SPSS Science Introduces New Free Ligand Binding Module.Business Editors/High-Tech Writers CHICAGO--(BUSINESS WIRE)--Aug. 9 2001 Pharmacologists save time and automate analysis by downloading SigmaPlot module Further advancing drug discovery research, SPSS A statistical package from SPSS, Inc., Chicago (www.spss.com) that runs on PCs, most mainframes and minis and is used extensively in marketing research. It provides over 50 statistical processes, including regression analysis, correlation and analysis of variance. Science introduces a new Ligand ligand (lĭg`ənd), charged or uncharged molecule with one or more unshared pairs of electrons that can attach to a central metallic atom or ion to form an aggregate known as a complex ion (see chemical bond). Binding add-on module for SigmaPlot. The Ligand Binding module includes customized analytics and graphics tailored to the study of ligand binding and dose response studies - in which scientists study the binding mechanism between potential drug molecules and target sites such as a receptor site on a cell, a transporter or an enzyme. The module expands the solutions SigmaPlot provides to the pharmaceutical industry by offering pharmacologists a streamlined way of validating biological reaction mechanisms. The Ligand Binding module is available as a download from the SPSS Science Web site at www.spssscience.com. "This module is just one of the steps we are taking to integrate SigmaPlot into the way our customers work," said Ken Kirsten, product manager at SPSS Science. "SigmaPlot's powerful automation and macro creation cababilities simplify processes that involve many replicated steps. As a result, pharmacologists and scientists in a variety of industries can work with our technical consulting team to customize dialog boxes A movable window that is displayed on screen in response to the user selecting a menu option. It provides the current status and available options for a particular feature in the program. and analytical and graphical routines that meet their needs in specialized applications. By automating the data collection, analysis, graphing and report generation, we can help increase efficiency for a variety of scientific workflow processes." A ligand, often a radioactive ligand, is a chemical molecule. Potentially a viable drug candidate, a ligand can bind to a receptor, transporter or other target site. Researchers collect and analyze data in order to understand how the reaction binding mechanism works. SigmaPlot's Ligand Binding module helps scientists who collect data on several drugs or molecules simultaneously and need to fit their data to mathematical models
Benefits of the Ligand Binding module include: - Analyze and plot ligand/receptor and dose response data quickly and easily -- Automatically fit radioligand and dose response equations for multiple compounds with replicate data. Select the type of study in the customized dialog and specify the number of replicate values to validate assumptions of the reaction mechanism. - Select from a wide range of models to determine parameter values -- Choose from ten built-in equations, create a new equation or modify an existing equation to analyze the number of binding sites and their affinity for various drugs. Fit one and two-site saturation equations to determine the number of binding sites, Bmax, and the ligand affinity, Kd. Fit competition and sigmoidal dose-response equations to learn the affinity of the receptor for the competing molecule, EC50, or specify ligand concentration and Kd to generate Ki, the equilibrium dissociation constant. Automatically generate a report with the equation fit results and the associated error analysis. - Save time by plotting multiple compounds simultaneously -- Automatically generate a plot of mean response versus concentration and include the best-fit lines for each compound. Users can specify the minimum and maximum x values and fit range to customize analysis as well as modify their graph to present results exactly the way they want. About SigmaPlot SigmaPlot is SPSS' award-winning scientific graphing software which makes it easier for users to present their findings accurately using precise, publication-quality graphs, data analysis and presentation tools. SigmaPlot offers numerous scientific options such as automatic error bars, regression lines Noun 1. regression line - a smooth curve fitted to the set of paired data in regression analysis; for linear regression the curve is a straight line regression curve , confidence intervals confidence interval, n a statistical device used to determine the range within which an acceptable datum would fall. Confidence intervals are usually expressed in percentages, typically 95% or 99%. , axis breaks, technical axis scales, non-linear curve fitting Curve fitting is finding a curve which matches a series of data points and possibly other constraints. This section is an introduction to both interpolation (where an exact fit to constraints is expected) and regression analysis. Both are sometimes used for extrapolation. and a data worksheet for powerful data handling. Add-ons such as the Enzyme Kinetics Enzyme kinetics is the study of the rates of chemical reactions that are catalysed by enzymes. The study of an enzyme's kinetics provides insights into the catalytic mechanism of this enzyme, its role in metabolism, how its activity is controlled in the cell and how drugs and , Electrophysiology electrophysiology /elec·tro·phys·i·ol·o·gy/ (-fiz?e-ol´ah-je) 1. the study of the mechanisms of production of electrical phenomena, particularly in the nervous system, and their consequences in the living organism. 2. and Ligand Binding modules provide custom capabilities for specific research applications. More than 100,000 research professionals use SigmaPlot, making it the technical graphing software standard. SigmaPlot is used in a wide range of fields including medical research, life sciences, chemistry, engineering, environmental science and physics. It has won several awards including Scientific Computing and Instrumentation Reader's Choice Award, NASA Tech Briefs NASA Tech Briefs is a magazine published by the National Aeronautics and Space Agency of the United States. This magazine is available, in either print form or electronically as PDF files, for free. Product of the Month and Computers in Physics Product of the Month. Additional information is available at www.spssscience.com or by calling 800-543-2185. About SPSS Science SPSS Science, an operating unit operating unit A type of operating company that engages in transactions with outsiders and that is owned by another business. For example, in 1995 the stockholders of Capital Cities/ABC approved a $19 billion merger with the Walt Disney Company, whereupon of SPSS Inc., provides award-winning software designed for technical professionals. In addition to the capabilities offered by SigmaPlot, users can develop more meaningful conclusions and present compelling results with SPSS' statistical, graphing, curve fitting, image analysis, peak separation and fitting and gel electrophoresis gel electrophoresis n. Electrophoresis performed in a gel composed of agarose, polyacrylamide, or starch. packages. About SPSS Inc. SPSS Inc., (Nasdaq: SPSS) headquartered in Chicago, IL, USA, is a worldwide provider of analytical technology for business, government, and higher education higher education Study beyond the level of secondary education. Institutions of higher education include not only colleges and universities but also professional schools in such fields as law, theology, medicine, business, music, and art. . The company's solutions and products enable customers to make better decisions by learning from the past, understanding the present and anticipating the future. With this insight, organizations gain a true competitive advantage: the ability to manage the future. SPSS analytical technology is brought to the market through five divisions: CustomerCentric Solutions (for integrated analytical CRM (business) analytical CRM - Software which helps a business build customer relationships and analyse ways to improve them. solutions); SPSS BI (for data mining and statistical products and services used to solve business problems); ShowCase (for analytical products operating on IBM (International Business Machines Corporation, Armonk, NY, www.ibm.com) The world's largest computer company. IBM's product lines include the S/390 mainframes (zSeries), AS/400 midrange business systems (iSeries), RS/6000 workstations and servers (pSeries), Intel-based servers (xSeries) iSeries/AS400 platform); SPSS MR (for analytical solutions in the market research industry); and SPSS Enabling Technologies (for integration of SPSS technologies in third party solutions through strategic partnerships). For more information, visit www.spss.com http://www.spss.com/. SPSS information is available on the World Wide Web through the SPSS Press Center at: http://www.spss.com/press |
|
||||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion