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Research and Markets: Development of New Pharmaceutical Approaches for Elevating HDL requires Greater Understanding of the Various Pathways in HDL -C Metabolism and their Regulation.


DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c10381) has announced the addition of 2004 HDL CHOLESTEROL - 5th Annual Metabolic Pathways and Drug Targets to their offering

This publication provides the Conference Documentation for this 5th Annual Metabolic Pathways and Drug Targets Conference.

High cholesterol levels remain a leading cause for atherosclerosis and other cardiovascular diseases, despite the multitude of available therapeutics. In order to develop new pharmaceutical approaches for elevating HDL (Hardware Description Language) A language used to describe the functions of an electronic circuit for documentation, simulation or logic synthesis (or all three). Although many proprietary HDLs have been developed, Verilog and VHDL are the major standards.  it is essential to gain a greater understanding of the various pathways in HDL -C metabolism and their regulation.

In it's 5th year, this conference provides cutting-edge data on cholesterol efflux efflux Medtalk That which flows outward , transfer proteins, scavenger receptors, nuclear receptors, hepatic lipase, ABCA ABCA American Baseball Coaches Association
ABCA American Border Collie Association
ABCA Associação Brasileira de Críticos de Arte
ABCA Ausable Bayfield Conservation Authority
ABCA American, British, Canadian, and Australian
1 and apolipoprotein apolipoprotein /apo·lipo·pro·tein/ (ap?o-lip?o-pro´ten) any of the protein constituents of lipoproteins, grouped by function in four classes, A, B, C, and E.

ap·o·lip·o·pro·tein
n.
 A.

Top experts from industry and academia present powerful strategies for reducing the risk of cardiovascular diseases by improving the atherosclerotic protection. Discover the latest developments in such topics as:

- The role of ceramide in the modulation of ABCA1-mediated cholesterol efflux

- Understanding the regulation of HDL-C HDL-C high-density-lipoprotein cholesterol.  by using natural genetic variation as a tool

- Analysis of SR-BI

- RXR RXR Retinoid X Receptor
RXR Resource Exchange Register
 agonists as regulators for dietary cholesterol

- Paraoxonase1 and it's anti-atherosclerotic properties

- LXR LXR Linux Cross Reference
LXR Luxor, Egypt - Luxor (Airport Code) 
 in lipid metabolism

- HDL-raising drugs

- Hepatic Lipase modulates lipoprotein metabolism

- Molecular dynamics of ApoA-I

- ABCA1 / apolipoprotein interactions

Conference Topics Include:

- Developing the Next Drugs for Atherosclerosis: the Promise of HDL-Raising Drugs

- Paraoxonase 1: A Multifunctional Enzyme With Anti-Atherosclerotic Properties

- Discovery of HDL376, a Novel Thiourea-Based HDL-Elevating Agent

-The Role of Nuclear Hormone Receptors in the Regulation of HDL Metabolism During Infection and Inflammation

-Second Generation RXR Agonists as Regulators of Dietary Cholesterol

- Role of LXR in Lipid Metabolism and Cardiovascular Disease

-Target Gene Regulation and HDL Induction in Mice by Liver X Receptors: Implications for Atherosclerosis and Potentially Other Diseases

-Role of Hepatic Lipase as a Multifunctional Protein that Modulates Lipoprotein Metabolism and Atherogenic ath·er·o·gen·ic
adj.
Initiating, increasing, or accelerating atherogenesis.


atherogenic adjective Referring to the ability to initiate or accelerate atherogenesis—the deposition of atheromas, lipids, and
 Risk

- Natural Genetic Variation and Its Use as a Tool in Understanding the Regulation of HDL Cholesterol

-Phase 2 Results with CETi-1, an Immunotherapeutic Vaccine to Raise HDL-C

-SCARB1: Beyond HDL-C. On the Crossroad of Diabetes and Clinical Disease

- PDZK1, a Novel PDZ Domain-Containing Protein Involved in Lipoprotein Metabolism

-Expression and Activity Modulators of the Cell Cholesterol Transporter ABCA1

-Molecular Dynamics of ApoA-I: The Complementary Roles of the N and C-terminal Regions

- Metabolic Effects of Intravenous Infusion of Apolipoprotein A-I / Phosphatidylcholine phosphatidylcholine /phos·pha·ti·dyl·cho·line/ (-ti?dil-ko´len) a phospholipid comprising choline linked to phosphatidic acid; it is a major component of cell membranes and is localized preferentially in the outer surface of the plasma  (apo a-I/PC) Discs in Humans

- Interaction of Apolipoproteins with the ABCA1 Transporter and Their Structural Motifs that Promote Lipid Efflux.

-The Role of Ceramide in the Modulation of ABCA1-Mediated Cellular Cholesterol Efflux

For more information visit http://www.researchandmarkets.com/reports/c10381
COPYRIGHT 2004 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2004, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Dec 2, 2004
Words:424
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