Regeneron obtains United States patent.
Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) has patented methods of creating mutations in genomic genomic
pertaining to a genome.
the DNA sequences making up the genome of an individual.
see gene bank. exons by inserting introns into the genomic exons via homologous recombination Homologous recombination is a type of genetic recombination, a process of physical rearrangement occurring between two strands of DNA. Homologous recombination involves the alignment of similar sequences, a crossover between the aligned DNA strands, and breaking and repair of the . Also, methods are provided for introducing modifications into genomic exons by inserting introns into the genomic exons via homologous recombination such that a mature mRNA transcript produced from a genomic region of the genome comprising the genomic exon Exon
In split genes, a portion that is included in the ribonucleic acid (RNA) transcript of a gene and survives processing of the RNA in the cell nucleus to become part of a spliced messenger RNA (mRNA) or structural RNA in the cell cytoplasm. does not contain the modification are provided. The methods provide for a rapid method for introducing mutations and/or modifications of any type into a mammalian mammalian
emanating from or pertaining to mammals. cell genome. (US 7,205,148)