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Rotational bed therapy to prevent and treat respiratory complications: a review and meta-analysis.

* BACKGROUND Immobility is associated with complications involving many body systems.

* OBJECTIVE To review the effect of rotational therapy (use of therapeutic surfaces that turn on their longitudinal axes) on prevention and/or treatment of respiratory complications in critically ill patients.

* METHODS Published articles evaluating prophylaxis and/or treatment were reviewed. Prospective randomized controlled trials' were assessed for quality and included in meta-analyses.

* RESULTS A literature search yielded 15 nonrandomized, uncontrolled, or retrospective studies. Twenty prospective randomized controlled trials on rotational therapy were published between 1987 and 2004. Various types of beds were studied, but few details on the rotational parameters were reported. The usual control was manual turning of patients by nurses every 2 hours. One animal investigation and 12 clinical trials addressed the effectiveness of rotational therapy in preventing respiratory complications. Significant benefits were reported in the animal study and 4 of the trials. Significant benefits to patients were reported in 2 of another 4 studies focused on treatment of established complications. Researchers have examined the effects of rotational therapy on mucus transport, intrapulmonary shunt, hemodynamic effects, urine output, and intracranial pressure. Little convincing evidence is available, however, on the most effective rotation parameters (eg, degree, pause time, and amount of time per day). Meta-analysis suggests that rotational therapy decreases the incidence of pneumonia but has no effect on duration of mechanical ventilation, number of days in intensive care, or hospital mortality.

* CONCLUSIONS Rotational therapy may be useful for preventing and treating respiratory complications in selected critically ill patients receiving mechanical ventilation. (American Journal of Critical Care. 2007;16:50-62)


The use of positioning therapy has been advocated for the management of respiratory conditions in critically ill patients. (1-4) This review is focused on a method of positioning patients that uses a programmable bed that turns on its longitudinal axes, intermittently or continuously, with the aim of preventing and/or treating respiratory complications in critically ill patients. The generic term commonly used for this therapy is continuous lateral rotation. If the degree of turn is 40[degrees] or greater to one side (80[degrees] total arc), the treatment may be referred to as Kinetic Therapy. Kinetic Therapy is a trademarked term and has been supported by the Centers for Disease Control and Prevention as a measurable method of turning patients. The terms continuous lateral rotation and Kinetic Therapy are often loosely used in a similar context. The rotation of the patient on a bed is hypothesized to improve drainage of secretions within the lung and lower airways, to increase functional residual capacity by providing an increased critical opening pressure to the independent lung, and to reduce the risk of venous thrombosis and associated pulmonary embolism. (5)

It has long been recognized that immobility is associated with complications involving many body systems (6-13) (Table 1). Rotational therapy may be effective in treating and preventing many of these complications; however, this review is limited to a discussion of the role of rotational therapy with respect to respiratory complications.

Respiratory complications experienced by patients in an intensive care unit (ICU) include ventilator-associated pneumonia (VAP), atelectasis, and acute respiratory distress syndrome (ARDS). Patients with VAP may spend longer in the ICU and have a higher mortality rate than patients without VAP. (14) Guidelines for the prevention of pneumonia advocate a range of interventions that may be organizational, pharmacological, or physical. (15-17) ARDS is associated with high morbidity and mortality. (18) Current best practice is focused on ventilatory strategies to protect the lung. (19) Rotation of patients on therapeutic beds is one of the interventions that may be useful in preventing and treating these respiratory complications.

Description of Beds

Use of special beds to turn critically ill patients has been a recognized intervention for many years. A study (20) describing the RotoRest bed was published in 1967. Other early examples include the CircOlectric bed, which could even turn a patient prone. Both beds were used as methods of mobilization for patients with spinal cord injuries, but rotation was often limited by those patients' lack of vascular tone and compensatory response to gravitational shifts. (21)

Several manufacturers market a variety of therapeutic surfaces that are based either on a rotating rigid platform or an air-filled mattress. These beds vary in the degree and frequency of rotation, the method of rotation, and the inclusion of other therapies such as low air loss, pulsation, percussion, and vibration (Table 2). The RotoRest bed is based on a rigid platform and is indicated for patients with spinal injuries for which alignment must be maintained. For other patients, the RotoRest bed may prove to be cumbersome, and it may be uncomfortable for patients who are conscious. Air-filled mattresses were developed primarily for the prevention of pressure ulcers but now have been modified to provide automated turning.

In 2001, in an observational study (22) of clinical practice during a single day in Canadian ICUs, researchers found that 3.1% of patients were on a rotational bed.


A literature search was conducted by using the PubMed database for articles published between 1966 and 2004. Relevant search terms included patient position, rotational and kinetic therapy, therapeutic bed and/or mattress, and the names of specific beds. Several manufacturers were contacted and invited to supply references. Reference lists of papers were scrutinized for details of other relevant publications.

