Risky rice.A little-known Sacramento-based company, Ventria Biosciences, tried to get a California permit for commercial cultivation of rice genetically engineered to produce pharmaceutical substances, despite the fact that FDA FDA
Food and Drug Administration
n.pr See Food and Drug Administration.
n.pr the abbreviation for the Food and Drug Administration. , EPA EPA eicosapentaenoic acid.
n.pr See acid, eicosapentaenoic.
n. , and USDA USDA,
n.pr See United States Department of Agriculture. reviews had not been completed and federal permits had not been obtained. It won narrow approval from the California Rice Commission for an emergency process giving the California Secretary of Agriculture only 10 days to decide, blocking the normal public comment process.
The Rice Commission's lawyer falsely advised them that they could not deny the application; his law firm works for other biotech companies developing GE rice varieties.  This would be the first commercialization of a GE pharmaceutical food crop.
Such a precedent-setting decision requires extra diligence.
If it's so beneficial, why can't this technology stand the light of deliberate public scrutiny, and why ram it through with such an irregular process?
Public relations describe the substances produced as extracts from human breast milk and tears, giving a motherhood and apple-pie image, but if the food supply is contaminated, we'll be dosed with uncontrolled amounts of these pharmaceuticals. Less well known is the possibility that genetic engineering could trigger a genetic meltdown in food species.
A researcher with 30 years experience noted: "Our experiment showed up how imprecise the [genetic engineering] technique is, because we had two GM potatoes, both contained GNA GNA Ghana News Agency
GNA Globewide Network Academy
GNA Georgia Nurses Association
GNA Galanthus Nivalis Agglutinin
GNA Grand National Alliance (Pakistan)
GNA Greater Nanticoke Area lectin lectin /lec·tin/ (lek´tin) any of a group of hemagglutinating proteins found primarily in plant seeds, which bind specifically to the branching sugar molecules of glycoproteins and glycolipids on the surface of cells. , and both came from the same pot. They were both grown in greenhouses or in fields in tunnels under identical conditions and at the same time. Yet they came out different. The only explanation is that the incorporation of the transgene transgene
a gene that has been incorporated into the genome of another organism. into the host genome happened at two different places. And the effect on the genome was different.... With our two lines of potato, which should have been substantially equivalent to each other, we found that one of the lines contained 20% less protein than the other. So the two lines were not substantially equivalent to each other. But we also found that these two lines were not substantially equivalent to their parent." 
One obvious corollary of this is that each gene insertion line and each generation of each insertion must be separately tested and approved.
DNA DNA: see nucleic acid.
or deoxyribonucleic acid
One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. tends to be unstable and prone to recombine re·com·bine
To undergo or cause genetic recombination; form new combinations. . The artificial GE mechanisms enabling insertion of foreign genes also enable them to jump out and re-insert somewhere else, possibly resulting in a cascade of different mutant combinations over multiple generations, each with different properties, including possibly greater toxicity. [3,4,5]
This cascade of genetic rearrangements can stress the organism's ability to cope. It may take a number of generations for these disruptions to accumulate. If they exceed the organism's coping mechanisms, the result can be extinction of those populations. [6,7,8,9]
If this instability accumulates quickly, in a small number of generations, it will tend to be self-limiting. If it happens slowly, it may be dwarfed by other factors and limited by natural selection. The worst case is an intermediate rate slow enough that the GE genes and their ensuing instabilities spread through both GE and via cross-pollination to conventional populations, but fast enough to cause them to self-destruct generations later, resulting in extinction of both GE and conventional varieties.
Critical information of paramount importance is how many generations it can take for this process to unfold. For an annual crop like rice, this requires many years. Approval made without knowing this number would be criminally negligent.
Different growing conditions must be tested, as genetic "immune systems," including genetic mutation repair mechanisms, may be more likely to break down under real-world stresses than controlled laboratory conditions.
If it infected Asia, a genetic meltdown of rice could potentially result in the largest famine in history.
Over 3 billion people eat rice daily. Since the threat of contamination affects them, they must have a say in decisions over GE rice.
