Pharsight Corporation and the Duke Clinical Research Institute in Collaboration to Provide Internet Access to Clinical Database Information.

Business Editors/Medical & Health Writers

MOUNTAIN VIEW, Calif.--(BUSINESS WIRE)--March 14, 2000

Pharsight Corporation and the Duke Clinical Research Institute (DCRI) announced today a collaboration to develop database resources for use with Pharsight's Clinical Workbench(TM) Internet-based system that gives users query-analysis access to medical databases without compromising data security to patients, doctors, and health care organizations. Pharsight describes the Clinical Workbench system in a related announcement also released today.

The collaboration will initially focus on cardiovascular applications using the DCRI databases of data on chronic congestive heart failure (CHF) and acute coronary syndrome (ACS), including unstable angina and myocardial infarction. Pharsight and DCRI plan to develop additional databases for diabetes and other important therapeutic areas.

Access to valuable medical data with complete data security

Dr. Gilbert Smith, associate director of Duke University's Office of Science and Technology, said, "We are pleased to collaborate with Pharsight in the use of our databases representing a world-class resource in medical histories, disease severity, treatments, and clinical outcomes. Providing complete data security for our patients is a high priority in the Pharsight-DCRI collaboration. Not only are the data provided by DCRI anonymized (all patient identifiers removed), but Pharsight's Clinical Workbench lets users see graphical and tabular results of statistical analysis while preventing user access to individual medical records. The ability to provide valuable outcomes information without compromise to patient privacy is very important to us."

Internet technology saves time in answering complex clinical development questions

Steven Shafer, M.D. and vice president of Pharsight's Information Products group says, "With the Clinical Workbench, clinicians, investigators, and key decision makers have the ability to ask questions using DCRI databases directly from their desktop, allowing them to answer difficult clinical development questions in a day, rather than in months. They now have an on-line tool for exploring the prevalence of risk factors, the incidence of key events, the

feasibility of enrollment criteria, and the relationship between treatment, markers of response, and long term outcome."

The Duke Clinical Research Institute (DCRI) is the world leader in cardiology clinical trials and clinical drug research. DCRI combines the scientific thought leadership of Duke University Medical Center with significant clinical trials operational capabilities to perform phase II-IV clinical trials and outcomes research studies. The ACS and CHF databases represent a world-class store of medical knowledge about patients with these conditions and a state-of-the-art resource for answering drug development questions with real-life data. Information about the Duke Clinical Research Institute is available on the Worldwide Web at http://www.dcri.duke.edu/

Pharsight Corporation is the leading developer and marketer of software products and consulting services that help to significantly reduce the complexity, cost and duration of the clinical development process. The company's proprietary technology and world-class consulting expertise enable pharmaceutical and biotechnology companies to make more confident decisions in dealing with complex issues of drug development and product portfolio management, which can lead to more successful and predictable trial outcomes. Pharsight's integrated suite of computer-assisted clinical trial design, modeling, forecasting and simulation products are standards in the industry, and are used by the top pharmaceutical companies and many of the leading biotechnology companies. Pharsight Corporation is headquartered in Mountain View, California. Information about Pharsight Corporation is available on the Worldwide Web at http://www.pharsight.com.

Note to Editors: Pharsight is a registered trademark of Pharsight Corporation. All other trademarks mentioned herein are property of their respective owners.