All reports of studies in which rotational therapy was used to treat and/or prevent respiratory complications were reviewed. From among these articles we selected those that reported a prospective randomized study. Data on severity of illness and basic information about patients, interventions, and outcomes evaluated in the studies or reviews were extracted. Quality was assessed by using guidelines published by the Scottish Intercollegiate Guidelines Network ( A meta-analysis was performed on articles that fulfilled basic quality standards for which sufficient outcome data were available. Review Manager software (RevMan Version 4.2 for Windows; The Nordic Cochrane Centre, Copenhagen, Denmark) was used for these meta-analyses.


Routine nursing management of ICU patients usually includes regular repositioning. Turning of the patient every 2 hours has long been an established standard of care. (23) Manual turning every 2 hours for 24 hours after cardiac surgery resulted in a significant decrease in the incidence of postoperative fever and a 32% reduction in the duration of a patient's stay in a surgical ICU. (24) Schallom et a1 (25) reported hourly observations of the positions of 284 critically ill tube-fed patients for 3 days between 8 AM and midnight. Patients in whom pneumonia developed were turned significantly less often (mean 8.7 turns) than were patients in whom pneumonia did not develop (mean 10.6 turns).

Nonrandomized, Uncontrolled, or Retrospective Studies

These studies include medical ICU patients, (26) a mix of critically ill patients, (27) and patients with spinal cord injuries (28-30) and trauma. (31-33) Results of some of these studies suggest that rotational therapy prevents respiratory complications (28-32) or is useful in their treatment. (26,31,33,34) In a retrospective study, Takiguchi et a1 (27) compared 2 types of bed, the Restcue (Support Systems International, Inc, Charleston, SC) and the Biodyne (Kinetic Concepts, Inc [KCI], San Antonio, Tex), and 2 different protocols, one aimed at preventing respiratory complications (with the Restcue) and the other targeted at treating patients with established complications (with the Biodyne). Both beds are based on air-inflated rotational mattresses, though the beds differ in their design and the mechanics of rotation. The preventive strategy was significantly more successful than was the strategy aimed at treating patients with established complications.


Sahn (35) reviewed the results of 4 prospective randomized studies (36-39) and 2 retrospective analyses. (28,29) Sahn tentatively concluded that the early use of rotational therapy in comatose or immobile patients decreased the incidence of infection of the lower respiratory tract, including pneumonia, during the first 7 to 14 days of intensive care. In that article, (35) Sahn suggested that a large randomized prospective trial was necessary. Choi and Nelson (40) performed a meta-analysis on the studies (36-39) reviewed by Sahn and 2 unpublished presentations, one by Narayan et al (41) and the other by Nelson. (42) Nelson and Choi (43) later published an article that appears to present the results of that meta-analysis. All the studies looked at critically ill adult patients randomized to the RotoRest or to conventional surfaces with manual turning by nursing staff. The analysis showed that the incidence of pneumonia, atelectasis, number of hours intubated, and length of ICU stay were significantly reduced in the treatment group. No significant difference was found in other outcomes, including hospital stay and mortality. Reviews published in 1993 (44) and 1994 (45) summarized the same 4 main studies. (36-39)

The Centers for Disease Control and Prevention (CDC) and the Healthcare Infection Control Practices Advisory Committee have published guidelines for the prevention of healthcare-associated pneumonia. (15) Referencing one review (46) and 6 articles about rotational beds, (37-39,47-49) the guidelines describe the use of rotating beds as an "unresolved issue." The conclusion was that "no recommendation can be made for the routine use of turning or rotational therapy, either by 'kinetic' therapy or by continuous lateral rotational therapy for prevention of health-care-associated pneumonia in critically ill and immobilized patients."

In an excellent article on the prevention of VAR Dodek et al (17) reviewed the strategies of having the patient semirecumbent, positioning the patient prone, and using rotational bed therapy. A treatment was recommended "if there were no reservations about endorsing an intervention" and should be considered "if the evidence supported an intervention but there were minor uncertainties about the benefits, harms or costs." It was concluded that no recommendation could be made for the prone position and that the semirecumbent position, with a goal of 45[degrees], should be recommended in patients without contraindications. The evidence on rotational bed therapy was from 7 level 2 trials (37-39,47,49-51) and a level 3 trial. (48) The conclusion was that "clinicians [should] consider the use of kinetic beds."

Prospective Randomized Controlled Trials

A literature search for the years 1987 through 2004 yielded 20 reports (36-39,43,47-61) of prospective randomized controlled trials in which treatment on a turning bed was compared with a control. A variety of beds were used, most commonly the RotoRest. Details are sparse on the intended or achieved therapeutic parameters such as degree of rotation, number of rotations per hour, and duration of rotation. None of the studies showed any statistically significant differences in mortality between patients treated with rotation and control subjects.