Advocates say contamination won't spread, citing rice's self-pollinating ability and experiments showing pollen drifts only to 10 feet , so buffer zones were originally set at only 100 feet.
The California Rice Commission decided buffers should be 100 miles to protect California rice growers. However this neglects to consider that birds can carry rice pollen and seeds long distances.
Bobolinks (also called Ricebirds) pass through California to their winter homes (typically rice fields) in Argentina, Bolivia, Brazil, and Paraguay.  Their range has shifted westward, so historical records will likely underestimate their future abundance. 
All these countries grow rice. Argentina is negotiating to export rice to South Korea.  100 bird species migrate through Korea, with destinations including Japan and China. [14,15] Thus there's a route for genetic contamination to go from Southern California to the heartlands of rice cultivation in Asia, even though Southern California is 100 miles away from the nearest commercial rice fields.
Black Terns formerly bred in rice fields as far south as Kern County, so they're liable to do so again if rice fields reappear. 
They pass through Mexico, which grows rice.
a. 1. Tawny; dull yellow, with a mixture of gray and brown. Whistling-Ducks aren't common now but were numerous in Southern California when rice was grown there, so they're liable to return if rice fields reappear. They winter in Cuba, Greater Antilles, and Trinidad, all of which grow rice. 
350 bird species travel between California and Central or South America, and/or between Southern and rice-growing Northern California. 
Migrant farmworkers can spread seeds and pollen in mud on shoes and clothes.
Rice experts called in when problems arise will also visit conventional rice fields, and could inadvertently spread GE seeds and pollen.
Unexpected floods will wash seeds and pollen downstream into mud which can be picked up by shoes of fishermen or hikers (who could be vacationing conventional rice growers!) and carried to their homes.
Genetically engineered contamination has been widespread in places where planting GE crops was illegal. [19,20] GE Starlink genes turned up in the US food supply despite being illegal for use as food.
A regulatory framework based on the chemical contamination model, where a small amount of contamination has a small effect, is utterly inappropriate and inadequate when dealing with reproducing organisms.
One grain of mutant rice arriving in a rice-growing area could sprout, make pollen and seeds, and then year after year the contamination could spread until it's pervasive. Scientific experiments have found that a genetically engineered gene was 20 or more times more likely to spread than the same gene induced by mutation. 
Genetic contamination has spread over large areas in just a few years. [22,23]
Contamination of food is not the only problem we have to worry about.
GE mechanisms are designed to overcome natural barriers between species, so they are liable to result in unexpected recombinations and transfers of genes among different species. Bacteria are uncontrollable, and different species of bacteria can exchange genetic material through conjugation conjugation, in genetics
conjugation, in genetics: see recombination.
conjugation, in grammar
conjugation: see inflection. . Horizontal transfer is believed to be the primary mechanism in the resurgence of antibiotic resistant infectious diseases. GE genes have already been found to move from plant pollen into bacteria. [24,25,26] Thus once pharmaceutical genes get into bacteria they can spread through the environment and be consumed by people. If these bacteria are able to thrive in the gut, they could expose people to substantial doses of the drugs the genes are designed to produce. The substances produced in such conditions may have different toxicity than what was intended. When tryptophan tryptophan (trĭp`təfăn), organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein. , which is essentially nontoxic, was genetically engineered, differences of only 0.1% in chemical composition due to unexpected interactions resulted in substantial toxicity, including permanent disabilities and deaths. 
Actually, Ventria's GE rice produces substances that are chemically different from human analogs, so they must be tested for allergenicity. [28,29]
Even if identical, substances that help people with some conditions may harm those with other conditions. Lysozyme lysozyme: see immunity.
