Renal infections: an update.acquired immunodeficiency syndrome acquired immunodeficiency syndrome, see AIDS. (AIDS) nephropathy, acute and chronic pyelonephritis, renal and perirenal abscess, emphysematous pyelonephritis pyelonephritis: see nephritis.
Infection (usually bacterial) and inflammation of kidney tissue and the renal pelvis. Acute pyelonephritis is usually localized and may have no apparent cause. , emphysematous pyelitis pyelitis /py·eli·tis/ (-li´tis) inflammation of the renal pelvis.pyelit´ic
Acute inflammation of the pelvis of the kidney, caused by bacterial infection. , malacoplakia, diffuse and focal xanthogranulomatous pyelonephritis, fungal infections, tuberculosis (TB), and replacement lipomatosis. The authors will review multimodality imaging findings and pitfalls of renal inflammatory diseases.
Acute pyelonephritis (APN) refers to any inflammation affecting the renal interstitium. Patients most often affected are females from 15- to 40-years-old. Predisposing conditions include difficulty in urine retention, a patient or family history of urinary tract infections, neuropathic bladder, prolonged catheter drainage, urine reflux, bladder malignancy, obstruction, calculus disease, altered host resistance, congenital anomalies, analgesic abuse, diabetes, sexual activity, pregnancy, and long-term urinary catheterization. Acute pyelonephritis is the most common medical complication of pregnancy. Acute pyelonephritis is almost always treated as with intravenous (IV) antibiotics in an inpatient setting. It occurs more often in the second and third trimesters. However, in a recent study, 20% of cases occurred in the first trimester. (1) Factors associated with fatality include an age >65 years, septic shock, bedridden status, immunosuppression (a risk factor in men only), and recent use of antibiotics (a risk factor in women only). (2)
Infection usually originates from the lower urinary tract and ascends via subepithelial lymphatic channels or directly via the ureter. In general, Escherichia coli (E coli) is the most common pathogen. In elderly patients with a history of instrumentation, however, Proteus miranilis is a frequent cause. Escherichia coli has the ability to attach to urothelial surfaces via pili pili /pi·li/ (pi´li) [L.] plural of pilus.
plural of pilus.
pili torti or fimbriae. The kidneys become enlarged and patchy areas of inflammation can be seen in different stages. Typically, the pelvicalyceal system is involved first, spreading from the medullary region to the cortex. Hematogenous hematogenous /he·ma·tog·e·nous/ (he?mah-toj´e-nus)
1. produced by or derived from the blood.
2. disseminated through the blood stream.
1. transmission occurs less commonly; staphylococcal septicemia has been shown to have a propensity to establish renal infection. In hematogenous infections, the cortex is involved first. (3)
Radiographic findings include uniform renal enlargement, diminished nephrographic density, delayed calyceal opacification, diminished calyceal contrast density, and attenuated and distended pyelocalyceal structures. Rarely, focal calyceal compression may be seen. Dilatation of the collecting system and nodular edema of the pelvis or infundibulum infundibulum /in·fun·dib·u·lum/ (-dib´u-lum) pl. infundib´ula [L.]
1. a funnel-shaped structure.
2. conus arteriosus.
3. i. of neurohypophysis. are also reported. A striated nephrogram is a relatively common presentation (Figure 1).
Acute focal bacterial pyelonephritis
Acute focal bacterial pyelonephritis (AFBP) is seen in uncomplicated cases of APN. With medical therapy, most inflammatory masses resolve within in a few weeks without subsequent renal damage. Scarring is uncommon in uncomplicated cases in the absence of comorbid conditions. Severe diffuse bacterial nephritis may produce permanent damage such as papillary necrosis or global atrophy. The Society of Uroradiology recommends that all patients with renal infection be referred to as having APN. Additional modifiers to better describe the inflammatory process include unilateral or bilateral, focal or diffuse, and with or without focal swelling or renal enlargement.