One study (55) was in neonates who were receiving mechanical ventilator support at 24 hours of age. They all weighed more than 1500 g and were predicted to need at least 24 additional hours of mechanical ventilation. Infants were randomized to a control group, whose members were turned from one side to the other every 12 hours, or a treatment group, whose members were continuously rotated to 40[degrees] on each side every 3.5 minutes on a P-30 Pediatric Kinetic Treatment Table (KCI). The study was started when the infant was 24 hours old and completed after extubation and when supplemental oxygen was no longer required. The only significant difference found was that the treatment group required oxygen for a shorter time than did the control group.

Staudinger et al (60) compared gas exchange and hemodynamics in 26 patients with nontraumatic ARDS who were receiving mechanical ventilation and were either placed prone or continuously rotated. Respiratory measures did not differ significantly between the prone group and the rotated group during the first 72 hours of treatment.

Davis et al (59) used patients as their own controls to assess cardiorespiratory variables and sputum production. The patients had ARDS, were in hemodynamically stable condition, and did not have severe injuries of the head or spine. Patients were randomized to have 4 turning and secretion management regimens in a random sequence during a 24-hour period. These regimens were as follows: (1) manual turning every 2 hours from one lateral side to the other, (2) turning every 2 hours with 15 minutes of manual percussion and postural drainage, (3) continuous rotation of the bed with a 2-minute pause in the lateral position, (4) continuous rotation of the bed with a 2-minute pause in the lateral position and 15 minutes of percussion provided by the bed every 2 hours, 60 to 90 minutes into the every-2-hour turning regimen. The only statistically significant differences were an increased volume of sputum in patients receiving the 2 treatments involving bed rotation (regimens 3 and 4).

The study in baboons undertaken by Anzueto et al (56) provides some of the most objective evidence for the efficacy of rotational therapy. The animals were sedated, paralyzed, and supported via mechanical ventilation for l1 days with a tidal volume of 12 mL/kg. Peak inspiratory pressures at day 11 were 28 cm [H.sub.2]O in controls compared with 20 cm [H.sub.2]O in the treatment group. In addition, although none of the animals receiving rotational therapy showed any abnormalities on radiological images, 6 of the 7 control animals had patchy atelectasis apparent on a chest radiograph. The ratio between Pa[O.sub.2] and the fraction of inspired oxygen ([PaO.sub.2]/[FIO.sub.2]) at day 11 was lower in the controls. The percentage of neutrophils obtained by bronchoalveolar lavage at days 7 and 11 was much higher in the controls. A quantitative measure of consolidation was higher in the controls (11%) than in the animals that were rotated (<0.6%).

This leaves 12 prospective randomized studies (36-39, 43,47-51,53,58) focused on the prevention of respiratory complications and 4 studies (52,54,57,61) focused on the treatment of established complications (Tables 3 and 4). Four of the papers (39,47-49) reported significant benefits to patients in the prevention of respiratory complications. Among the other studies, Demarest et al (50) reported a lower incidence of atelectasis and pneumonia in the subgroup of patients who had normal findings on chest radiographs at the start of the study. Gentilello et al (37) combined atelectasis and pneumonia into a single group called major pulmonary complications and found a lower incidence in the rotational therapy group. Kelley et al (36) found that rotational therapy decreased the incidence of infection, pneumonia, sepsis, and urinary tract infections, and reduced the likelihood of multiple infections. In a large, well-conducted study by MacIntyre et al, (58) the only significant finding was a lower incidence of urinary tract infections (11% vs 27%). Summer et al (38) found that rotational therapy was associated with fewer ventilator days for patients with chronic obstructive airways disease and shortened the ICU stay for patients with sepsis and chronic obstructive airways disease. (38)

Shapiro and Keegan (54) investigated the treatment of respiratory complications in patients with pulmonary contusions. In that study, (54) outcomes did not differ between the control group and the study group. However, the groups were poorly matched because control patients had injuries that were less severe, with a mean injury severity score of 29.0 compared with 45.1 for the treatment group. McLean (52) looked at 35 patients with trauma and a [Pao.sub.2]/[FIO.sub.2] less than 225 mm Hg and an injury severity score greater than 16. In that prospective, prophylactic study, (52) the end point was an increasing impact on lung function, defined as an increased ventilation requirement. McLean concluded that "aggressive rotational therapy has a positive impact on lung function." Reports of 2 other studies (57,61) showed that rotational therapy was beneficial in the treatment of patients with respiratory complications.

