computer Science Laboratory http://www.csl.sri.com in SRI's Information and Computing Sciences Division studies the logical foundation of scalable systems that are beyond the scope of traditional testing or simulation, and builds and applies efficient high-level tools for rigorous mechanical analysis. Current systems of interest include not only traditional computer hardware and software, but also biological systems and nanoelectronics. About SRI International Silicon Valley-based SRI International (http://www.sri.com) is one of the world's leading independent research and technology development organizations. Founded as Stanford Research Institute Stanford Research Institute - Former name of SRI International. in 1946, SRI has been meeting the strategic needs of clients for almost 60 years. The nonprofit research institute performs contract research and development for government agencies, commercial businesses and nonprofit foundations. In addition to conducting contract R&D, SRI licenses its technologies, forms strategic partnerships and creates spin-off companies. |
|
||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion