RIKEN Research Center for Allergy and Immunology Discovers Mechanism for Regulating Immune Response.Tokyo, Japan, Mar 24, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - RIKEN RIKEN Rikagaku Kenkyusho (Institute of Physical and Chemical Research, Japan) announced on March 22 that its Research Center for Allergy and Immunology has discovered a mechanism for regulating immune response immune response n. An integrated bodily response to an antigen, especially one mediated by lymphocytes and involving recognition of antigens by specific antibodies or previously sensitized lymphocytes. . The center has discovered that B cell scaffold protein with ankyrin repeats (BANK), a kind of adapter molecule, inhibits the immune response of the B cell. Specifically, the center has confirmed that BANK helps increase the production of IgM antibodies, suppressing the activity of the B cell and inhibits the excessive immune response. Further, the center has revealed that BANK regulates the B cell activity by the intermediary of CD40, a kind of intercellular adhesion molecule Intercellular adhesion molecules are members a family of cell adhesion molecules. They include the following:
The center expects that these findings will shed light on the research of various infections, immune deficiency immune deficiency n. See immunodeficiency. disease, and autoimmune disease. Details of the research are published in the March 21 issue of US scientific magazine Immunity. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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