The study by Ahrens et al (61) is by far the largest, with 234 subjects, and is the most recent. Because rotational therapy may not be tolerated in conscious patients, only those with a score of less than 11 on the Glasgow Coma Scale were eligible. Thus the results from that study may not be relevant to patients who are sedated and receiving mechanical ventilation. The main respiratory outcomes, VAP and lobar atelectasis, were both significantly less common in the group given rotational therapy. However, no information was provided on the incidence of pneumonia or atelectasis upon entry to the study or when these complications occurred. The control patients received mechanical ventilator support for a mean of 10.1 days and were in the ICU for a mean of 13.6 days. The figures for the intervention group were 10.8 days of mechanical ventilation and 13.5 days in the ICU. Mortality was 42% in both groups.

Meta-analyses were performed when suitable data were available on the incidence of pneumonia, the number of ICU ventilator days (mean and SD), number of days in the ICU (mean and SD), and hospital mortality. Most of the articles did not provide enough details for us to determine whether control groups had regular turning and whether the intentions of the intervention were achieved (Table 4). Because of the nature of the intervention, the studies were not double blinded. Methods of randomization were not always stated, and in some studies patients were randomized to groups by month or order of admission. One study (54) had a mismatch between control and treatment groups; that study was not included in the analysis. Another article (36) provided details on the incidence of pneumonia in the study but did not define the diagnosis; that article was excluded from the pneumonia recta-analysis. The meta-analyses showed no difference between control and intervention groups in days of mechanical ventilation, days in the ICU, or mortality (Figures 1-3). The analysis did suggest a benefit from rotational therapy with respect to the incidence of pneumonia (Figure 4).


Dolovich et al (62) used a radiolabeled aerosol to examine the effect of rotation on mucus transport in 13 patients receiving mechanical ventilation while on Biodyne beds. The intervention consisted of 90 minutes of 30[degrees] rotation to both sides preceded and followed by a control period. Although clearance of mucus may have differed between the left and right lungs, rotation to this angle for this brief period did not affect overall clearance.

In another study (63) of 10 deeply sedated patients with acute lung injury, ventilation-perfusion ratios were measured after 20 minutes of rotational therapy and compared with the ratios that had been obtained with the patient resting supine. Intrapulmonary shunt was significantly decreased and [Pao.sub.2]/[FIO.sub.2] improved during rotational therapy. The improvement in [Pao.sub.2]/[FIO.sub.2] was seen in patients with "mild to moderate" lung injury but not in patients with late or progressive ARDS.

The hemodynamic effects of lateral rotation were investigated in 12 patients with severe respiratory failure who were receiving infusions of inotropic agents. (64) They were positioned supine, left dependent, and right dependent, pausing for 15 minutes in each position. Cardiac index, intrathoracic blood volume, and right ventricular end-diastolic volume increased significantly in the left-dependent position compared with supine. In the right position, arterial pressure and right ventricular end-diastolic volume decreased. Other investigators (65) have failed to find a significant cardiovascular effect associated with steep lateral positioning.

Complications and Other Issues

Complications associated with rotational therapy include disconnection of intravascular catheters, (38) intolerance of patients to the rotation, (38,39,58) adverse effects on intracranial pressure, (36,37) and arrhythmias, (38,66) In a study of 10 patients with head injuries, Gonzalez Arias et al (67) found that rotational therapy did not have any significant effect on intracranial pressure.

Cost Analysis

Few relevant data on the cost of rotational therapy are available. (61,68) Choi and Nelson (40) stated that the charges incurred in the ICU (with kinetic therapy) were no different than the charges for control patients. Ahrens et al (61) found that ICU costs were lower in patients who were on the rotational therapy bed ($81 740) than in patients who were not ($84 958), but this difference was not statistically significant.

Implementing Rotational Therapy

Several examples of guidelines for the use of rotational therapy are available. One set of guidelines suggests that rotation should be 40[degrees] or greater for at least 18 hours a day. (69) Appropriate patients included those with a [Pao.sub.2]/[FIO.sub.2] less than 300 mm Hg, an [FIO.sub.2] greater than 0.5, a positive end-expiratory pressure greater than 10 cm [H.sub.2]O, those at risk for development of ARDS, or those with pneumonia, atelectasis, or infiltrates visible on radiograph Apart from those with spinal cord injury, agitated patients and patients not receiving mechanical ventilation were unsuitable because of their inability to tolerate aggressive rotational therapy.


From a physiological perspective, rotational therapy should have a beneficial effect on the prevention and treatment of respiratory complications in critically ill patients. Authors of several case reports and reports of uncontrolled studies have claimed that positioning therapy has beneficial effects on pulmonary function.

Although a number of randomized prospective controlled trials have been conducted, most of them had significant shortcomings.


The usual control for the randomized studies cited in this review was manual turning of patients every 2 hours. This control may not be reflective of actual practice. In the study by Schallom et al, (25) although 23 turns were possible for each patient, the mean actual number of turns was 9.6. In a study in which 74 ICU patients were observed every 15 minutes for a mean of 7.7 hours, Krishnagopalan et al (70) found that only 2 patients (2.7%) had a change in body position every 2 hours, and 28% of all patients were supine throughout all observation periods.

