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RHEO CLINIC and Bausch & Lomb Launch Joint Cross-Canada AMD Patient Education Program.


Business Editors/Health/Medical Writers

TORONTO--(BUSINESS WIRE)--Nov. 10, 2003

Age-related Macular Degeneration Age-related macular degeneration (ARMD)
Degeneration of the macula (the central part of the retina where the rods and cones are most dense) that leads to loss of central vision in people over 60.
 ("AMD (Advanced Micro Devices, Inc., Sunnyvale, CA, www.amd.com) A major manufacturer of semiconductor devices including x86-compatible CPUs, embedded processors, flash memories, programmable logic devices and networking chips. ") is the leading cause of vision loss in Canadians over the age of 50. AMD is classified as either 'dry' or 'wet'. Most patients with AMD have the dry form of the disease, which causes a gradual, progressive deterioration of the macular macular adjective Related to 1. A macule 2. The macula  tissues and results in difficulty with everyday tasks such as reading, driving and visualizing colors. A much smaller number of patients progress to wet AMD where new blood vessels grow into the macular tissues of the eye and subsequently leak fluid or bleed.

There is no cure for either form of AMD. However, current advancements in treatment and research may be able to slow the normal progression of vision loss experienced with the disease. RHEO CLINIC, a wholly owned subsidiary Wholly Owned Subsidiary

A subsidiary whose parent company owns 100% of its common stock.

Notes:
In other words, the parent company owns the company outright and there are no minority owners.
 of TLC TLC total lung capacity; thin-layer chromatography.

TLC
abbr.
1. thin-layer chromatography

2.
 Vision Corporation (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
:TLCV; TSX:TLC), and Bausch & Lomb (NYSE NYSE

See: New York Stock Exchange
:BOL) are now launching a joint cross-country program to educate Canadian AMD patients and their families about these new treatment options.

Rheopheresis(R) blood filtration ("RHEO") was developed through clinical research conducted for the past ten years in Japan This is a list of years in Japan. See also the timeline of Japanese history. For only articles about years in Japan that have been written, see . Twenty-first century
2009 - 2008 - 2007 - 2006 - 2005 - 2004 - 2003 - 2002 - 2001
Twentieth century
, Western Europe and the United States. The RHEO procedure is performed using the patented Rheofilter(R) System which is designed to remove excess levels of substances known to thicken the blood, decrease blood flow and cause damage to capillary vessels. These compounds include LDL LDL - ["LDL: A Logic-Based Data-Language", S. Tsur et al, Proc VLDB 1986, Kyoto Japan, Aug 1986, pp.33-41].  ("bad") cholesterol, fibrinogen Fibrinogen

The major clot-forming substrate in the blood plasma of vertebrates. Though fibrinogen represents a small fraction of plasma proteins (normal human plasma has a fibrinogen content of 2–4 mg/ml of a total of 70 mg protein/ml), its conversion
, alpha-2-macroglobulin and other defined substances believed to be associated risk factors for macular degeneration. Clinical studies suggest that the blood filtered with RHEO is able to flow more easily through the tiny capillaries in the eye. Researchers believe that the improved microcirculation microcirculation /mi·cro·cir·cu·la·tion/ (-sir?ku-la´shun) the flow of blood through the fine vessels (arterioles, capillaries, and venules).microcirculato´ry

mi·cro·cir·cu·la·tion
n.
 more effectively supplies the macular cells with oxygen and nutrients. Clinical evidence has shown that certain high-risk AMD patients suffering from the dry form of the disease demonstrated visual improvement following rheopheresis.(1)

"Interim results from the largest apheresis apheresis (əfĕr`əsĭs), or hemapheresis (hē'məfĕr`əsĭs), any procedure in which blood is drawn from a donor or patient and a component (platelets, plasma, or white blood  trial to date, known as the MIRA-1(2) (Multi-Center Investigation of Rheopheresis for AMD), demonstrated statistically significant effects of Rheopheresis on preserving and in some cases improving visual function of dry AMD patients when compared to placebo. This is exciting data in managing the disease in combination with high dose anti-oxidant supplement therapy," commented David Wong, MD, a leading Canadian authority on AMD.