An enyme that was first identified and named by Alexander Fleming, who recognized its bacteriolytic properties. (one of the substances Ventria's GE rice is designed to produce) may aggravate pulmonary emphysema pulmonary emphysema
See emphysema. .  Variant types of lysozyme have been linked to amyloidoses. [31,32]
n an iron-binding protein found in the specific granules of neutrophils where it apparently exerts an antimicrobial activity by withholding iron from ingested bacteria and fungi. (also produced by Ventria's GE rice) has been implicated as a factor in autoimmune diseases. [33, 34] A lactoferrin variant has been implicated in amyloidosis Amyloidosis Definition
Amyloidosis is a progressive, incurable, metabolic disease characterized by abnormal deposits of protein in one or more organs or body systems. .  Lactoferrin has been implicated in a death. 
Lactoferrin is an antibiotic. The number of microorganisms in a healthy human digestive system is larger than the number of cells in all the rest of the body, and most of them are beneficial. Killing friendly bacteria can cause disease from higher levels of harmful species. Some say it's more effective to do the opposite, namely increase beneficial bacteria. 
While an iron source like lactoferrin may help the iron-deficient , it may harm the majority of people. Iron is an oxidant oxidant /ox·i·dant/ (ok´si-dant) the electron acceptor in an oxidation-reduction (redox) reaction.
See oxidizer. , so it does the opposite of antioxidants Antioxidants
Substances that reduce the damage of the highly reactive free radicals that are the byproducts of the cells.
Mentioned in: Aging, Nutritional Supplements
n. which counter free radical damage. 
According to the National Institutes of Health, "Iron deficiency is uncommon among adult men and postmenopausal post·men·o·paus·al
Of or occurring in the time following menopause.
postmenopausal Change of life Gynecology adjective Referring to the time in ♀ when menstrual periods stop for ≥ 1 yr women.
"Iron has a moderate to high potential for toxicity because very little iron is excreted from the body. Thus, iron can accumulate in body tissues and organs when normal storage sites are full.... Accumulation of iron can result in increased production of free radicals." 
Human proteins produced by GE rice may leach from living and decomposing plants into the environment. Indeed, some have proposed collecting products from GE pharmaceutical crops via root exudates. [41,42] Bt protein from GE crops leaches through soil.  Proteins from GE rice presumably pre·sum·a·ble
That can be presumed or taken for granted; reasonable as a supposition: presumable causes of the disaster. would do likewise, contaminating water sources and dosing people and animals.
We must ensure companies pay for the consequences of their actions.
One way to do this is require companies to post bonds large enough to cover all costs of damage. Since a reproducing organism could affect hundreds of millions of people for hundreds of years, the size of these bonds would be quite large.
It makes no sense to rush with so many unresolved health, ecological, and economic issues. Rice has been grown for thousands of years; taking several decades to figure out the implications is a prudent minimum time.
The good news is that Ventria's emergency petition was rejected, and there will be more opportunities for public involvement.
The bad news is that this and other GE products are still in the pipeline, posing threats to food security if not enough people speak up and take action.
1. Center for Food Safety May 11, 2004 Press Release, http://www.centerforfoodsafety.org/page312.cfm
2. Dr Arpad Pusztai interview, GM-FREE Vol. 1, no. 3 August/September 1999, http://members.tripod.com/~ngin/pusztai.htm
3. Joe Cummins: GM Crops May All Be Unstable, ISIS Report April 8, 2001, www.i-sis.org.uk/unstable.php
4. Horvath, H, Jensen, L, Wong, O, Kohl, E, Ullrich, S, Cochran, J, Kannangara, C, von Wettstein, D: "Stability of transgene expression, field performance and recombination recombination, process of "shuffling" of genes by which new combinations can be generated. In recombination through sexual reproduction, the offspring's complete set of genes differs from that of either parent, being rather a combination of genes from both parents. breeding of transformed barley lines" 2001 Theor Appl Genet genet: see civet. 2001, 1-11
5. Palevitz, B: "DNA surprise: Monsanto discovers extra sequence in its Roundup Ready soybeans" 2000 The scientist 14,20 (july 24).