Little convincing evidence is available about which rotation parameters are the most effective. The effectiveness of rotational therapy may not depend entirely on the angle of rotation, but also on the frequency of rotation, the pause time, and the use of adjuncts such as vibration, percussion, or pulsation. The duration of rotation also may be important, as well as the underlying disease, the size and weight of the patient, and the use of physiotherapy or other respiratory interventions.

Berkemeier et al (71) presented an abstract of a study performed in 19 patients with ARDS who were randomized to 1 of 4 groups. One group was not rotated and the other groups were rotated for 24 hours to a maximum of 20[degrees], 40[degrees], or 60[degrees]. In patients rotated to 60[degrees], cardiac output had increased and intrapulmonary shunt had decreased at 24 hours after baseline (baseline measurements were obtained before rotation). In patients rotated to 40[degrees] or 60[degrees], Pa[O.sub.2] was increased at 24 hours after baseline. However, because no figures were given for FI[O.sub.2], this information could not be meaningfully interpreted. No articles could be found in which these findings were reported completely. A large multicenter trial comparing different degrees of rotation is currently being performed and may provide answers to this question.

Some patients who are awake find it difficult to tolerate continuous rotation, particularly at the higher degrees of rotation. Personal experience suggests that tolerance may be improved by administering a scopolamine patch, providing both antiemetic and sedative effects. In general, acute lateral rotation therapy may be best suited to unconscious or sedated patients. It is possible that selected patients, perhaps those with a high body mass index, will benefit more than others. These patients may be more likely to have respiratory compromise and complications and may be less likely to receive regular manual turning. However, no data are currently available to support this hypothesis one way or another. Little evidence is available to guide clinicians in determining which diseases or complications are most responsive to rotational therapy.

Rotational therapy is just one technique among a raft of other interventions designed to prevent and treat respiratory complications in critically ill patients. Very few of the prospective randomized studies provided information about other treatments the patients were receiving or about steps taken to standardize therapy other than the rotational bed therapy. Unless overall management is standardized, the contribution of rotational bed therapy will remain difficult to assess.

Finally, the beds considered in this review have other uses apart from the prevention and treatment of respiratory complications, such as maintenance of skin integrity and mobilization of secretions. These other uses must be considered when deciding whether to place a compromised patient on a therapeutic bed.


This article would never have been written without Maria Etchels, who provided the inspiration and motivation.


Barbara McLean has been a speaker for KCI, Inc.

Corresponding author: David R. Goldhill, The Royal National Orthopaedic Hospital, Stanmore, Middlesex HA7 4LP, United Kingdom (e-mail:

To purchase reprints, contact The InnoVision Group, 101 Columbia, Aliso Viejo, CA 92656 Phone, (800) 809-2273 or (949) 362-2050 (ext 532); fax, (949) 362-2049; e-mail,

David R. Goldhill, MA, MBBS, MD, FRCA, Michael Imhoff, MD, PhD, Barbara McLean, RN, MN, CCRN, CCNS, and Carl Waldmann, MA, MB, Bchir, FRCA, EDIC. From The Royal National Orthopaedic Hospital, Stanmore, Middlesex, United Kingdom (DRG), Department for Medical Informatics, Biometrics, and Epidemiology, Ruhr-Universitat Bochum, Bochum, Germany (MI), Atlanta Medical Center, Atlanta, Ga (BM), and The Royal Berkshire Hospital, Reading, United Kingdom (CW).


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(57.) Raoof S. Chowdhrey N, Raoof S. et al. Effect of combined kinetic therapy and percussion therapy on the resolution of atelectasis in critically ill patients. Chest. 1999; 115:1658-1666.

(58.) MacIntyre NR, Helms M, Wuoderink R, Schmidt G, Sahn SA. Automated rotational therapy for the prevention of respiratory complications during mechanical ventilation. Respir Care. 1999;44:1447-1451.

(59.) Davis K, Johannigman JA, Campbell RS, et al. The acute effects of body position strategies and respiratory therapy in paralyzed patients with acute lung injury. Crit Care. 2001:5:81-87.

(60.) Staudinger T, Kofler J, Milliner M. et al. Comparison of prone positioning and continuous rotation of patients with adult respiratory distress syndrome: results of a pilot study. Crit Care Med. 2001;29:51-56.

(61.) Ahrens T, Kollef M, Stewart J, Shannon W. Effect of kinetic therapy on pulmonary complications. Am J Crit Care. 2004:13:376-383.

(62.) Dolovich M, Rushbrook J, Churchill E, Mazza M, Powles ACP. Effect of continuous lateral rotational therapy on lung mucus transport in mechanically ventilated patients. J Crit Care. 1998; 13:119-125.

