Prenatal PAH exposure causes genetic changes in newborns.Research has suggested that in utero exposure to pollutants can cause DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. damage, chromosomal changes, and increased risk of childhood cancers such as leukemia. Other studies have indicated that pediatric pediatric /pe·di·at·ric/ (pe?de-at´rik) pertaining to the health of children. pe·di·at·ric adj. Of or relating to pediatrics. leukemia is initiated prior to birth. Now NIEHS grantee An individual to whom a transfer or conveyance of property is made. In a case involving the sale of land, the buyer is commonly known as the grantee. grantee n. Frederica Perera and colleagues at Columbia University demonstrate for the first time that prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) causes chromosomal changes that have been linked to leukemia and other cancers. PAHs are a group of more than 100 different chemicals that are formed during the incomplete burning of almost any organic substance, including coal, oil, and gasoline. PAHs can cross the placenta, and many have been shown to cause cancer in animal studies. The Columbia researchers used a technique known as fluorescence in situ hybridization Fluorescence in situ hybridization (FISH) A technique for diagnosing DiGeorge syndrome before birth by analyzing cells obtained by amniocentesis with DNA probes. FISH is about 95% accurate. to identify and count the number and types of chromosomal changes that occurred in a subset of 60 African-American and Dominican newborns from the Columbia Center for Children's Environmental Health Prospective Cohort Study in New York City New York City: see New York, city. New York City City (pop., 2000: 8,008,278), southeastern New York, at the mouth of the Hudson River. The largest city in the U.S. . They measured chromosomal changes in cultured white blood cells White blood cells A group of several cell types that occur in the bloodstream and are essential for a properly functioning immune system. Mentioned in: Abscess Incision & Drainage, Bone Marrow Transplantation, Complement Deficiencies from umbilical cord blood umbilical cord blood Transplantation A source of primitive and stem cells that can be used to reconstitute BM destroyed by aplastic anemia or by RT or chemotherapy for CA, lymphoproliferative malignancies. See Bone marrow transplantation, Stem cell therapy. . The researchers assessed prenatal exposure via questionnaires administered to the babies' mothers during the third trimester of pregnancy, and by analyzing data from personal air monitors that the mothers wore during their third trimester. The researchers found that exposure to airborne PAHs was significantly associated with stable chromosomal aberrations. They also observed that African-American babies had a higher frequency of chromosomal changes than Dominican babies, suggesting the presence of either other unmeasured factors or variations in susceptibility. These findings suggest that prenatal exposures may cause the cytogenetic damage that has been related to increased cancer risk, the researchers write. This information has global importance because air pollution conditions similar to those in New York City exist in other cities in the United States and the world. Although further research is necessary to confirm these findings and to estimate the increase in cancer risk from the exposures, these results demonstrate once again the importance of protecting children from avoidable harmful exposures. |
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