Research Project Grant (Parent R01).

The Research Project Grant (R01) is an award to support a discrete, specified, circumscribed project to be performed by named Project Directors/Principal Investigators (PDs/PIs) in areas representing the investigators' specific interests and competencies, based on the mission of the NIH. The R01 is the original and historically the oldest grant mechanism used by the NIH to support health-related research and development.

The NIH awards R01 grants to institutions/organizations of all types. This mechanism allows the PDs/PIs to define the scientific focus or objective of the research based on particular areas of interest and competence. Although the PDs/PIs write the grant application and are responsible for conducting and supervising the research, the actual applicant is the research institution/organization.

Research grant applications are assigned to an NIH Institution or Center (IC) based on receipt and referral guidelines and many applications are assigned to multiple ICs with related research interests.

Each IC maintains a website with funding opportunities and areas of interest. Contact with an IC representative may help focus the research plan based on an understanding of the mission of the IC. For specific information about the mission of each NIH IC, see http://www.nih.gov/icd, which provides a brief summary of the research interests in each IC and access to individual IC home pages.

This Funding Opportunity Announcement (FOA) will use the Research Project Grant (R01) award mechanism.

The applicant will be solely responsible for planning, directing, and executing the proposed project.

This FOA uses just-in-time information concepts. It also uses the modular as well as the non-modular budget formats (see http://grants.nih.gov/grants/funding/modular/modular.htm).

Specifically, if you are a U.S. organization and are submitting an application with direct costs in each year of $250,000 or less (excluding consortium Facilities and Administrative [F & A] costs), use the PHS398 Modular Budget component provided in the SF424 (R & R) Application Package and SF424 (R & R) Application Guide (see specifically Section 5.4, "Modular Budget Component," of the Application Guide).

United States applicants requesting more than $250,000 in annual direct costs and all foreign applicants must complete and submit detailed budget requests using the Research & Related Budget component found in the application package for this FOA. See NOT-OD-06-096, August 23, 2006.

Applicants must download the SF424 (R & R) application forms and the SF424 (R & R) Application Guide for this FOA through Grants.gov/Apply.

Note: Only the forms package directly attached to a specific FOA can be used. You will not be able to use any other SF424 (R & R) forms (e.g., sample forms, forms from another FOA), although some of the "Attachment" files may be useable for more than one FOA.

For further assistance, contact GrantsInfo: 301-435-0714, (telecommunications for the hearing impaired: TTY 301-451-0088) or by e-mail: [e-mail].

The application submission dates are available at http://grants.nih.gov/grants/funding/submissionschedule.htm.

The complete version of this PA is available at http://grants.nih.gov/grants/guide/pa-files/PA-07-070.html.

Contacts: The complete list of agency contacts is available at http://grants.nih.gov/grants/guide/pa-files/PA-07-070.html. Reference: PA-07-070.