(63.) Bein T, Reber A, Metz C, Jauch KW, Hedenstierna G. Acute effects of continuous rotational therapy on ventilation-perfusion inequality in lung injury. Intensive Care Med. 1998;24:132-137.

(64.) Bein T, Metz C, Keyl C, Pfeifer M, Taeger K. Effects of extreme lateral posture on hemodynamics and plasma atrial natriuretic peptide levels in critically ill patients. Intensive Care Med. 1996;22:651-655.

(65.) Nelson LD, Anderson HB. Physiologic effects of steep positioning in the surgical intensive care unit. Arch Surg. 1989;124:352-355.

(66.) Kollef MH, Witte MC. Pacing wire-induced recurrent ventricular tachycardia secondary to kinetic therapy bed motion. Crit Care Med. 1988;16:651-652.

(67.) Gonzalez-Arias SM, Goldberg ML, Baumgartner R, Hoopes D, Ruben B. Analysis of the effect of kinetic therapy on intracranial pressure in comatose neurosurgical patients. Neurosurgery. 1983:13:654-656.

(68.) Kelley RE, Bell LK, Mason RL. Cost analysis of kinetic therapy in the prevention of complications of stroke. South Med J. 1990;83:433-434.

(69.) Powers J, Daniels D. Turning points: implementing kinetic therapy in the ICU. Nurs Manag (Harrow). May 2004;35(suppl): 1-7.

(70.) Krishnagupalan S, Johnson EW, Low LL, Kaufman LJ. Body positioning of intensive care patients: clinical practice versus standards. Crit Care Med. 2002;30:2588-2592.

(71.) Berkemeier H, Huemer G, Steltzer H, et al. Effects of different degrees of the Roto-Rest Kinetic Treatment Table (RRKTT) on extravascular lung water (EVLW), hemodynamics and oxygenation in patients with ARDS [abstract]. Anesthesiology. 1996;85:A262.
Table 1 Hazards of immobility

System Complication

Respiratory Pneumonia, atelectasis, pulmonary
Cardiovascular Postural hypotension, cardiac muscle
 atrophy, deep vein thrombosis
Skin Pressure ulcers
Renal Calculi, nephritis
Hematological Anemia
Gastrointestinal Constipation and fecal impaction
Metabolic Glucose intolerance, negative nitrogen
Musculoskeletal Osteoporosis, muscle atrophy, contractures
Neurological Depression, psychosis

Table 2 Details of some current rotational therapy beds *

Name Rotation

KCI Triadyne 45[degrees]
KCI RotoRest 62[degrees]
KCI Therapulse 30[degrees]
KCI BariAir 25[degrees]
Hill-Rom 40[degrees]
 Respistar (V/QUE) 40[degrees]-45[degrees]
 Respistar (Effica) 40[degrees]-45[degrees]
 TotalCare Sp[O.sub.2]RT 40[degrees]-45[degrees]
Huntleigh ACER 40[degrees]

Name Percussion pulsation

KCI Triadyne Yes Yes
KCI RotoRest No No
KCI Therapulse No Yes
KCI BariAir Yes Yes
 Respistar (V/QUE) Yes Yes
 Respistar (Effica) Yes Yes
 TotalCare Sp[O.sub.2]RT Yes Yes
Huntleigh ACER No No

* Other characteristics not detailed include the method of achieving
rotation, the timing of the rotation, the capability of the bed to
rest in certain positions and/or assume a chair position, and the
material used for the mattress cover. The beds vary in the safe
maximum weight they will support and whether or not they have
safety features such as interlocking side rails. The details, when
available, are those provided by the companies that manufacture
the beds and have not been independently verified.

Table 3 Summary of randomized prospective studies

Reference Year Type of patients Intervention

Kelley et al (36) 1987 Stroke; drowsy, Prophylaxis
 stuporous, light
Gentilello et al 1988 Trauma Prophylaxis
Summer et al (38) 1989 Medical ICU Prophylaxis
Demarest et al (50) 1989 Trauma unit Prophylaxis
Fink et al (39) 1990 Surgical ICU, Prophylaxis
Clemmer et al (53) 1990 Head injury Prophylaxis

Nelson and Choi 1992 Surgical ICU, trauma Prophylaxis
Shapiro and Keegan 1992 Surgical ICU Treatment
deBoisblanc et al 1993 Medical ICU Prophylaxis
Whiteman et al (49) 1995 Liver transplant ICU Prophylaxis
Traver et al (51) 1995 ICU admission and in Prophylaxis
 study for >48 hours
Raoof et al (57) 1999 Medical ICU or Treatment
 ventilator ward
MacIntyre et al 1999 ICU Prophylaxis
McLean (52) 2001 Trauma (ISS [greater Treatment
 than or equal to]
 16) and Pa[O.sub.2]/
 <225 mmHg
Kirschenbaum et al 2002 Long-term mechanical Prophylaxis
 (48) ventilation
Ahrens et al (61) 2004 Multicenter ICUs Treatment