Dimer captosuccinic acid (DMSA) technetium-99m ([sup.99m]Tc) scintigraphy scintigraphy /scin·tig·ra·phy/ (sin-tig´rah-fe) the production of two-dimensional images of the distribution of radioactivity in tissues after the internal administration of a radiopharmaceutical imaging agent, the images being obtained is both a highly sensitive (92%) and specific (93%) diagnostic study. Singlephotonemission computed tomography (SPECT) imaging has an even higher sensitivity, at 90%. (4) Dimer captosuccinic acid [sup.99m]Tc is more sensitive to the presence of renal scarring compared with IV urography urography /urog·ra·phy/ (u-rog´rah-fe) radiography of any part of the urinary tract.
ascending urography , cystoscopic urography retrograde u. (IVU) or ultrasound. Dimer captosuccinic acid [sup.99m]Tc accumulates in the proximal tubular cells.
Cortical uptake depends on blood flow and cell membrane transport. In APN, low uptake is attributed to locally reduced renal blood flow (RBF) and/or a disturbed flow mechanism. The reduced RBF is secondary to intravascular granulocyte aggregation leading to arteriolar arteriolar
emanating from or pertaining to arteriole. or capillary occlusion. Renal cortical defects present at 6-month follow-up have a high rate of ultimate resolution. It has been shown that DMSA [sup.99m]Tc scintigraphy performed 12 months after infection provides more reliable data regarding persistence of renal cortical lesions (5) (Figure 2).
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Ultrasound is not very sensitive in early or uncomplicated cases, and is less sensitive than CT and DMSA [sup.99m]Tc scans. Findings include renal enlargement and focal hypo- or hyper echoic zones of parenchyma. In children, ultrasound is useful as a screening examination to evaluate for hydro nephrosis nephrosis (nəfrō`səs), kidney disease characterized by lesions of the epithelial lining of the renal tubules, resulting in marked disturbance in the filtration function and the consequent appearance of large amounts of protein (albumin) , megaureter, and renal ectopia. Harmonic imaging with speckle reduction has the potential to increase ultrasound sensitivity for the diagnosis of pyelonephritis. Power Doppler may detect decreased flow in edematous areas and has the potential for identifying APN in children. In view of its low accuracy, however, Power Doppler is unlikely to replace DMSA [sup.99m]Tc scanning. The use of contrast-enhanced ultrasound can improve APN diagnosis and reduce interobserver variability (6-8) (Figure 3).
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Computed tomography (CT) is considered the modality of choice in the evaluation of patients with acute bacterial pyelonephritis. Recently, CT urography has been increasingly used in place of IVU. Unenhanced CT can detect calculi, gas formation, renal enlargement, hemorrhage, parenchymal calcification, obstruction, and inflammatory masses. In many cases, unenhanced CT will appear normal and contrast-enhanced scans must be performed. The nephrogram phase is considered to be superior in depicting the full extent of lesions and, in general, defines the abnormalities of APN. Dual-phase CT with pre- and postcontrast-enhanced scanning in the nephrographic phase at 70 to 90 seconds is adequate for the diagnosis. The delayed phase is indicated only if obstruction is suspected.
CT findings include perinephric abnormalities, alteration of renal contour, and parenchymal wedge-shaped areas of decreased attenuation radiating from the papilla to the cortical surface. The striated areas are thought to be due to tubular obstruction secondary to edema with intervening normal tubules. The striated nephrogram have a lobar lo·bar
Of or relating to a lobe or lobes.
Relating to a lobe, a rounded projecting part of the lungs.
Mentioned in: Congenital Lobar Emphysema
pertaining to a lobe. distribution and may be unifocal or multifocal. Calyceal effacement and pelvicalyceal wall thickening may also be seen. Multidetector CT with multiplanar reformation allows the depiction of the kidneys, ureters, and bladder in a single breath-hold. This approach can potentially help in planning image-guided drainage procedures if there is an indication of a renal or perirenal abscess (Figure 4).
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Magnetic resonance imaging magnetic resonance imaging (MRI), noninvasive diagnostic technique that uses nuclear magnetic resonance to produce cross-sectional images of organs and other internal body structures. (MRI) may be helpful in differentiating acute from chronic parenchymal defects. In addition, it can potentially be applied in patients who are pregnant, and, until recently, has been a potential alternative in patients with known renal failure (especially diabetic patients). Reports of nephrogenic systemic fibrosis (NSF) in patients with renal failure who were exposed to gadoliniun have limited the use of contrast-enhanced MRI as an alternative. In general, however, MRI is reserved as a problem-solving modality or is used under such circumstances in which other imaging studies are either contraindicated or have equivocal findings.