6. Joe Cummins: GM Crops May Face Genetic Meltdown, ISIS Report June 12, 2001, www.isis.org.uk/meltdown.php
7. Labra la·bra
Plural of labrum. M, Savini C, Bracale M, Pelucchi N, Columbo L, Bardini M, Sala F: Genomic changes in transgenic rice plants produced by infecting calli with Agrobacterium tumefacians. 2001 Plant Cell Reports 2001
8. Agrawal G, Yamazaki M, Kobayashi M, Hirochika R, Miyao A, Hirochika H: Screening of rice viviparous viviparous /vi·vip·a·rous/ (vi-vip´ah-rus) giving birth to living young which develop within the maternal body.
adj. mutants generated by endogenous retrotransposon retrotransposon, retroposon
a mobile sequence of DNA that transposes via a RNA intermediate. Tos17 insertion tagging of a zeanthin epoxidase4 gene and a novel OsTATC gene. Plant Physiology, 2001, 125, 1248-57
9. Gressel, J: "Molecular biology of weed control" 2000 Transgenic Res 9,355-82.
10. San Luis Obispo San Luis Obispo (săn l`ĭs ōbĭs`pō), city (1990 pop. 41,958), seat of San Luis Obispo co., S Calif., near San Luis Obispo Bay; inc. 1856. Tribune 3/30/2004, http://www.kansascity.com/mld/kansascity/news/8312059.htm
11. Arizona Game and Fish Department Heritage Data Management System: Dolichonyx oryzivorus, www.azgfd.com/w_c/edits/documents/Dolioryz.d.pdf
12. Audubon Society Field Guide to North American Birds <onlyinclude> This list of North American birds is a comprehensive listing of all the bird species known from the North American continent north of Mexico. </onlyinclude> , Western Region
13. Oryza Corporation rice market information service, http://oryza.com/news/index.shtml
14. Bird-watching directory, Korean Overseas Information Service, http://www.korea.net/directory/List.asp?Category_id=d00209
15. Wetlands and Birds Korea, http://www.wbkenglish.com
16. Point Reyes Bird Observatory: Black Tern, www.prbo.org/cms/docs/ecol/blte.pdf
17. Arizona Game and Fish Department Heritage Data Management System: Dendrocygna bicolor bicolor
a coat color of two colors. In dogs, usually black with tan markings but may be other combinations such as ticking on a white background. In cats, more than two spots of color on the body, either white and one basic color, or white with one tabby color. , www.azgfd.com/w_c/edits/documents/Dendbico.d.pdf
18. Follow the Pacific Flyway flyway: see migration of animals. in California State Parks This is a list of state parks and reserves in the California state park system.
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19. Genetic Modification Taints Corn in Mexico, Carol Kaesuk Yoon, New York Times October 2, 2001
20. Dr. Mae-Wan Ho: Transgenic Pollution by Horizontal Gene Transfer “HGT” redirects here. For other uses, see HGT (disambiguation).
Horizontal gene transfer (HGT), also Lateral gene transfer (LGT), is any process in which an organism transfers genetic material to another cell that is not its offspring. , http://www.isis.org/TransgenicPollution.php
21. J. Bergelson et al., "Promiscuity in transgenic plants," Nature 395: 25, September 3, 1998
22. Superweeds Invade Farm Fields, Tom Spears, The Ottawa Citizen 6 Feb 2001
23. GM fields spread new superweeds, Jonathan Leake, Sunday Times (London), August 12, 2001
24. Dr. Mae-Wan Ho: Horizontal Gene Transfer, http://www.i-sis.org.uk/horizontal.php
25. Dr. Mae-Wan Ho: Genetic Engineering: Dream or Nightmare, p18-20
26. Institute of Science in Society News #4 March 2000, www.i-sis.org/i-sisnews4.htm
27. John Fagan: Tryptophan summary, www.psrast.org/jftrypt.htm
28. April 1, 2004 Letter to CDFA CDFA California Department of Food and Agriculture
CDFA Council of Development Finance Agencies
CDFA Certified Divorce Financial Analyst
CDFA Community Development Finance Association
CDFA Community Development Finance Authority Secretary, http://www.organicconsumers.org/ge/riceletter040504.cfm
29. Michael Hansen, Consumer Policy Institute/Consumers Union, City Visions April 12, 2004, http://www.cityvisionsradio.com/archive/040412.htm
30. Cantor, J, Shteyngart, B, Cerreta, J, Turino, G: "The Effect of Lysozyme on Elastase-Mediated Injury", 2002 Exp Biol Med 227:108-13.
