Quantum Dot Corporation Publishes First Multiplexed Genotyping Analysis Using Quantum Dot-Encoded Beads.Business Editors/Health/Medical Writers BIOWIRE2K HAYWARD, Calif.--(BUSINESS WIRE)--April 29, 2003 Quantum Dot (physics) quantum dot - (Or "single-electron transistor") A location capable of containing a single electrical charge; i.e., a single electron of Coulomb charge. Physically, quantum dots are nanometer-size semiconductor structures in which the presence or absence of a quantum Corporation (QDC QDC Quality, Delivery, Cost QDC Quiet-Day-Curve QDC Qatar Distribution Company QDC Quantum Data Compression QDC Qatar Data Center QDC Quadratic Double Circulant (code) QDC Quantized Dc QDC Quick Direct Connect ) announced that on April 24, 2003, Nucleic Acids Research Nucleic Acids Research or NAR is a peer reviewed scientific journal published by Oxford University Press. NAR publishes research on Nucleic Acids, such as DNA and RNA, and related work. Some of its content is available under and open access license. published the on-line version of "Multiplexed SNP SNP Scottish National Party Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily genotyping using the Qbead(TM) system: a quantum-dot encoded microsphere-based assay" co-authored by investigators at QDC and GlaxoSmithKline. The publication describes a highly accurate and sensitive method for multiplexed SNP genotyping using the Qbead(TM) encoded polymer bead system. The authors demonstrated the actual use of the Qbead(TM) system for SNP genotyping of the cytochrome cytochrome (sī`təkrōm'), protein containing heme (see coenzyme) that participates in the phase of biochemical respiration called oxidative phosphorylation. P450 family of genes. Links to the abstract and full-text versions of this publication can be found in the QDC website www.qdots.com. "We chose the cytochrome P450 gene family because of its relevance to modern drug discovery. It is generally accepted to be one of the most difficult gene families to multiplex because of the significant degree of homology homology (hōmŏl`əjē), in biology, the correspondence between structures of different species that is attributable to their evolutionary descent from a common ancestor. among the members," said Mike Sha, Ph.D., one of the QDC co-authors. "Our ability to assay for SNPs in this family using the Qbead(TM) system attests to the accuracy, sensitivity and flexibility of our technology. We only needed 1 nanogram nanogram /nano·gram/ (ng) (nan?o-gram) one billionth (10-9) of a gram. nan·o·gram n. Abbr. ng One billionth (10-9) of a gram. of genomic DNA to analyze 10 SNPs simultaneously using multiplexed PCR PCR polymerase chain reaction. PCR abbr. polymerase chain reaction Polymerase chain reaction (PCR) amplification. In fact, it only took 6 picogram picogram /pi·co·gram/ (pg) (pi´ko-gram) one-trillionth (10-12) of a gram. pi·co·gram n. Abbr. pg One-trillionth (10-12) of a gram. genomic DNA for each SNP." "This is a significant advance for the use of the Qbead(TM) system to analyze single nucleotide polymorphisms in human populations," commented Andy Watson, Vice President of Business Development at QDC. "Although other investigators have published methods of preparing quantum dot-encoded microspheres, this is the first practical application of the QDC technology to discern human genetic variations fundamental to human genetic research and pharmacogenetics Pharmacogenetics Definition Pharmacogenetics is the study of how the actions of and reactions to drugs vary with the patient's genes. Description . We will soon be launching our first products using multiplexed Qdot(TM) nanocrystal-encoded beads. We are also actively seeking marketing and assay partners to further develop and commercialize this revolutionary system." Quantum Dot Corporation is an exclusive licensee for the underlying quantum dot and encoded bead technologies from the pioneering innovators at the University of California/Lawrence Berkeley National Labs (Berkeley Labs) and M.I.T. "The inventors of quantum dot-encoded polymer beads used in the published work are at Berkeley Labs and M.I.T," emphasized Ken Barovsky, Ph.D., Vice President and Intellectual Property Counsel at QDC. "Their early U.S. patents, e.g., 6,207,392, and pending applications broadly disclose and claim encoded bead compositions, methods of preparing encoded beads, and analyte-detection assays using the Qbead(TM) system. The virtually limitless number of codes can be based on the emission wavelength of the quantum dots, i.e., two or more quantum dots that emit at different wavelengths, and/or the intensity of the emission of the signals. It is truly exciting to see this technology applied to solve problems in genetic research." Quantum Dot Corporation was founded in 1998 and is located in Hayward, CA. The company and its advisors are the world's leading experts in Qdot(TM) semiconductor nanocrystal technology and its applications. Additional information on the company and the Qdot(TM) technology can be found at www.qdots.com. For further information, please contact Carol Lou at 510-887-8775 x4102 or cclou@qdots.com. Quantum Dot Corporation Illuminating the path to scientific discovery(TM) |
|
||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion