Prostate Tumor Angiogenesis Successfully Targeted by Radiopharmaceutical Designed for Diagnosis and Treatment.PHILADELPHIA -- Researchers From University of Maryland University of Maryland can refer to:
A novel polymer-peptide conjugate conjugate /con·ju·gate/ (kon´jdbobr-gat) 1. paired, or equally coupled; working in unison. 2. a conjugate diameter of the pelvic inlet; used alone usually to denote the true conjugate diameter; see developed at the University of Maryland has been shown to target prostate cancer tumor vessels. The composition uses Molecular Insight Pharmaceuticals' proprietary SAAC SAAC Student-Athlete Advisory Committee SAAC Shelby American Automobile Club SAAC Student Athletic Advisory Committee SAAC Specialty Advertising Association of California (Canoga Park, CA) SAAC Students Against Animal Cruelty (TM) technology to carry diagnostic or therapeutic radionuclides with matching distribution. This advance may accelerate development of both molecular imaging pharmaceuticals and targeted cancer therapies. These results were presented today at the Society of Nuclear Medicine's annual meeting by researchers from the Company and the University of Maryland School of Medicine. "SAAC(TM) technology provides a highly 'stable' platform for interchanging imaging and therapeutic radionuclides. This murine study demonstrates that we can attach technetium technetium (tĕknē`shēəm) [Gr. technetos=artificial], artificially produced radioactive chemical element; symbol Tc; at. no. 43; mass no. of most stable isotope 98; m.p. 2,200°C;; b.p. 4,877°C;; sp. gr. 11. for cancer diagnosis and rhenium rhenium (rē`nēəm), metallic chemical element; symbol Re; at. no. 75; at. wt. 186.207; m.p. about 3,180°C;; b.p. about 5,625°C;; sp. gr. 21.02 at 20°C;; valence −1, +2, +3, +4, +5, +6, or +7. for therapy with similar effectiveness," said John Babich, Ph.D., President and Chief Scientific Officer of Molecular Insight Pharmaceuticals. "In addition, the increased radiochemical stability of SAAC(TM) has the potential to provide better cancer detection and enhance delivery of therapeutic radionuclides." Data Presented on Angiogenesis Targeting The study examined the biodistribution of labeled HPMA HPMA Hardwood Plywood Manufacturers Association HPMA Hawaii Psychiatric Medical Association HPMA High Performance Memory Array copolymers carrying angiogenesis targeting peptides (RGD RGD Rijksgebouwendienst RGD Rat Genome Database RGD Registered Graphic Designer (Canada) RGD Arginine-Glycine-Aspartic Acid RGD Rapid Gas Decompression RGD Reacting Gas Dynamics RGD Range Gate Deception RGD Returned Goods Damaged 4C). To enable radiolabeling radiolabeling incorporation of a radioactive element into a compound in order to investigate its metabolism, fate and utilization. with either technetium-99m or rhenium-188, the constructs incorporated SAAC(TM) technology. SCID SCID severe combined immunodeficiency (disease); see under immunodeficiency. SCID abbr. severe combined immunodeficiency SCID severe combined immunodeficiency disease. mice with xenografts of human prostate carcinoma (DU-145) were injected with either the technetium-99m or the rhenium-188 labeled peptide constructs. The study showed matching radioactivity biodistributions and similar high levels of tumor uptake. The results suggest that both technetium-99m and rhenium-188 labeled SAAC(TM) peptide constructs have potential for molecular imaging and targeted radiotherapy. "We are excited about the potential of Molecular Insight's technology to improve molecular imaging and enable successful radiotherapy applications," said Bruce Line, M.D., Professor of Radiology and Director Division of Nuclear Medicine, Department of Radiology University of Maryland Medical System. "Noninvasive detection of prostate and other cancers at the earliest stages is an important medical need. Combining SAAC(TM) with our novel polymer-peptide constructs has enabled us to look forward to clinical applications in both diagnosis and treatment." Potential Applications of SAAC(TM) According to Dr. Babich, SAAC(TM) technology has also been used to develop novel peptide libraries to evaluate candidates useful in molecular imaging and radiotherapy applications. The company presented data on the design and synthesis of SAAC(TM) at the 2003 Society of Nuclear Medicine meeting and demonstrated its potential to image infection. Molecular Insight Pharmaceuticals is scheduled to present six studies at the 2004 SNM SNM Society of Nuclear Medicine SNM Show No Mercy (gaming clan) SNM Special Nuclear Material SNM Somali National Movement SNM San Marcos (Guatemala, territorial division) SNM Service Member meeting related to SAAC(TM) and its potential in drug development as well as labeling insulin, glucose and the vitamin, biotin biotin: see vitamin; coenzyme. biotin Organic compound, part of the vitamin B complex, essential for growth and well-being in animals and some microorganisms. for use in oncology.
Researchers: Amitava Mitra, Justin Mulholland, Anjan Nan, Hamid
Ghandehari, Edwina McNeill and Bruce Line from the University of
Maryland and John Babich of Molecular Insight Pharmaceuticals.
Location: Philadelphia Convention Center
Exhibit Hall C
Time: Tuesday, June 22, 2004
4:30-5:15 p.m., EDT
About Molecular Insight Pharmaceuticals, Inc. Molecular Insight Pharmaceuticals, Inc. is a privately held biopharmaceutical company focused on leveraging its proprietary technology platforms in molecular medicine to develop innovative pharmaceuticals to diagnose and treat disease. These products are designed to improve the management of disease by targeting, visualizing, treating and monitoring disease at the molecular level. The Company, based in Cambridge, Massachusetts, has established a strong pipeline of molecular imaging candidates focused on the large and growing markets in cardiology, oncology and neurology. Molecular Insight is also applying its platform technologies to develop targeted radiotherapeutics for the treatment of cancer. www.molecularinsight.com Image of molecule available from Molecular Insight Pharmaceuticals, Inc. |
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