31. Hawkins, P: "Hereditary systemic amyloidosis with renal involvement", 2003 J. Nephrol. 16, 443-8
32. Vallelx, S, Drunat, S, Philit, J, Adoue, D, Piette, J, Droz, D, Macgregor, B, Canet, D, Delpech, M, Grateau, G: "Hereditary renal amyloidosis caused by a new variant lysozyme W64R in a French family", 2002 Kidney International 61, 907-12
33. Nassberger L, Hultquist R, Sturfelt G: "Occurrence of anti-lactoferrin antibodies in patients with systemic lupus erythematosus Systemic Lupus Erythematosus Definition
Systemic lupus erythematosus (also called lupus or SLE) is a disease where a person's immune system attacks and injures the body's own organs and tissues. Almost every system of the body can be affected by SLE. , hydralazine-induced lupus, and rheumatoid arthritis," 1994 Scand J Rheumatol. 23, 206-10
34. Coremans I, Hagen E, Daha M, van der Woude F, van der Voort E, Kleijburgvan der Keur C, Breedveld F: "Antilactoferrin antibodies in patients with rheumatoid arthritis are associated with vasculitis Vasculitis Definition
Vasculitis refers to a varied group of disorders which all share a common underlying problem of inflammation of a blood vessel or blood vessels. The inflammation may affect any size blood vessel, anywhere in the body. ," 1992 Arthritis Rheum rheum (rldbomacm) any watery or catarrhal discharge.
A watery or thin mucous discharge from the eyes or nose.
any watery or catarrhal discharge. . 35, 1466-75.
35. Ando, Y: "Analyses of pathogenesis and therapeutic approaches for hereditary amyloidosis", 2003 Rinsho Byori 51, 530-5
36. Tsokos M, Paulsen F: Expression of pulmonary lactoferrin in sudden-onset and slow-onset asthma with fatal outcome, Virchows Arch. 2002 Nov 441(5): 494-9
37. Jordan Rubin, Joseph Brasco: Restoring Your Digestive Health, p117, p44, p132-139
39. The Antioxidant antioxidant, substance that prevents or slows the breakdown of another substance by oxygen. Synthetic and natural antioxidants are used to slow the deterioration of gasoline and rubber, and such antioxidants as vitamin C (ascorbic acid), butylated hydroxytoluene Activities of Vitamin C and Lipoic Acid in the Body, Jung Suh, Linus Pauling Institute The Linus Pauling Institute was established at Oregon State University in August 1996 under an agreement reached between OSU and the Linus Pauling Institute of Science and Medicine (located in California from 1973 to 1996). , http://lpi.oregonstate.edu/ss02/suh.html
41. Hui, Z, Zhang, Z, Bao, Y, Liu, W, Gan, Q, An, L: "Production of functional single chain Fv protein in transgenic tobacco root exudates" 2002 Biotechnology Letters, 24, 1531-34
42. Borisjuk, N, Borisjuk, L, Sithes, L, Petersen, F, Gleba gle·ba
n. pl. gle·bae
The fleshy, spore-bearing inner mass of a puffball.
[Latin glba, clod. , Y, Raskin, I: "Production of recombinant proteins in plant root exudates" 1999 Nature Biotech 17, 466-71
43. Saxena, D, Flores Flores, town, Guatemala
Flores (flōrəs), town (1990 est. pop. 2,200), capital of Petén department, N Guatemala. Flores was built on an island in the southern part of Lake Petén Itzá and on the site of the , S and Stotzky, G: "Vertical movement in soil of insecticidal Cry 1Ab protein from Bacillus thuringinesis" 2002 Soil Biology and Biochemistry 34, 111-20