RIKEN Finds Reveromycin A Effective in Treating Osteoporosis.Tokyo, Japan, Mar 8, 2006 - (JCN) - RIKEN announced on March 7 its discovery that reveromycin A, a secondary metabolite of actinomycete actinomycete Any of a group of generally low-oxygen–utilizing bacteria identified by a branching growth pattern that results in large threadlike structures. The filaments may break apart to form rods or spheroidal shapes. Some actinomycetes can form spores. , plays a role in treating osteoporosis. RIKEN and its research partners - Chubu University, Nihon Pharmaceutical University, the Tokyo Institute of Technology Tokyo Institute of Technology (東京工業大学 and Northwestern University - elucidated that reveromycin A, a secondary metabolite of Streptomyces Streptomyces (strĕp'təmī`sēz), bacterial genus of the order Actinomycetales, members of which resemble fungi in their branching filamentous structure. Various species produce such antibiotics as streptomycin and various tetracyclines. sp. SN-593, a kind of soil actinomycete, can induce the apoptosis of osteoclast osteoclast /os·teo·clast/ (os´te-o-klast?) 1. a large multinuclear cell associated with absorption and removal of bone. 2. an instrument used for osteoclasis. cells. Accordingly, they concluded that the metabolite helps suppress the progress of osteoporosis. In a separate study, they also confirmed that reveromycin A helps inhibit bone destruction in mice, reducing the loss of bone mass by 60%. RIKEN and its partners consider reveromycin A to be a promising substance, with fewer side effects and stronger effects than current treatments. Details of the research will be soon published in an online version of Proceedings of the National Academy of Sciences of the United States of America UNITED STATES OF AMERICA. The name of this country. The United States, now thirty-one in number, are Alabama, Arkansas, Connecticut, Delaware, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Mississippi, Missouri, New Hampshire, (PNAS). Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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