Prolinx Announces Release of Two New Products for the Proteomics Market.Business Editors & Health/Medical Writers BIOWIRE2K BOTHELL, Wash.--(BW HealthWire)--Jan. 17, 2002 Prolinx(R), Inc., announced today the release of two new products for protein detection, Versalinx(TM) Rapid Protein-Enzyme Conjugation conjugation, in genetics conjugation, in genetics: see recombination. conjugation, in grammar conjugation: see inflection. Kits, HRP and AP. These products expand upon the company's proteomics product portfolio and incorporate Prolinx' proprietary Versalinx affinity technology that is widely used for immobilization Immobilization Definition Immobilization refers to the process of holding a joint or bone in place with a splint, cast, or brace. This is done to prevent an injured area from moving while it heals. of macromolecules Macromolecules A large molecule composed of thousands of atoms. Mentioned in: Gene Therapy macromolecules in genomics, proteomics and bioresearch assays. Proteomics, or the comprehensive and systematic analysis of proteins in an organism, presents many bioanalytical challenges not encountered when studying genomes which are composed of DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. , a nucleic acid. This new epoch in bioresearch requires novel technologies that allow for complete characterization of proteins and their modes of action in controlling biological functions, information that is fundamental for improving human health and eliminating disease. Versalinx Chemical Affinity Technology utilizes the specific interaction between two small, synthetic molecules -- rather than biomolecules This page aims to list articles on Wikipedia that describe particular biomolecules or types of biomolecules. This list is not necessarily complete or up to date - if you see an article that should be here but isn't (or one that shouldn't be here but is), please update the page -- as affinity binding components. These small molecules, P(D)BA and SHA SHA - Secure Hash Algorithm (phenyl phenyl (fĕn`əl), C6H5, organic free radical or alkyl group derived from benzene by removing one hydrogen atom. (di)boronic acid and salicylhydroxamic acid, respectively), interact to form a molecular complex under a wide range of conditions and are used to modify nucleic acids, proteins, and other macromolecules for use in analytical and preparative pre·par·a·tive adj. Serving or tending to prepare or make ready; preliminary. n. Something that prepares for or acts as a preliminary to something following. assays. Unique to Versalinx Tools is the ability to optimize parameters to afford controlled complex avidity avidity /avid·i·ty/ (ah-vid´i-te) 1. the strength of an acid or base. 2. in immunology, an imprecise measure of the strength of antigen-antibody binding based on the rate at which the complex is formed. Cf. , release, and retention of biological activity. Prolinx offers a wide range of analytical and sample prep reagents -- in addition to protein chips or microarrays -- based upon this chemistry. The new detection products use the Versalinx complex to quickly attach an enzyme molecule (horseradish peroxidase or alkaline phosphatase) to any protein probe. The enzyme is then used to change a substrate to a detectable signal such as a visible color, light or fluorescence, enabling detection of probe-target interactions in solid phase assays. This product allows researchers to label any protein detection probe, especially proprietary probes that are not commercially available as detection reagents, without significant loss of biological activity. "Developing effective detection assays is one of the many challenges scientific investigators face in the field of proteomics," stated Jim Mahoney, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board. . "Even when detection reagents are available, current technology is often laborious and yields poor results. These new Versalinx tools greatly simplify the creation of assays and will accelerate discoveries in biological research." Prolinx, founded in 1995, is a privately held biotechnology company located north of Seattle, Wash., USA. The company develops, manufactures, and markets tools, applications, and systems that advance developments in bioresearch, biotechnology and drug discovery. The company has commercialized a number of proprietary technologies including: Versalinx(TM) Chemical Affinity Tools, a synthetic chemical affinity technology targeted at the proteomics and genomics markets; Versalinx Protein Microarray Technology, a novel open platform array system specifically designed to enable developments in the emerging protein chip market; and RapXtract DNA Purification Technology, for extraction of contaminating dye labels from genomics samples. The company is also developing instruments for label-free molecular interaction analysis based upon advances in surface plasmon resonance The excitation of surface plasmons by light is denoted as a surface plasmon resonance (SPR) for planar surfaces or localized surface plasmon resonance (LSPR) for nanometer-sized metallic structures. technology. The first instrument, the Octave(TM) Molecular Interaction Analysis System will be released in early 2002. Information about Prolinx is available at www.prolinxinc.com or by phoning 425/487-3401. Prolinx is a registered trademark, and Octave, RapXtract and Versalinx are trademarks, of Prolinx, Inc. Keywords: proteomics, detection, Versalinx, affinity technology, bioconjugation, fluorescence, chemiluminescence, non-radioactive detection |
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