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Delayed recognition or inadequate treatment of APN can progress to the development of small focal abscesses that can then coalesce to form larger fluid collections. Perinephric abscesses may develop secondary to rupture into the perirenal space or secondary to parenchymal necrosis. They are usually contained within Gerota's fascia. The overall prevalence of renal scar is approximately 30% in patients who develop renal abscesses. (3) In fact, the prevalence of scar is highest in patients who develop abscesses, followed by lesions with liquefaction, and lowest in those with "simple" lesions (Figure 5).
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pertaining to or emanating from suppuration; pus in e.g. suppurative arthritis, bronchopneumonia. pyelonephritis (SPN) is a severe form of APN. This is a different entity from pyonephrosis and xantho granulomatous pyelonephritis (XGP). There is no predisposition to develop SPN in a hydronephrotic kidney.
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Septicemia related to IV drug abuse and skin infections are other causes of renal abscesses that are usually caused by Staphylococcus. Superinfection superinfection /su·per·in·fec·tion/ (-in-fek´shun) a new infection occurring in a patient having a preexisting infection, such as bacterial superinfection in viral respiratory disease or infection of a chronic hepatitis B carrier with of a renal cyst or diverticulum diverticulum
Small pouch or sac formed in the wall of a major organ, usually the esophagus, small intestine, or large intestine (the most frequent site of problems). may simulate a renal abscess. Patients with autosomal dominant polycystic kidney disease autosomal dominant polycystic kidney disease ADPKD A common–1:400-1:1000 AD condition, which causes 6-9% of ESRD in developed countries Clinical Acute or subacute onset of azotemia and HTN, due to ↑ activity of the RAA system, possibly related to the or acquired cystic disease from dialysis may develop renal abscesses if a cyst becomes infected (Figure 6). Percutaneous aspiration or drainage provides optimal nonoperative diagnosis and therapy (Figure 7).
Xanthogranulomatous pyelonephritis is a severe form of renal parenchymal inflammation that occurs in the presence of chronic obstruction and suppuration suppuration /sup·pu·ra·tion/ (sup?u-ra´shun) pyogenesis.sup´purative
The formation or discharge of pus. Also called pyesis, pyopoiesis, pyosis. . The name is derived from the yellow (xantho) color seen on gross pathology and the granulomatous reaction seen histologically. The characteristic features are replacement of normal renal parenchyma by multiple fluid-filled cavities arranged in a hydro nephrotic nephrotic /ne·phrot·ic/ (ne-frot´ik) pertaining to, resembling, or caused by nephrosis. pattern. Typically, patients are middle-aged women with a mean age of 44 to 50 years. This condition is almost always unilateral. Common signs and symptoms include malaise, fever, weight loss, flank pain and palpable mass. Laboratory results show leukocytosis Leukocytosis Definition
Leukocytosis is a condition characterized by an elevated number of white cells in the blood.
Leukocytosis is a condition that affects all types of white blood cells. , anemia, pyuria pyuria /py·u·ria/ (pi-ur´e-ah) pus in the urine.
The presence of pus in the urine, usually a sign of urinary tract infection. , hematuria hematuria
Blood in the urine. It usually indicates injury or disease of the kidney or another structure of the urinary system or possibly, in males, the reproductive system. It may result from infection, inflammation, tumours, kidney stones, or other disorders. , and positive urine culture. Pediatric XGP has a greater propensity for focal disease and a lower predilection for females. If lipidladen macrophages are absent histologically, the process represents pyonephrosis. Xanthogranulomatous pyelonephritis is always unilateral, may be focal (17% of cases) or diffuse, and does not occur with increased incidence in diabetic (10%) or AIDS patients.
Proteus mirabilis and E coli have been reported as the most common organisms associated with XGP, but a sterile urine culture is not uncommon. Urinary tract infection urinary tract infection (UTI),
n infection in one or more of the structures that make up the urinary system. Occurs more often in women and is most commonly caused by bacteria. , previous ineffective antibiotic therapy, chronic renal ischemia, abnormalities in lipid metabolism, lymphatic blockage, and impaired immunity have been suggested as etiologic factors. Coexistence of XGP and renal replacement lipomatosis as well as XGP with renal TB has been reported. CT is the most accurate imaging technique for the diagnosis of XGP.
