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Protein level may help predict osteoarthritis severity.

Byline: ANI

Washington, July 31 (ANI): Scientists from University of Erlangen-Nuremberg in Erlangen, Germany have revealed that measuring the level of vascular cell adhesion molecule Cell Adhesion Molecules (CAMs) are proteins located on the cell surface involved with the binding with other cells or with the extracellular matrix (ECM) in the process called cell adhesion.  1 (VCAM-1) can help predict the severity of osteoarthritis osteoarthritis
 or osteoarthrosis or degenerative joint disease

Most common joint disorder, afflicting over 80% of those who reach age 70. It does not involve excessive inflammation and may have no symptoms, especially at first.
.

It was found to be a strong predictor of hip and knee joint replacement due to severe OA.

During the study, lead researcher Georg Schett of the University of Erlangen-Nuremberg in Erlangen, Germany looked at 912 healthy individuals in Bruneck, Italy, 60 of whom underwent hip or knee replacement surgery due to severe OA

Their blood samples were analyzed for VCAM-1, a sialoglycoprotein (a combination sugar and protein) expressed on cells in the cartilage and connective connective - An operator used in logic to combine two logical formulas. See first order logic.  tissue.

The results showed that VCAM-1 levels were substantially elevated in the 60 individuals who underwent joint replacement, with the highest baseline levels seen in those who underwent bilateral joint replacement. The level of VCAM-1 emerged as a significant predictor of the risk of joint replacement due to severe OA, equaling or even surpassing the effects of age," the authors state.

They revealed that inclusion of VCAM-1 levels in risk prediction models This article outlines the various propagation models currently used by the wireless industry for signal transmission at both 900 MHz and 1800 MHz. We start with the foundation of free-space transmission, followed by Picquenard’s multiple knife edge diffraction model.  resulted in a more accurate classification of individuals.

The authors suggest that increased VCAM-1 levels can mirror active cartilage damage or an inflammatory component in OA.

"Further clarification of the mechanism underlying the association between VCAM-1 level and OA may well contribute to a better understanding of disease etiology," the authors added.

They said that improved prediction of severe OA would help identify patients for treatment interventions such as aerobic exercise aerobic exercise,
n sustained repetitive physical activity, such as walking, dancing, cycling, and swimming, that elevates the heart rate and increases oxygen consumption resulting in improved functioning of cardio-vascular and respiratory systems.
, strength training and weight loss and might also help tailor therapeutic measures.

The study is published in Arthritis and Rheumatism rheumatism (r`mətĭzəm), general term for a number of disorders that cause inflammation and pain in muscles, bones, joints, or nerves. . (ANI)

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Publication:Asian News International
Date:Jul 31, 2009
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