A recent ten-year clinical study conducted by the U.S. National Eye Institute found that vitamins and minerals may have a key role to play in the treatment of AMD. The Age-Related Eye Disease Study The Age-Related Eye Disease Study was a clinical trial sponsored by the National Eye Institute, one of the National Institutes of Health in the United States. The study was designed to
 (AREDS AREDS Age-Related Eye Disease Study ) found that supplementation with vitamins C and E, beta-carotene and zinc reduced certain patients' risk of progression to advanced AMD by approximately 25%(3). Bausch & Lomb Ocuvite(R) PreserVision(TM) was the one and only eye vitamin and mineral supplement tested in that NEI study.

"Only the unique high-potency antioxidant and zinc formula tested in the NEI's Age-Related Eye Disease study was clinically proven to slow the progression of AMD and its associated vision loss among patients with more advanced forms of the disease," said Michael J. Cooney, M.D., director, Duke University Center for Macular Degeneration.

Patient education materials have been created jointly by RHEO Clinic and Bausch & Lomb and will be distributed across Canada via doctors offices, retailer point-of purchase displays, sample vitamin product mailings and community seminars.

Information on AMD and rheopheresis is available at www.rheo.com or by calling toll free 1-877-AMD-EYES. Information on AMD and the Ocuvite PreserVision eye vitamin is available at www.bausch.com or by calling toll free 1-888-459-5000.

About Bausch & Lomb

Bausch & Lomb is the eye health company, dedicated to perfecting vision and enhancing life for consumers around the world. Its core businesses include soft and rigid gas permeable contact lenses and lens care products, and ophthalmic surgical and pharmaceutical products. The Bausch & Lomb name is one of the best known and most respected healthcare brands in the world. Celebrating its 150th anniversary in 2003, the Company is headquartered in Rochester, New York This article is about the city of Rochester in Monroe County. For the town in Ulster County, see Rochester, Ulster County, New York.
Rochester, once known as The Flour City, and more recently as The Flower City or
. Bausch & Lomb's 2002 revenues were $1.8 billion; it employs approximately 11,500 people worldwide and its products are available in more than 100 countries. More information about the company can be found on the Bausch & Lomb Web site at www.bausch.com.

About TLCVision

TLC Vision Corporation is North America's premier eye care services company. TLCVision enjoys a number of valuable assets including an affiliated network of more than 12,500 optometrists and 1,000 ophthalmic surgeons, access to some of the newest clinical technologies, proven patient education and marketing programs, state-of-the art information systems, a strong operations management culture and a number of well established corporate brands. More information about the company can be found on the TLCVision web site at www.tlcv.com.

(1) Transactions of the American Ophthalmological Society, 2002; 100: 85-108

(2) MIRA-1 is being conducted by Vascular Sciences Corporation

(3) Archives of Ophthalmology This article is about the journal published by the American Medical Association. For other journals and uses, see Ophthalmology (disambiguation).

The Archives of Ophthalmology
, October 2001

Forward Looking Statements

This press release contains certain forward-looking statements within the meaning of Section 27A of the U.S. Securities Act of 1933 and Section 21E of the U.S. Securities Exchange Act of 1934, which statements can be identified by the use of forward looking terminology, such as "may", "will", "expect", "intend", "anticipate", "estimate", "predict", "plans" or "continue" or the negative thereof or other variations thereon or comparable terminology referring to future events or results. The Company's actual results could differ materially from those anticipated in these forward-looking statements as a result of numerous factors, including the timing of expenditures, effects of competition, changes to pricing, acquisitions and expansion opportunities, any of which could cause actual results to vary materially from current results or TLCVision's anticipated future results. See the Company's reports filed with the Canadian Securities Regulators and the U.S. Securities and Exchange Commission from time to time for cautionary statements identifying important factors with respect to such forward looking statements, including certain risks and uncertainties, that could cause actual results to differ materially from results referred to in forward looking statements. TLCVision assumes no obligation to update the information contained in this press release.
COPYRIGHT 2003 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2003, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Geographic Code:4EUIR
Date:Nov 10, 2003
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