Research and Markets: Kinases: From Targets to Therapeutics.Business Editors DUBLIN, Ireland--(BUSINESS WIRE)--April 28, 2004 Kinase kinase /ki·nase/ (ki´nas) 1. a subclass of the transferases, comprising the enzymes that catalyze the transfer of a high-energy group from a donor (usually ATP) to an acceptor. 2. Research Analysed Research and Markets (http://www.researchandmarkets.com) has announced the addition of Kinases: From Targets to Therapeutics to their offering. Kinases have long been recognized for their connection to cancer and inflammatory diseases Noun 1. inflammatory disease - a disease characterized by inflammation disease - an impairment of health or a condition of abnormal functioning NEC, necrotizing enterocolitis - an acute inflammatory disease occurring in the intestines of premature infants; . This CHI Insights Report shows how to exploit this major class of drug targets. This Report Offers Critical Insight Into This Market: - Commentary from leading scientific and business development experts is provided. - Strategies and technologies of the most prominent companies in kinase research are profiled. - Some of the major challenges faced by the industry are discussed. - The market potential for kinase-targeting drugs in development for a variety of diseases is evaluated. - Patient numbers for diseases of interest to developers of kinase modulators are included. Kinases: From Targets to Therapeutics reviews the considerable array of inhibitors in development for therapeutics targeting the kinase family of signal transduction Signal transduction The transmission of molecular signals from a cell's exterior to its interior. Molecular signals are transmitted between cells by the secretion of hormones and other chemical factors, which are then picked up by different cells. proteins. Protein kinases protein kinase /pro·tein ki·nase/ (pro´ten ki´nas) an enzyme that catalyzes the phosphorylation of serine, threonine, or tyrosine groups in enzymes or other proteins, using ATP as a phosphate donor. make up a veritable treasure trove TREASURE TROVE. Found treasure. 2. This name is given to such money or coin, gold, silver, plate, or bullion, which having been hidden or concealed in the earth or other private place, so long that its owner is unknown, has been discovered by accident. of targets for a variety of indications, including diabetes, inflammatory disorders, and especially cancer. The examples of Gleevec (Novartis) and Herceptin (Genentech) demonstrate that despite small markets, kinase inhibitors for cancer that are effective and cause minimal adverse effects relative to the majority of chemotherapeutic agents This is a list of specific pharmacologic agents that are known to be of use in the treatment of cancer, otherwise known as chemotherapeutic agents. This list is organized by "type" of agent, though the subsections are not necessarily definitive and are subject to revision. can enjoy strong sales. Despite this wealth of opportunity, however, kinase-modulating drugs have only recently begun to progress through clinical trials and onto the market, and the most advanced compounds target only a handful of the best-characterized kinases. This report: 1. Examines the general drug development strategies at the forefront of the effort to commercialize kinase inhibitors. 2. Surveys the projects underway at major pharmaceutical companies. 3. Details the various classes of kinases for which inhibitors are being developed, the diseases being targeted, and the companies involved. 4. One indication of the pervasiveness of the interest in kinases is the degree to which major pharmaceutical companies are involved in the development of kinase inhibitors. Some experts have observed that most, if not all, big pharma firms have programs in this area, and that they are in fact among the leaders in the field. This report is crucial reading for executives who need to stay on top of these developments. Thought Leaders Interviewed for This Report: Sean Buchanan, Structural GenomiX Inc. Allen Delaney, Kinetek Pharmaceuticals Inc. Peter Hirth, Plexxikon Tony Hunter, Salk Institute Jerry McMahon, Sugen Inc. Michael Melnick, Cell Signaling Cell signaling is part of a complex system of communication that governs basic cellular activities and coordinates cell actions. The ability of cells to perceive and correctly respond to their microenvironment is the basis of development, tissue repair, and immunity as well as Technology Inc. Wim Meutermans, Alchemia Ben Muskin, Cellular Genomics Inc. Steven Pelech, Kinexus Bioinformatics Corporation Michael Su, Vertex Pharmaceuticals Vertex Pharmaceuticals is a biotechnology company with activities spanning the length of the pharmaceutical product pipeline, from target identification through to clinical trials and marketing. Inc. James D. Winkler Winkler may refer to:
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