Research Center for Cancer Drug Design and Discovery Established at Yale University and the National Foundation for Cancer Research.NEW HAVEN New Haven, city (1990 pop. 130,474), New Haven co., S Conn., a port of entry where the Quinnipiac and other small rivers enter Long Island Sound; inc. 1784. Firearms and ammunition, clocks and watches, tools, rubber and paper products, and textiles are among the many , Conn. -- Yale University Yale University, at New Haven, Conn.; coeducational. Chartered as a collegiate school for men in 1701 largely as a result of the efforts of James Pierpont, it opened at Killingworth (now Clinton) in 1702, moved (1707) to Saybrook (now Old Saybrook), and in 1716 was and the National Foundation for Cancer Research The National Foundation for Cancer Research was founded in 1973 as a non-profit organization under U.S. tax code 501(c)(3). Over the past 30 years, NFCR has provided more than $200 million in support of discovery-oriented basic science cancer research and cancer prevention. (NFCR NFCR National Foundation for Cancer Research NFCR National Fund for Calamity Relief (India) NFCR National Flow Cytometry Resource (Los Alamos National Laboratory) ) announced the establishment of an NFCR Center for Anti-Cancer Drug Design and Discovery to develop new beta-peptide inhibitors that will play critical roles in the fight against many types of cancer. Funded by a five-year, $750,000 grant from the NFCR, the center will be led jointly by Alanna Alanna may refer to:
"We are delighted that the NFCR has chosen to support Yale as a place where cutting-edge translational research in chemistry is making, and will continue to make, an impact in the fight against cancer," said Yale Provost Andrew Hamilton Andrew Hamilton may refer to:
The new NFCR Center will work to develop a better understanding of how [eth]-peptides can be designed to disrupt protein-protein interactions Protein-protein interactions refer to the association of protein molecules and the study of these associations from the perspective of biochemistry, signal transduction and networks. The interactions between proteins are important for many biological functions. that transmit cell signals. When proteins behave abnormally, they often send incorrect signals that result in uncontrolled cell growth and division, and cancer. In their research, Schepartz and Jogensen will focus on developing new, more effective approaches to inhibit these abnormal protein-protein interactions and thereby block transmissison of cellular signals that lead to cancer growth. Unlike the most commonly used small molecule inhibitors, [eth]-peptides have a chemical structure very similar to that of their target proteins, allowing the drug to bind the target proteins more specifically and inhibit them more effectively. The Schepartz/Jorgensen team will use both cutting-edge experimental chemistry and elegant computer modeling to design and optimize [eth]-peptide inhibitors of a wide range of targets. Since [eth]-peptides are stable within the human body, their research has the potential to create a completely new technology platform for more effective and long-lasting anticancer drugs Anticancer Drugs Definition Anticancer, or antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy. . "This new center provides a critical research platform within the worldwide network of NFCR-sponsored scientists that will significantly move our protein research to the forefront of cancer research," Schepartz said. "At Yale, we believe in the value of exploring every avenue in our quest to cure cancer, and with this partnership between NFCR and the university, we move one step closer to that goal." The NFCR Center at Yale will collaborate with scientists working in over 40 additional cancer centers and laboratories at universities and hospitals worldwide, and become a part of one of the largest cancer research networks. Other NFCR Centers are located at Oxford University, Case Western Reserve University, University of Alabama-Birmingham, the Dana Farber Cancer Institute, Translational Genomics Research Institue, Vanderbilt University Vanderbilt University, at Nashville, Tenn.; coeducational; chartered 1872 as Central Univ. of Methodist Episcopal Church, founded and renamed 1873, opened 1875 through a gift from Cornelius Vanderbilt. Until 1914 it operated under the auspices of the Methodist Church. , Freie UniversitEnt Berlin, and the Institute of Medicinal Biotechnology of the Chinese Academy of Medical Sciences in Beijing to form a broader international collaborative network of top researchers. "The NFCR Center for Anti-Cancer Drug Design and Discovery at Yale University will stimulate new approaches to drug design and development that will undoubtedly lead to novel anticancer drugs and help save lives," said Franklin Salisbury, Jr., President of the National Foundation for Cancer Research. Since it's founding in 1973, NFCR has spent more than $230 million funding basic science cancer research and cancer prevention education focused on understanding how and why cells become cancerous. NFCR is dedicated to funding scientists who are discovering cancer's molecular mysteries and translating these discoveries into therapies that hold the hope for curing cancer. For more information, visit www.NFCR.org or call 1-800-321-CURE (2873). |
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