Parkinson's, Alzheimer's, and Diabetes Are Just Some of the Diseases That Are Expected to Benefit Form Stem-Cell Research.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c31634) has announced the addition of Applications of Stem Cells stem cells, unspecialized human or animal cells that can produce mature specialized body cells and at the same time replicate themselves. Embryonic stem cells are derived from a blastocyst (the blastula typical of placental mammals; see embryo), which is very young in Drug Discovery to their offering. Business Implications --The development of stem cells for therapeutic purposes, including cell therapy and regenerative re·gen·er·a·tive adj. 1. Of, relating to, or marked by regeneration. 2. Tending to regenerate. re·gen medicine, is emerging as a major field of pharmaceutical research. Stem-cell technology is also making inroads inroads Noun, pl make inroads into to start affecting or reducing: my gambling has made great inroads into my savings inroads npl to make inroads into [+ in drug discovery. This technology offers great potential for understanding disease mechanisms and identifying targets. Pharmaceutical companies that successfully integrate stem-cell technologies will have a competitive advantage. --Stem cells have numerous applications in drug discovery. They are important for understanding differentiation pathways, for identifying factors needed to manipulate cell lineages, for improving screening assays, and for identifying disease targets. The production of stem-cell-derived human hepatocytes will have an immediate impact on toxicology toxicology, study of poisons, or toxins, from the standpoint of detection, isolation, identification, and determination of their effects on the human body. Toxicology may be considered the branch of pharmacology devoted to the study of the poisonous effects of drugs. and metabolism studies. --Dozens of stem-cell companies are competing with one another and seeking collaborations with big pharmaceutical companies. Although the technology in these companies is still primarily in the research phase, some groups have demonstrated proof-of-concept for stem-cell technologies in animal models. Those companies that ultimately control the rights to stem cells and their uses will become dominant players. Companies that conduct stem-cell-based drug discovery and product development will achieve the greatest value. --An important new approach in the stem-cell field is the creation of multidisciplinary research consortia of academic, medical, government, and industry partners. Although consortia could foster major advances, whether they will be able to translate basic research into the commercial arena is unclear. If successful, the consortia members will gain a major advantage in developing and applying stem-cell technology. Stem cells are unspecialized cells that can differentiate into numerous types of specialized cells with specific functions. Diseases and disorders that might benefit from stem-cell research Noun 1. stem-cell research - research on stem cells and their use in medicine biological research - scientific research conducted by biologists embryonic stem-cell research - biological research on stem cells derived from embryos and on their use in medicine include Parkinson's, Alzheimer's, diabetes, cancer, heart disease, spinal cord injury Spinal Cord Injury Definition Spinal cord injury is damage to the spinal cord that causes loss of sensation and motor control. Description Approximately 10,000 new spinal cord injuries (SCIs) occur each year in the United States. , and multiple sclerosis, as well as organ transplantation The transfer of organs such as the kidneys, heart, or liver from one body to another. The transplantation of human organs has become a common medical procedure. Typical organs transplanted are the kidneys, heart, liver, pancreas, cornea, skin, bones, and lungs. and wound treatment. Stem cells are also a valuable source of material in drug discovery, high-content screening High Content screening is an automated cell biology method drawing on optics, chemistry, biology and image analysis to permit rapid, highly parallel biological research and drug discovery. assays, and toxicology studies. In this Decision Resources report, we discuss the study of both undifferentiated undifferentiated /un·dif·fer·en·ti·at·ed/ (un-dif?er-en´she-at-ed) anaplastic. un·dif·fer·en·ti·at·ed adj. Having no special structure or function; primitive; embryonic. stem cells and adult stem cells Adult stem cells are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues. Also known as somatic (from Greek Σωματικóς, of the body , the use of stem-cell biology to elucidate e·lu·ci·date v. e·lu·ci·dat·ed, e·lu·ci·dat·ing, e·lu·ci·dates v.tr. To make clear or plain, especially by explanation; clarify. v.intr. To give an explanation that serves to clarify. the pathways and mechanisms involved in different diseases, ongoing research to develop methods of using stem cells to replace disease-damaged cells, stem-cell-based drug discovery platforms, the use of stem cells in drug screening and toxicology, and the outlook for stem-cell-based drug discovery. We also profile companies and consortia involved in stem-cell research and examine the legal issues surrounding the field. Topics Covered Introduction Overview of Stem Cells Legal Issues Stem-Cell Development Adult Stem-Cell Research Target Identification: Manipulating Differentiation Pathways Stem-Cell Therapy vs. Cell Protection Stem Cells in Cellular Assays for Screening Stem-Cell-Based Drug Discovery Platforms Drug Screening and Toxicology Stem-Cell-Based Consortia Outlook for Stem-Cell-Based Drug Discovery Figure 1. Embyonic Stem Cells (ESCs) Differentiate into Any Cell Type Table 1. Available Human Embryonic Stem-Cell Lines Eligible for Use with U.S. Federal Funding Table 2. Select Companies Active in the Development and Application of Stem Cells Table 3. Select Consortia and Institutes Involved in Stem-Cell Research Companies Mentioned --Aastrom Biosciences --Advanced Cell Technology --AmCyte --Arteriocyte --Athersys --BeFutur Biotechnologies --Cellartis --Cellerant Therapeutics --CNAssays --CyThera --Develogen --Epiontis For more information visit http://www.researchandmarkets.com/reports/c31634 |
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