Regeneron obtains United States patent.
Regeneron Pharmaceuticals, Inc. (Tarrytown, NY) has patented
methods of creating mutations in genomic exons by inserting introns into
the genomic exons via homologous recombination. Also, methods are
provided for introducing modifications into genomic exons by inserting
introns into the genomic exons via homologous recombination such that a
mature mRNA transcript produced from a genomic region of the genome
comprising the genomic exon does not contain the modification are
provided. The methods provide for a rapid method for introducing
mutations and/or modifications of any type into a mammalian cell genome.