CT findings of XGP include an enlarged kidney with a reniform reniform /ren·i·form/ (ren´i-form) kidney-shaped.
kidney-shaped. shape, poor or absent excretion of contrast media, and replacement of renal parenchyma with multiple low-density fluid-filled areas arranged in a hydro nephrotic pattern. A rim of tissue surrounding the fluid-filled cavities may be seen on post enhanced images. This represents normal parenchyma and/or an inflammatory process. There is potential for spread of the disease beyond the kidney into the peri- and pararenal space (Figure 8).
A staghorn calculus is a common XGP feature but is absent in 20% of cases. Rarely, air is seen in the renal parenchyma. Typically, perinephric stranding and thickening of Gerota's fascia is seen. Xanthogranulomatous pyelonephritis has also been called "the great imitator" because its clinical and radiological findings closely resemble other pathologic conditions such as pyelonephritis with stones, renal tuberculosis, perinephric abscess, and adenocarcinoma.
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Ultrasound of XGP shows an enlarged kidney, central echogenic foci, and multiple anechoic anechoic /an·echo·ic/ (an-e-ko´ik)
1. without echoes; said of a chamber for measuring the effects of sound.
in ultrasonography, an absence of internal echoes. or hypoechoic areas with a staghorn calculus. Associated complications (such as psoas abscess, nephrocutaneous fistula, renocolonic fistula, and paranephric abscess) can be observed, as shown in Figure 8. Complications observed in the postoperative period include bowel fistulas, draining sinuses, and delayed wound healing (9,10) (Figure 8).
Emphysematous pyelonephritis and pyelitis
Emphysematous pyelonephritis (EPN) is an acute, often fatal, necrotizing infection that is characterized by gas formation in and around the kidney. Gas-forming bacteria using glucose as a substrate cause necrotizing lesions in affected tissue. Emphysematous pyelonephritis is seen in patients with poorly controlled diabetes (87%) or in those with obstructive urinary tract infection. Obstruction is, however, not a prerequisite of the condition. The condition is twice as prevalent in women. Patients present with chills, fever, flank pain, lethargy, and confusion. Associated organisms include E coli, Klebsiella pneumoniae, Aerobacter aerogenes, and P mirabilis.
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Radiography and IVU show a mottled gas pattern with absence of excretion. On ultrasound, dense echoes are seen within the renal parenchyma that may produce the "gassed-out kidney." CT is needed to assess gas distribution (11) (Figure 9, Table 1).
Nephrectomy Nephrectomy Definition
Nephrectomy is the surgical procedure of removing a kidney or section of a kidney.
Nephrectomy, or kidney removal, is performed on patients with cancer of the kidney (renal cell carcinoma); a disease in is the most definitive and effective modality for the treatment of EPN and should not be delayed. Medical therapy should be given concomitantly. Percutaneous drainage with medical therapy can be an effective initial treatment option in inoperable cases, such as patients with poor general medical condition, solitary kidney, inadequate contralateral renal function, or bilateral EPN. (12)
Pyonephrosia is a suppurative infection in an obstructed collecting system. The spectrum ranges from recently infected hydronephrosis to an end-stage nonfunctional kidney filled with pus. More than 50% of patients have calculus formation. Xanthoma xanthoma /xan·tho·ma/ (zan-tho´mah) a tumor composed of lipid-laden foam cells, which are histiocytes containing cytoplasmic lipid material. cells are absent.
Intravenous urography and retrograde pyelography (RGP) may show fragmentation of a staghorn calculus, which is also suggestive of XGP. The renal outline may be obscured if there is perinephric extension. If the kidney is nonfunctioning, RGP may reveal the presence, site, and source of obstruction. Contrast may mix with the purulent contents, and the hydronephrotic kidney may appear distended with stringy and particulate filling defects.
Ultrasound shows moderate-to-marked hydronephrosis and echogenic shadowing calculi. The collecting system may appear echogenic because of the presence of pus and debris. CT findings are nonspecific. Hydronephrosis with high-density urine, calculi, or gas in the collecting system may be seen. Thickening of the wall of the renal pelvis may be seen, with perinephric stranding also commonly present (13) (Figure 10).
