Radiological case of the month: Hyo-Jeong Lee, MD.CASE SUMMARY
A 68-year-old man with a long history of uncontrolled hypertension presented with a single 4-minute episode of a generalized tonic-clonic seizure generalized tonic-clonic seizure
See grand mal seizure.
generalized tonic-clonic seizure Generalized seizure, grand mal seizure, tonic-clonic seizure Neurology A seizure of the entire body, characterized by muscle , and 2 days of fluctuating headache, visual disturbance, nausea, and vomiting. On neurologic examination, he was drowsy but able to follow simple commands. He had no focal neurologic deficit. The physical examination revealed a blood pressure of 230/75 mm Hg and no pedal edema. The fundoscopic examination was normal.
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Magnetic resonance imaging magnetic resonance imaging (MRI), noninvasive diagnostic technique that uses nuclear magnetic resonance to produce cross-sectional images of organs and other internal body structures. (MRI) and magnetic resonance angiography Magnetic resonance angiography
A noninvasive diagnostic technique that uses radio waves to map the internal anatomy of the blood vessels.
Mentioned in: Cerebral Aneurysm
magnetic resonance angiography (MRA) of the brain were performed with a GE Signa LX 1.5T MRI scanner (GE Healthcare, Waukesha, WI). Contrast media (Magnevist, gadopentetate dimeglumine, Berlex Laboratories, Montville, NJ) was injected intravenously (0.1 mmol/kg body weight). The MRI showed bilateral symmetric vasogenic edema mainly involving the subcortical subcortical /sub·cor·ti·cal/ (-kor´ti-k'l) beneath a cortex, such as the cerebral cortex. white matter in the parieto-occipital, posterior temporal, and posterior frontal lobes (Figure 1). The MRA of the vertebrobasilar system was unremarkable without any area of stenosis or vasospasm vasospasm /vaso·spasm/ (va´zo-) (vas´o-spazm) angiospasm; spasm of blood vessels, causing vasoconstriction.vasospas´tic
n. (Figure 2).
Posterior reversible encephalopathy syndrome Posterior reversible encephalopathy syndrome (PRES) is a syndrome characterised by headache, confusion, seizures and visual loss associated with imaging findings of bilateral cortical and subcortical brain edema.
Reversible posterior leukoencephalopathy syndrome is a clinicoradiologic entity characterized by headaches, altered mental status, seizures, and visual loss and is associated with white matter vasogenic edema predominantly affecting the posterior occipital and parietal lobes of the brain. (1) There has been some controversy about what the proper term should be for this entity because MRI has shown that lesions can occur in both gray and white matter. Therefore, a new name, posterior reversible encephalopathy syndrome (PRES), has been coined. (2) Most cases of PRES occur with hypertension or immunosuppression, but it can occur with many diverse clinical entities. (1,3) Since PRES is often unsuspected by clinicians, recognition of the characteristic imaging findings by radiologists is key to diagnosing this syndrome and should prevent deleterious work-ups or therapies.
The pathophysiology of PRES is under debate, but it is related to disordered cerebral autoregulation. Two pathophysiologic mechanisms have been proposed regarding cerebral autoregulation--cerebral vasospasm, which results in cytotoxic edema, (4) and vasodilatation vasodilatation /vaso·di·la·ta·tion/ (-di?lah-ta´shun) vasodilation.
a state of increased caliber of blood vessels. , which results in vasogenic edema. (5) The latter is more favored by most experimental and clinical data. (6,7) The pathophysiology of PRES also implicates endothelial dysfunction, especially in cases without severe hypertension, such as pre-eclampsia or cytotoxic therapies. (1)
The most characteristic imaging pattern in PRES is the presence of edema involving the white matter of the posterior portions of both cerebral hemispheres, especially the parietooccipital regions, in a relatively symmetric pattern that spares the calcarine and paramedian parts of the occipital lobes. (1) However, other structures (such as the brain stem, cerebellum, and frontal and temporal lobes) may also be involved, and although the abnormality primarily affects the subcortical white matter, the cortex and the basal ganglia may also be involved. (8) Although they are rare, gyriform signal enhancement or parenchymal hemorrhage can occur in complicated cases. (9) Recently, studies with diffusion-weighted sequences (6) and diffusion-tensor sequences (7) have shown increased apparent diffusion coefficients (ADCs) in the involved regions accompanied by anisotropy loss, which suggests reversible vasogenic edema as an underlying pathophysiology. Therefore, early diagnosis and treatment is essential for the patients' prognosis.
Posterior reversible leukoencephalopathy syndrome is a clinicoradiologic entity associated with hypertension, immunosuppression, or many diverse clinical entities. Since PRES is often unsuspected by clinicians, recognition of the characteristic imaging findings by radiologists is key to diagnosing this syndrome and should prevent deleterious work-ups or therapies.
(1.) Hinchey J, Chaves C, Appignani B, et al. A reversible posterior leukoencephalopathy syndrome. N Engl J Med. 1996;334:494-500.
(2.) Casey SO, Sampaio RC, Michel E, et al. Posterior reversible encephalopathy syndrome: Utility of fluid-attenuated inversion recovery MR imaging in the detection of cortical and subcortical lesions. AJNR Am J Neuroradiol. 2000;21:1199-1206.
(3.) Port JD, Beauchamp NJ Jr. Reversible intracerebral in·tra·cer·e·bral
Existing within the cerebrum. pathologic entities mediated by vascular autoregulatory dysfunction. Radio-Graphics. 1998;18:353-367.
(4.) Lewis LK, Hinshaw DB Jr, Will AD, et al. CT and angiographic correlation of severe neurological disease in toxemia of pregnancy toxemia of pregnancy
See preeclampsia. . Neuroradiology. 1988;30:59-64.
(5.) Strandgaard S, Paulson OB. Cerebral autoregulation. Stroke. 1984;15:413-416.
(6.) Schwartz RB, Mulkern RV, Gudbjartsson H, Jolesz F. Diffusion-weighted MR imaging in hypertensive encephalopathy: Clues to pathogenesis. Am J Neuroradiol. 1998;19:859-862.
(7.) Mukherjee P, McKinstry RC. Reversible posterior leukoencephalopathy syndrome: Evaluation with diffusion-tensor MR imaging. Radiology. 2001;219:756-765.
(8.) Lamy C, Oppenheim C, Meder JF, Mas JL. Neuroimaging in posterior reversible encephalopathy syndrome. J Neuroimaging. 2004; 14:89-96.
(9.) Schwartz RB, Jones KM, Kalina P, et al. Hypertensive encephalopathy: Findings on CT, MR imaging and SPECT imaging in 14 cases. AJR Am J Roentgenol. 1992;159:379-383.
Hyo-Jeong Lee, MD
Prepared by Hyo-Jeong Lee, MD, St. Vincent's Medical Center, Bridgeport, CT.