Reference patients Type of bed

Kelley et al (36) 43 RotoRest (KCI)
Gentilello et al 65 RotoRest (KCI)
Summer et al (38) 83 RotoRest (KCI)
Demarest et al (50) 30 RotoRest (KCI)
Fink et al (39) 99 RotoRest (KCI)
Clemmer et al (53) 49 Kinetic Treatment Table (KCI)
Nelson and Choi 100 RotoRest (KCI)
Shapiro and Keegan 32 RotoRest (KCI)
deBoisblanc et al 124 Biodyne (KCI)
Whiteman et al (49) 69 Restcue Dynamic Air Therapy Bed
 (Support Systems International)
Traver et al (51) 103 Biodyne (KCI)
Raoof et al (57) 24 Triadyne (KCI)
MacIntyre et al 104 Restcue Bed
 (58) (Support Systems International)
McLean (52) 35 Triadyne (KCI)
Kirschenbaum et al 37 Effica (Hill-Rom)
Ahrens et al (61) 234 Triadyne (KCI)

Reference Study entry

Kelley et al (36) Within 24 hours of admission
Gentilello et al Within 24 hours of admission
Summer et al (38) Within 24 hours of ICU admission after consent
 and if bed available
Demarest et al (50) Normal findings on at least 50% of fields on
 chest radiograph
Fink et al (39) Within 24 hours of admission
Clemmer et al (53) 24 to 48 hours of ICU admission
Nelson and Choi Within 16 hours of admission
Shapiro and Keegan Blunt chest trauma and hypoxemic
deBoisblanc et al Within 24 hours of admission
Whiteman et al (49) Mechanical ventilator support if GCS score s11,
 24 hours after admission
Traver et al (51) After 2 days in ICU
Raoof et al (57) Respiratory failure and atelectasis
MacIntyre et al Supported with mechanical ventilation with no
 (58) clinical evidence or findings on chest
 radiograph indicative of respiratory infection
McLean (52) Within 24 hours of injury
Kirschenbaum et al Admitted to ICU
Ahrens et al (61) Pa[O.sub.2]:F[IO.sub.2] <250, GCS score <11,

Reference Rotation or study end

Kelley et al (36) Bed confinement ended
Gentilello et al Out of bed, died or discharged
Summer et al (38) Patient request or extubation
Demarest et al (50) 7 days
Fink et al (39) Discharge from ICU
Clemmer et al (53) Weaned from ventilator and transferred, or
 after 10 days, or death
Nelson and Choi Hospital discharge or death
Shapiro and Keegan Removed from bed because of instability, need
 (54) to increase mobility, or patient's request
deBoisblanc et al 5 days
Whiteman et al (49) Able to be out of bed for 3 days, or unable to
 rotate for >10 hours/day for 3 days, or
 transferred from ICU
Traver et al (51) Out of bed >3 hours day, or transferred to
 different bed, or rotating less than 12
 hours/day or transferred or died
Raoof et al (57) Transfer or up to 2 weeks
MacIntyre et al Development of lower respiratory tract
 (58) inflammatory syndrome (see article for
McLean (52) Not stated
Kirschenbaum et al Discharge from ICU
Ahrens et al (61) Intolerance

Abbreviations: [FIO.sub.2], fraction of inspired oxygen; GCS,
Glasgow Coma Scale; ICU, intensive care unit; ISS, injury
severity score.

Table 4 Interventions and significant results for randomized
prospective studies

 Intended intervention


Reference Control Degrees Per hour

Kelley et al (36) Turned a mean of NR 8
 12 times a day
Gentilello et al Turned every 2 hours NR NR
Summer et al (38) Turned every 2 hours NR NR
Demarest et al Turned every 2 hours NR NR
Fink et al (39) No comment NR NR
Clemmer et al Turned every 2-4 72 NR
 (53) hours
Nelson and Choi Turned every 2 hours NR NR

Shapiro and No comment NR NR
 Keegan (54)
deBoisblanc et al Turned every 2 hours 45 8
Whiteman et al Turned every 2 hours 30 8
Traver et al (51) Turned every 2 hours Up to 40 3
Raoof et al (57) Turned every 2 hours 45 4
MacIntyre et al No comment 32 8
McLean (52) Turned every 2 hours 45 2
Kirschenbaum et Turned every 2 hours 30 NR
 al (48)
Ahrens et al (61) Turned every 2 hours 40 2

