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Preclinical Data on FermaVir's FV-100 Presented at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy.


NEW YORK New York, state, United States
New York, Middle Atlantic state of the United States. It is bordered by Vermont, Massachusetts, Connecticut, and the Atlantic Ocean (E), New Jersey and Pennsylvania (S), Lakes Erie and Ontario and the Canadian province of
 -- FermaVir Pharmaceuticals, Inc. (Nasdaq OTC OTC

See: Over-the-counter.


OTC

See over-the-counter market (OTC).
:BB: FMVR) and its academic collaborators from the Rega Institute for Medical Research The Rega Institute for Medical Research is a Belgian scientific establishment that is part of the Catholic University of Leuven (Leuven) in central Belgium. The Rega Iinstitute is an interfacultary biomedical research institute of the Catholic University of Leuven and consists of  and Cardiff University yesterday presented data from preclinical studies for FV-100, a highly potent, orally bioavailable bicyclic bi·cy·clic   also bi·cy·cli·cal
adj.
1. Consisting of or having two cycles.

2. Botany Composed of or arranged in two distinct whorls, as the petals of a flower.

3.
 nucleoside analogue for the treatment of herpes zoster infections (shingles), at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy (print-ISSN 0066-4804, CODEN AMACCQ; canceled ISSN 0074-9923, canceled CODEN AACHAX) is an academic journal published by the American Society for Microbiology.  (ICAAC ICAAC Interscience Conference on Antimicrobial Agents and Chemotherapy
ICAAC Iowa Community College Athletic Conference
) in Chicago. The data demonstrated favorable antiviral and pharmacokinetic properties for FV-100, including the compound's bioavailability bioavailability /bio·avail·a·bil·i·ty/ (bi?o-ah-val?ah-bil´i-te) the degree to which a drug or other substance becomes available to the target tissue after administration.

bi·o·a·vail·a·bil·i·ty
n.
 and activity against Varicella-Zoster Virus (VZV VZV Varicella-zoster virus, see there ).

"These data on FV-100 provide further evidence of the compound's antiviral activity and continue to differentiate FV-100 from compounds marketed or in development for shingles," stated Geoffrey Henson, Ph.D., chief executive officer of FermaVir. "Specifically, the compound's bioavailability and ability to rapidly inhibit VZV suggest that FV-100 has the potential to be a more potent treatment option for shingles and further reduce the symptoms associated with shingles, such as acute pain and post-herpetic neuralgia."

Dr. Graciela Andrei from the Rega Institute presented data demonstrating the bioavailability for FV-100 in a poster titled "FV-100, a Pro-Drug of CF-1743, as Potential Candidate for the Treatment of Varicella-Zoster Virus Infections." The active component of FV-100, CF-1743 required only a 2 hour exposure time on infected cells, as compared to approximately 1 and 3 days for brivudin and acyclovir acyclovir /acy·clo·vir/ (a-si´klo-ver) a synthetic purine nucleoside with selective activity against herpes simplex virus; used as the base or the sodium salt in the treatment of genital and mucocutaneous herpesvirus infections. , respectively, to completely exert their anti-VZV activity. Furthermore, confocal microscopy supported the rapid internalization Internalization

A decision by a brokerage to fill an order with the firm's own inventory of stock.

Notes:
When a brokerage receives an order they have numerous choices as to how it should be filled.
 of both FV-100 and CF-1743 into cells.

In the poster titled "Activity of CF-1743 Against Varicella-Zoster Virus in Human Primary Epithelial Cells Grown in 2D and 3D Culture Models," FermaVir scientists presented new data demonstrating the potency and selectivity of FV-100, a pro-drug of CF-1743. In a model using primary human keratinocytes Keratinocytes
Cells found in the epidermis. The keratinocytes at the outer surface of the epidermis are dead and form a tough protective layer. The cells underneath divide to replenish the supply.
 to mimic human skin, CF-1743 was found to be 10 to 400 times more potent than acyclovir and brivudin. In addition, the effect of CF-1743 on viral DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 production correlated with the inhibition of the virus as measured by virus-induced cytopathicity in this model.

About FermaVir

FermaVir Pharmaceuticals, Inc. is an emerging biotechnology company positioned for rapid growth by developing important antiviral drugs and other treatments in underserved segments of the pharmaceutical development marketplace. FermaVir licensed the technology for FV-100 from Cardiff University in 2005. The technology was a joint discovery from the laboratories of Professor Chris McGuigan from Cardiff University, Cardiff, Wales Wales, Welsh Cymru, western peninsula and political division (principality) of Great Britain (1991 pop. 2,798,200), 8,016 sq mi (20,761 sq km), west of England; politically united with England since 1536. The capital is Cardiff. , United Kingdom and Professors Erik De Clercq and Jan Balzarini of the Rega Institute, Katholieke Universiteit, Leuven, Belgium. FermaVir has a continuing collaboration with both research groups. FermaVir is also developing a series of compounds that could improve the treatment of Cytomegalovirus cytomegalovirus (sī'təmĕg'əlōvī`rəs), member of the herpesvirus family that can cause serious complications in persons with weakened immune systems.  (CMV CMV cytomegalovirus.

