Regeneron obtains United States patent.Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) has patented methods of creating mutations in genomic genomicpertaining to a genome. genomic clone see clone. genomic DNA the DNA sequences making up the genome of an individual. genomic library see gene bank. exons by inserting introns into the genomic exons via homologous recombination Homologous recombination is a type of genetic recombination, a process of physical rearrangement occurring between two strands of DNA. Homologous recombination involves the alignment of similar sequences, a crossover between the aligned DNA strands, and breaking and repair of the . Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the genome comprising the genomic exon Exon In split genes, a portion that is included in the ribonucleic acid (RNA) transcript of a gene and survives processing of the RNA in the cell nucleus to become part of a spliced messenger RNA (mRNA) or structural RNA in the cell cytoplasm. does not contain the modification are provided. The methods provide for a rapid method for introducing mutations and/or modifications of any type into a mammalian mammalian emanating from or pertaining to mammals. cell genome. (US 7,205,148) |
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