Recent Independent Study Shows Microfluidizer Processors Speed Development of Gene Therapies to Produce Recombinant Adenoviruses.Business/Biotechnology Editors & Health/Medical Writers NEWTON, Mass.--(BW HealthWire)--April 16, 2001 Adenoviruses are genetically modified viruses used in gene therapy to treat cystic fibrosis cystic fibrosis (sĭs`tĭk fībrō`sĭs), inherited disorder of the exocrine glands (see gland), affecting children and young people; median survival is 25 years in females and 30 years in males. , cancer and (potentially) other diseases. One of the more time consuming steps in the manufacture of recombinant Adenoviruses (rAd) is the manual lysing (disruption) of mammalian cells in which rAd are cultivated. Freeze-thaw cycles are commonly used to lyse lyse (liz) 1. to cause or produce disintegration of a compound, substance, or cell. 2. to undergo lysis. lyse or lyze v. To undergo or cause to undergo lysis. mammalian cells, taking up to 6 hours to process a 1.5-liter batch of cellular material. However, in a recent comparative study by Cobra Therapeutics in Staffordshire, England, the Microfluidizer(R) materials processor, processed the same size batch in only 2 hours, with no detrimental effects on the virus yields or infectivity. The continuous processing capability of the Microfluidizer processor provides additional safety benefits as it limits human interaction with the cells, reducing the risk of employee contamination. Processing larger amounts of cell suspensions results in even greater savings of time and labor expenses. The Microfluidizer processor is based on a patented high-shear fluid processing technology, used for cell lysing and the preparation of vaccines, parenterals, encapsulation (1) In object technology, the creation of self-contained modules that contain both the data and the processing. See object-oriented programming. (2) The transmission of one network protocol within another. (liposomes Liposomes Aqueous compartments enclosed by lipid bilayer membranes; liposomes are also known as lipid vesicles. Phospholipid molecules consist of an elongated nonpolar (hydrophobic) structure with a polar (hydrophilic) structure at one end. ) and preparation of uniform submicron particles. Microfluidizer processors are available in lab, pilot and production scale units and are currently used by most leading biotech, genomics, pharmaceutical and biopharmaceutical companies, worldwide, in both cell lysing and drug formulation applications. Microfluidics is a division of MFIC MFIC Malaysian Furniture Industry Council MFIC Microfluidics International Corp. MFIC Military Flight Information Center MFIC Missionary Franciscan of the Immaculate Conception (religious order) Corporation, which is traded under the symbol "MFIC" on the NASDAQ NASDAQ in full National Association of Securities Dealers Automated Quotations U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on OTCBB OTCBB See OTC Bulletin Board (OTCBB). MFIC CORPORATION MFIC Corporation, through its Microfluidics Division, provides patented and proprietary, high performance Microfluidizer(R) materials processing equipment to the chemical, pharmaceutical, biotechnology, cosmetic/personal care, and food processing industries. Through its Morehouse-COWLES Division, the Company provides leading equipment, and innovative technology and solutions to the chemicals, paints, pigments and coatings industries for mixing, milling, dispersing and dissolving. The combined resources and capabilities of the Company's equipment lines are used to provide comprehensive solutions to materials processing. |
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