CMV
abbr.
1. controlled mechanical ventilation

2. cytomegalovirus


Cytomegalovirus (CMV) 
) infection, a currently incurable viral disease that can threaten eyesight as well as cause severe morbidity and mortality Morbidity and Mortality can refer to:
  • Morbidity & Mortality, a term used in medicine
  • Morbidity and Mortality Weekly Report, a medical publication
See also
  • Morbidity, a medical term
  • Mortality, a medical term
 mostly in the immunosuppressed Immunosuppressed
A state in which the immune system is suppressed by medications during the treatment of other disorders, like cancer, or following an organ transplantation.

Mentioned in: Fifth Disease
. FermaVir's Intellectual Property portfolio includes a number of patent applications and a worldwide exclusive license for potential new drug treatments of infectious diseases. On April 10, 2007, FermaVir announced that it has entered into a definitive agreement to merge with Inhibitex, Inc., which is expected to close in September 2007. For additional information about FermaVir, please visit www.fermavir.com.

Additional Information about the Merger and Where to Find It

In connection with the proposed merger, Inhibitex and FermaVir have filed relevant materials with the Securities and Exchange Commission (SEC), including a registration statement on Form S-4 that contains a prospectus and a joint proxy statement. The registration statement was declared effective by the SEC on August 10, 2007. Investors and security holders of Inhibitex and FermaVir are urged to read these materials because they contain important information about Inhibitex, FermaVir and the merger. The proxy statement, prospectus and other relevant materials (when they become available), and any other documents filed by Inhibitex and FermaVir with the SEC, may be obtained free of charge at the SEC's web site at www.sec.gov. In addition, investors and security holders may obtain free copies of the documents filed with the SEC by Inhibitex by directing a written request to: Inhibitex, 9005 Westside Parkway, Alpharetta, GA 30004, Attention: Investor Relations; and documents filed with the SEC by FermaVir by directing a written request to FermaVir, 420 Lexington Avenue, Suite 445, New York, N.Y. 10170, Attention: Investor Relations. Investors and security holders are urged to read the proxy statement, prospectus and the other relevant materials before making any voting or investment decision with respect to the merger.

Participants in the Solicitation

Inhibitex and FermaVir and their respective directors, executive officers and employees may be deemed to be participants in the solicitation of proxies from the stockholders of Inhibitex and FermaVir in connection with the proposed transaction. Information regarding the special interests of these directors and executive officers in the merger transaction is included in the proxy statement/prospectus referred to above. Additional information regarding the directors and executive officers of Inhibitex is also included in Inhibitex's Amendment No. 1 to the Annual Report on Form 10-K for year ended December 31, 2006. This document is available free of charge at the SEC's web site (www.sec.gov) and from Investor Relations at Inhibitex at the address set forth above. Additional information regarding the directors and executive officers of FermaVir is also included in FermaVir's Annual Report on Form 10-KSB for the year ended April 30, 2007. This document is available free of charge at the SEC's web site (www.sec.gov) and from Investor Relations at FermaVir at the address set forth above.

Safe Harbor Statement

Some of the statements included in this press release are forward-looking statements that involve a number of risks and uncertainties, including, but not limited to: statements regarding the proposed acquisition, future market opportunity and future financial performance. For those statements, we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. Important factors may cause our actual results to differ materially, including, but not limited to, the satisfaction of the conditions to the closing of the pending merger transaction with Inhibitex, including approvals by the stockholders of both corporations, the Board of Directors of neither FermaVir nor Inhibitex withdrawing its support for the pending merger transactions, uncertainties associated with product development, the risk that FermaVir will not obtain approval to market its products, the risk that FermaVir technology will not gain market acceptance, the risks associated with dependence upon key personnel, the need for additional financing; and other cautionary statements contained elsewhere herein and in FermaVir's Annual Report on Form 10-KSB for the year ended April 30, 2007, as filed with the Securities and Exchange Commission. Any forward-looking statements set forth in this press release speak only as of the date of this press release. We do not intend to update any of these forward-looking statements to reflect events or circumstances that occur after the date hereof.
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Article Type:Conference news
Date:Sep 19, 2007
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