The most common etiology of chronic inflammation in children is reflux. Adults may develop chronic inflammation following severe APN pyelonephritis, particularly in diabetic patients. Other predisposing factors include obstruction, calculi, and foreign bodies. Chronic inflammatory change may be unilateral or bilateral, asymmetrical, or segmental with a scar seen overlying a blunted calyx (Figure 11). Since scars may mimic angiomyolipomas, excretory ex·cre·to·ry
Of, relating to, or used in excretion.
pertaining to excretion.
see elimination behavior. phase imaging is often used to determine the correct diagnosis. Renal replacement lipomatosis
Renal replacement lipomatosis
(RRL), also known as replacement fibrolipomatosis, develops from chronic pyelonephritis. The true pathogenesis is, however, unknown. It is commonly seen as a unilateral process, but bilateral involvement has been reported. Fibrofatty tissue replaces renal parenchyma that has atrophied because of chronic inflammation. The patient may be asymptomatic or may present with chronic inflammation, hydronephrosis, calculi, cutaneous fistula, or a frank abscess and severe renal parenchymal atrophy. Renal calculi (staghorn) are seen in 70% of cases. Pathologically, the kidney is enlarged and has a gross fibrofatty appearance. The renal cortex is extremely atrophic, but a reniform shape is usually maintained. CT is the most definitive diagnostic modality to evaluate the salient features of RRL. Major differential diagnosis includes XGP, renal tuberculosis, and angiomyolipoma or even liposarcoma. Coexisting XGP and tuberculosis with RRL have also been described. Renal replacement lipomatosis has also been reported in a renal transplant (14) (Figure 12).
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The lifetime risk of renal TB after infection has been reported to be 10%. A recent resurgence has been seen due to the human immunodeficiency virus human immunodeficiency virus
Human immunodeficiency virus (HIV)
A transmissible retrovirus that causes AIDS in humans. (HIV)/ AIDS epidemic. Approximately 70% of AIDS patients have extrapulmonary TB.
In 30% of cases, extrapulmonary TB involves the urogenital tract and occurs mostly in men. It is rare before age 20. Cases of renal TB have also been seen following intravesical Bacillus Calmette-Guerin (BCG) therapy for bladder cancer. Urine culture is the most definitive method of diagnosis. Cultures of multiple early morning urin specimens reveal sterile pyuria, microhematuria, and acidic pH. The pathological triad consists of necrotic debris, caseous-type epithelioid epithelioid /ep·i·the·li·oid/ (-the´le-oid) resembling epithelium.
Of or resembling epithelium.
resembling epithelium. histiocytes, and Langerhan's giant cells.
Both upper and lower poles are often involved. Massive destruction results in autonephrectomy. Dystrophic dystrophic
pertaining to or emanating from dystrophia.
mineralization of soft tissues can occur in hyperadrenocorticism, vitamin d toxicity, and hypervitaminosis A. See also calcification. calcifications are seen and may be amorphous, smudged, speckled, curvilinear, lobar, or a combination of the above. The lobar configuration is quite specific for TB.
Radiographs show calcification outlining the entire kidney, ureters, and bladder in advanced cases. Calcification in the seminal vesicle or vas deferens is suggestive of TB in non- diabetics. Calcification may also occur in psoas or paraspinal abscesses and in cases of abdominal or pelvic lymphadenopathy.
Early findings are best detected on IVU or RGP. In 10% to 15% of cases, however, these studies are normal. Papillary edema may be seen with "fuzzy" or feathery calyceal margins. A motheaten appearance of the calyces may be seen that represents calyceal erosion. Ragged papillae, infundibular infundibular /in·fun·dib·u·lar/ (in?fun-dib´u-lar)
1. pertaining to an infundibulum.
pertaining to any of the body's infundibula. See also infundibulum. strictures, and scarring of the renal pelvis produce a "hiked-up pelvis." In addition, parenchymal fibrosis can kink the pelvis ("Kerr's kink"). A dilated calyx that is not opacified on IVU (Figure 13) has been descibed as a "phantom calyx." The differential diagnosis for this finding includes tumor, especially transitional cell carcinoma. (15-17)
Malacoplakia is a rare granulomatous inflammatory disease that is primarily found in the urinary tract. It frequently occurs in the bladder, kidney, renal pelvis, ureters, prostate, and urethra. A positive urine culture is found in 80% to 90% of cases. Michaelis-Gutmann bodies are the histologic hallmark of the disease. Lesions appear as soft, plaquelike yellow tumor nodules of varying size (18) (Figure 14).
