RIKEN Elucidates Reaction Mechanism of Indoleamine 2,3-Dioxygenase.Tokyo, Japan, Feb 16, 2006 - (JCN) - RIKEN has elucidated a reaction mechanism of indoleamine in·dole·am·ine or in·dol·am·ine n. Any of various indole derivatives, such as serotonin, containing a primary, secondary, or tertiary amine group. 2, 3-dioxygenase. Discovered by Japanese scientist Osamu Hayaishi in 1956, indoleamine 2, 3-dioxygenase is a kind of oxygenase oxygenase /ox·y·gen·ase/ (-jen-as) any oxidoreductase that catalyzes the incorporation of both atoms of molecular oxygen into a single substrate. ox·y·gen·ase n. . In the human body, indoleamine 2,3-dioxygenase degrades tryptophan tryptophan (trĭp`təfăn), organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer appears in mammalian protein. and oxygen molecules and converts them into various substances such as vitamin B. In its recent research, RIKEN analyzed the structure of indoleamine 2, 3-dioxygenase and elucidated that the oxygenase has a structure resembling a cow head. Further, tryptophan reacts directly with oxygen on a concave surface of the oxygenase structure. RIKEN expects that these findings will contribute to research on various diseases including cancer, age-related cataract, cancer and virus infection, in which the controlling of enzyme activities plays a key role. Details of the research will be published in a February 15 online version of Proceedings of the National Academy of Sciences The Proceedings of the National Academy of Sciences of the United States of America, usually referred to as PNAS, is the official journal of the United States National Academy of Sciences. of the United States of America UNITED STATES OF AMERICA. The name of this country. The United States, now thirty-one in number, are Alabama, Arkansas, Connecticut, Delaware, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Louisiana, Maine, Maryland, Massachusetts, Michigan, Mississippi, Missouri, New Hampshire, (PNAS), under the title of "Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O2 incorporation by a heme-containing dioxygenase." Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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