Researchers Use HelixTree(R) in First Successful Whole Genome Association Study Published for a Psychiatric Illness.BOZEMAN, Mont. -- Golden Helix, Inc. today announced that psychiatric researchers used HelixTree([R]) Genetics Analysis Software to uncover evidence of a novel genetic locus that appears to increase the risk of developing schizophrenia. The study is the first successful whole genome association study for a psychiatric illness. Results of the study were published in the high-impact journal, Molecular Psychiatry. Schizophrenia is a complex disease believed to be caused by a combination of environmental factors and genes of modest effect. Led by psychologist Todd Lencz, Ph.D. and psychiatrist Anil K. Malhotra, M.D. at The Zucker Hillside Hospital Hillside Hospital, also known as the Zucker Hillside Hospital, is an in-patient and out-patient psychiatric hospital and clinic in the borough of Queens in New York City. (ZHH ZHH Zentralverband Hartwarenhandel eV ) campus of The Feinstein Institute for Medical Research, this case-control whole genome study of roughly 500,000 single nucleotide polymorphisms (SNPs) revealed that a novel locus (rs4129148) near the CSF Cerebrospinal Fluid (CSF) Analysis Definition Cerebrospinal fluid (CSF) analysis is a laboratory test to examine a sample of the fluid surrounding the brain and spinal cord. 2RA gene was significantly associated with schizophrenia. Whole genome association is a cutting-edge technology for uncovering genes of modest effect. However, the analysis involved presents many challenges and is often daunting daunt tr.v. daunt·ed, daunt·ing, daunts To abate the courage of; discourage. See Synonyms at dismay. [Middle English daunten, from Old French danter, from Latin and difficult to perform. "HelixTree was indispensable for the successful completion of this study," according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. Dr. Lencz. "From convenient data storage to quality control testing and statistical analysis, coupled with the absolute speed of the software, HelixTree provided an integrated and comprehensive pipeline for working with whole genome data." "HelixTree was designed to be used not only by statistical geneticists This is a list of people who have made notable contributions to genetics. The growth and development of genetics represents the work of many people. This list of geneticists is therefore by no means complete. Contributors of great distinction to genetics are not yet on the list. but also other life science researchers such as Dr. Lencz who are experts in their respective fields," stated Christophe Lambert
About HelixTree([R]) Genetics Analysis Software HelixTree is a user-friendly application that incorporates a comprehensive set of SNP SNP Scottish National Party Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily analysis tools for population and family-based association studies. The software employs novel algorithms and sparse data storage technology which optimizes computational speed and memory usage enabling researchers to efficiently perform whole genome analysis with conventional computing hardware. It also offers advanced recursive partitioning technology designed to uncover hidden patterns in large complex datasets which has proven to be particularly useful for elucidating gene-gene and gene-environment interactions. HelixTree was initially developed in 1999 and has now been cited in nearly 100 peer reviewed articles. About The Feinstein Institute for Medical Research Headquartered in Manhasset, NY, and part of the North Shore-Long Island Jewish (LIJ LIJ Long Island Jewish Medical Center ) Health System, The Feinstein Institute for Medical Research is among the top six percent of all institutions that receive funding from the National Institutes of Health. Building on its strengths in neurodegenerative and psychiatric disorders, genomics and human genetics Human genetics A discipline concerned with genetically determined resemblances and differences among human beings. Technological advances in the visualization of human chromosomes have shown that abnormalities of chromosome number or structure are surprisingly , immunology and inflammation, and oncology and cell biology, its goal is to understand the biological processes that underlie various diseases and translate this knowledge into new tools for diagnosis and treatment. For more information, please visit www.FeinsteinInstitute.org. About Golden Helix, Inc. Golden Helix was founded in 1998 and has since become a leading provider of data analysis solutions designed to accelerate life science research. The company's products have been cited in nearly 100 peer reviewed articles that detail ground-breaking research for finding the genetic and environmental basis for disease and creating safer and more effective medicines. Its customers include 9 of the top 10 pharmaceutical companies and hundreds of users in the world's leading biotech, government and academic research organizations. Golden Helix is committed to Accelerating the Quest for Significance[TM]. For more information, please visit www.goldenhelix.com. |
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