Renal candidiasis--At autopsy, the kidney is the most common organ found to be involved following systemic candidemia. Microscopic parenchymal and subcapsular abscesses develop in the cortex. Low-grade infections may show no abnormality. Immunocompromised patients may develop multiple microabscesses, which may calcify cal·ci·fy
To make or become stony or chalky by deposition of calcium salts.
to mineralize by the deposition of calcium salts. when healed.
Intravenous urography, ultrasound, and CT findings include papillary necrosis (noted in 21%) and infundibular stenosis. Fungus balls (eg, mycetomas, and urobezoars) can extend down the ureter as casts within the collecting system (seen as the "cat's tail sign"), and this can result in mechanical obstruction. On ultrasound, fungus balls have an echogenic appearance. Fungus balls may resemble other defects and must be differentiated from blood clots, nonopaque calculi, transitional cell cancer, squamous cell cancer Squamous cell cancer
A form of skin cancer that usually originates in sun-damaged areas or pre-existing lesions; at first local and superficial, it may later spread to other areas of the body.
Mentioned in: Cryotherapy , air bubbles, fibroepithelial polyps, cholesteatoma, and leukoplakia leukoplakia /leu·ko·pla·kia/ (-pla´ke-ah)
1. a white patch on a mucous membrane that will not rub off.
2. oral l.
atrophic leukoplakia lichen sclerosus in females. (19) (Figure 15).
Renal mucormycosis--Renal mucormycosis infection is caused by fungi of the order Mucorales and is uncommon among the HIV population, but is associated with IV drug abuse and a low CD4 count. Intravenous inoculation with spores is believed to contribute to renal dissemination. Clinically, patients have symptoms of pyelonephritis that is unresponsive to therapy. The fungal hyphae aggressively invade blood vessels, leading to hemorrhage, thrombosis, and infarction.
HIV nephropathy and infectious complications
An estimated 650,000 to 900,000 residents are currently infected with HIV in the United States. Reportedly, 38% to 60% of AIDS patients exhibit azotemia azotemia /az·o·te·mia/ (az?o-te´me-ah) uremia; an excess of urea or other nitrogenous compounds in the blood.
See uremia. , proteinuria, hematuria, or pyuria. Clinical findings may range from decreased renal function to full-blown nephrotic syndrome. This condition is more prevalent in males, blacks, and IV drug abusers. The pathogenesis is unknown. No specific treatment is available and HIV nephropathy carries a poor prognosis. Death is often reported within 6 months. An improved survival has been reported with the use of new antiviral treatments.
Ultrasound findings of HIV nephropathy include renal enlargement >13 cm in 20% of patients and increased cortical echogenicity, which is largely caused by tubulointerstitial abnormalities, in 75% of patients. This however, is not a universal finding, and a normal sonogram son·o·gram
An image, as of an unborn fetus, produced by ultrasonography. Also called echogram, sonograph, ultrasonogram. does not exclude HIV nephropathy. There is no correlation between the degree of echogenicity and the severity of renal disease. Thickening of the pelvicalyceal wall may also be seen (this is also seen in reflux and acute tubular necrosis acute tubular necrosis Nephrology A pathologic change of acute renal failure due to shock, crush injuries, hemoglobinuria, toxic nephrosis, sepsis, drugs-aminoglycosides, amphotericin B, cyclosporine, radiocontrast, ischemia in transplanted kidneys Predisposing ). One should always suspect HIV-associated nephropathy with bilateral increased cortical echgenicity (20) (Figure 16).
CT findings of HIV nephropathy include decreased corticomedullary differentiation, decreased renal sinus fat, and parenchymal heterogeneity. Renal enlargement with a striated nephrogram and a globular renal configuration can also be seen.
