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Principles and methods for assessing autoimmunity associated with exposure to chemicals.


Principles and methods for assessing autoimmunity Autoimmunity

The occurrence in an organism of an immune response to one of its own tissues, that is, a response to a self constituent. Efficient discrimination between self and nonself, the basis of normal immune function, depends upon a function known as
 associated with exposure to chemicals.

World Health Organization


333 pages



Environmental health criteria series; no.236


In keeping with the title, the chapters of this report describe the mechanisms of chemical-associated autoimmune autoimmune /au·to·im·mune/ (-i-mun´) directed against the body's own tissue; see under disease and response.

 responses, chemical/physical agents and autoimmunity, and non-chemical factors in autoimmunity, as well as risk assessment. Initial sections describe intrinsic factors intrinsic factor
A relatively small mucoprotein secreted by the parietal cells of gastric glands and required for adequate absorption of vitamin B12 for production of red blood cells. Also called Castle's intrinsic factor.
 in autoimmunity, the clinical expression of human autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. In rheumatoid arthritis, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma , and epidemiology. Both animal models and human testing are described. This report was sponsored by the United Nations Environment Programme, the International Labour Organization, and the World Health Organization. There is a lengthy list of references and a glossary, but no index. The text is also available as a pdf file See PDF.  at

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Publication:SciTech Book News
Article Type:Book Review
Date:Dec 1, 2007
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