 Intended intervention

Reference Control Hours/day Other

Kelley et al (36) Turned a mean of NR
 12 times a day
Gentilello et al Turned every 2 hours 24
Summer et al (38) Turned every 2 hours 24
Demarest et al Turned every 2 hours 24
Fink et al (39) No comment NR
Clemmer et al Turned every 2-4 24
 (53) hours
Nelson and Choi Turned every 2 hours 20
Shapiro and No comment NR
 Keegan (54)
deBoisblanc et al Turned every 2 hours [greater
 (47) than or
 to] 18
Whiteman et al Turned every 2 hours NR 30-s pause
 (49) at full
 rotation and
Traver et al (51) Turned every 2 hours NR 5-min pause on
 each side
Raoof et al (57) Turned every 2 hours [greater 20 min
 than or percussion
 equal every 4 hours
 to] 18
MacIntyre et al No comment 24
McLean (52) Turned every 2 hours 18 10 min pause on
 each side,
 5 min supine
Kirschenbaum et Turned every 2 hours 18 10 min
 al (48) percussion
 and vibrate
 every 2 hours
Ahrens et al (61) Turned every 2 hours NR Pause 10
 minutes on
 sides and
 5 min when

Reference Control Intervention achieved

Kelley et al (36) Turned a mean of Mean 200 times/day
 12 times a day

Gentilello et al Turned every 2 hours Slightly more than 50% of
 (37) the time (13.4 hours/day,
 N = 15)
Summer et al (38) Turned every 2 hours No comment

Demarest et al Turned every 2 hours Mean 12.2 hours/day
 (50) (range 7.1-16.3)
Fink et al (39) No comment Most 40[degrees] bilaterally
 for 10-16 hours/day

Clemmer et al Turned every 2-4 17.1 hours/day
 (53) hours
Nelson and Choi Turned every 2 hours All [greater than or equal
 (43) to] 16 hours/day
Shapiro and No comment Rotation from 42[degrees]
 Keegan (54) to 62[degrees] each side,
 mean 14 hours/day
 (range 1-22)
deBoisblanc et al Turned every 2 hours No comment
Whiteman et al Turned every 2 hours No comment
Traver et al (51) Turned every 2 hours Mean rotation 25.5[degrees]
Raoof et al (57) Turned every 2 hours No comment

MacIntyre et al No comment Rotation on 94% of patient
 (58) days, mean rotation
 approximately 20[degrees],
 mean 137 rotations/day
McLean (52) Turned every 2 hours No comment

Kirschenbaum et Turned every 2 hours No comment
 al (48)
Ahrens et al (61) Turned every 2 hours Mean rotation time >12
 hours but <18 hours

 Significant differences
 between treatment and
Reference Control control groups

Kelley et al (36) Turned a mean of Risk of any infection
 12 times a day (pneumonia or urinary
 tract infection or sepsis)
 2.9 times less (pneumonia
 alone 28% vs 52%), risk
 of multiple infections
 6.4 times less
Gentilello et al Turned every 2 hours Combined atelectasis and/or
 (37) pneumonia (33.3% vs 65.8%)
Summer et al (38) Turned every 2 hours Patients with sepsis and
 chronic obstructive
 airways disease had
 shorter ICU stay; patients
 with chronic obstructive
 airways disease had fewer
 days of mechanical
Demarest et al Turned every 2 hours Less atelectasis and/or
 (50) pneumonia in those who
 started with normal
 findings on a chest
 radiograph (1/9 in
 treatment group vs 5/6)
Fink et al (39) No comment Fewer lower respiratory
 tract infections (25.5%
 vs 58.3%), less pneumonia
 (13.7% vs 39.6%), shorter
 median hospital stay (20
 days vs 37 days)
Clemmer et al Turned every 2-4 No significant differences
 (53) hours
Nelson and Choi Turned every 2 hours No significant differences
Shapiro and No comment No significant differences
 Keegan (54) but mismatched groups;
 ISS controls 29, ISS
 rotation 45
deBoisblanc et al Turned every 2 hours Pneumonia less (9% vs 22%)
Whiteman et al Turned every 2 hours Fewer respiratory tract
 (49) infections (36.4% vs
 58.3%), and time to
 onset delayed
Traver et al (51) Turned every 2 hours No significant differences
Raoof et al (57) Turned every 2 hours Atelectasis resolved
 partially or completely
 (14.3% vs 82.3%), higher
 on days 3,7, and 10
MacIntyre et al No comment Fewer urinary tract
 (58) infections (11% vs 27%)
McLean (52) Turned every 2 hours No statistical analysis

Kirschenbaum et Turned every 2 hours Lower prevalance (17.5% vs
 al (48) 50%), delayed onset of
 pneumonia (29 vs 12 days)
Ahrens et al (61) Turned every 2 hours Pneumonia less (14% vs 33%),
 lobar atelectasis less
 (16% vs 31%)

Abbreviations: ICU, intensive care unit; ISS, injury severity
score; NR, not reported.
COPYRIGHT 2007 American Association of Critical-Care Nurses
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Title Annotation:CE Article
Author:Waldmann, Carl
Publication:American Journal of Critical Care
Date:Jan 1, 2007
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