In HIV patients, however, other conditions may be responsible for poor renal function, including nephrotoxic antibiotics or acute tubular necrosis caused by shock, sepsis, or dehydration. Also, opportunistic infections occur with the CD4 cell count as the best predictor of risk. Cystitis and pyelonephritis may occur in 50% of cases. Urinary infections may be due to typical or atypical organisms. Atypical infectious causes include TB, Mycobacterium avium-intercellulare, Pneumocystis carinii, Cytomegalovirus, Candida, and toxoplasmosis. (21)
Extrapulmonary Pneumocystis carinii pneumonia Pneumocystis carinii pneumonia (PCP)
A lung infection that affects people with weakened immune systems, such as people with AIDS or people taking medicines that weaken the immune system.
Mentioned in: AIDS, Antiprotozoal Drugs, Sulfonamides in AIDS
Pneumocystis carinii pneumonia (PCP PCP
2. primary care physician
Pneumocystis carinii pneumonia (PCP) ) is the most common opportunistic infection in AIDS patients. Chemoprophylaxis is recommended if the CD4+ T lymphocyte count is <200 cells/uL, or there is a history of oral candidiasis or unexplained fever. Risk factors include low CD4 count, history of other infections, PCP pneumonia, and history of aerosolized pentamidine pentamidine /pen·tam·i·dine/ (pen-tam´i-den) an antiinfective used as the isethionate salt in the treatment of pneumonia, leishmaniasis, and early African trypanosomiasis. .
Radiographic findings include multiple punctate punctate /punc·tate/ (punk´tat) spotted; marked with points or punctures.
Having tiny spots, points, or depressions. and rimlike calcifications in the spleen, liver, kidneys, lymph nodes, and adrenal glands. A differential diagnosis includes infection with M avium-intercellulare, cytomegalovirus infection, and fungal infections.
Mavium-intracellulare in AIDS
Infection with Mycobacterium avium-intercellulare is extremely common in patients with advanced AIDS. Imaging shows bulky low-attenuation nodal masses in the retroperitoneum, mesentery mesentery: see peritoneum. , renal hila, and periaortic locations, mimicking lymphoma and Kaposi's sarcoma. Nephrocalcinosis may also be seen. These masses often exhibit central necrosis, and, less commonly, calcifications. (22)
Tuberculosis in AIDS
Individuals infected with HIV are at substantial risk for TB. Extrapulmonary TB is common at any stage and populations at increased risk include IV drug abusers, blacks, Hispanics, and Haitians. Sterile pyuria is seen, and urographic manifestations are similar to those in non-AIDS patients. Abscesses may be seen in multiple locations. Tuberculosis may affect the epidydimis with enlargement and hyperechogenicity and the testes with enlargement and hypo echo genicity. A gallium scan may be of help in localizing sites of involvement.
Most patients with acute pyelonephritis do not require any diagnostic imaging procedures. However, further work-up may be necessary in patients with recurrent infections or chronic illness or in symptomatic individuals in whom urinary tract infection cannot be documented. A variety of imaging studies will detect morphologic and functional changes of the kidney in response to inflammation. Selection and interpretation of these imaging modalities requires knowledge of the clinical and radiologic manifestations of infection, including pitfalls in diagnosis.
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Syed A. Akbar, MD, Syed Z. H. Jafri, MD, FACR, Marco Amendola, MD, and Bridget Wiater, MD
Dr. Akbar is the Medical Director of Radiology, Rush Copley Medical Center, Aurora, IL; Dr. Jafri is Head of Genito urinary Radiology, and Dr. Wiater is a Staff Radiology, Department of Diagnostic Radiology, William Beaumont Hospital, Royal Oak, MI; Dr. Amendola is Head of Genitourinary Radiology, University of Miami, Miami, FL.
Table 1. Stages of emphysematous pyelonephritis and pyelitis Stage 1 Gas in parenchyma or perinephric tissues Stage 2 Gas in both kidneys and their surroundings Stage 3 Extension through Gerota's fascia and/or bilateral
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|Author:||Akbar, Syed A.; Jafri, Syed Z.H.; Amendola, Marco; Wiater, Bridget|
|Article Type:||Clinical report|
|Date:||Mar 1, 2009|
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